1 research outputs found
Development of Large-Scale Routes to Potent GPR119 Receptor Agonists
Practical and scalable syntheses
were developed that were used
to prepare multikilogram batches of GSK1292263A (<b>1</b>) and
GSK2041706A (<b>15</b>), two potent G protein-coupled receptor
119 (GPR119) agonists. Both syntheses employed relatively cheap and
readily available starting materials, and both took advantage of an
S<sub>N</sub>Ar synthetic strategy