Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo

For the proper organization of the six-layered mammalian neocortex it is required that neurons migrate radially from their place of birth towards their designated destination. The molecular machinery underlying this neuronal migration is still poorly understood. The dynein-adaptor protein BICD2 is associated with a spectrum of human neurologi

Galaxy bulges and their massive black holes: a review

With references to both key and oft-forgotten pioneering works, this article starts by presenting a review into how we came to believe in the existence of massive black holes at the centres of galaxies. It then presents the historical development of the near-linear (black hole)-(host spheroid) mass relation, before explaining why this has recently been dramatically revised. Past disagreement over the slope of the (black hole)-(velocity dispersion) relation is also explained, and the discovery of sub-structure within the (black hole)-(velocity dispersion) diagram is discussed. As the search for the fundamental connection between massive black holes and their host galaxies continues, the competing array of additional black hole mass scaling relations for samples of predominantly inactive galaxies are presented.Comment: Invited (15 Feb. 2014) review article (submitted 16 Nov. 2014). 590 references, 9 figures, 25 pages in emulateApJ format. To appear in "Galactic Bulges", E. Laurikainen, R.F. Peletier, and D.A. Gadotti (eds.), Springer Publishin

Joint Observation of the Galactic Center with MAGIC and CTA-LST-1

MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes (IACTs), designed to detect very-high-energy gamma rays, and is operating in stereoscopic mode since 2009 at the Observatorio del Roque de Los Muchachos in La Palma, Spain. In 2018, the prototype IACT of the Large-Sized Telescope (LST-1) for the Cherenkov Telescope Array, a next-generation ground-based gamma-ray observatory, was inaugurated at the same site, at a distance of approximately 100 meters from the MAGIC telescopes. Using joint observations between MAGIC and LST-1, we developed a dedicated analysis pipeline and established the threefold telescope system via software, achieving the highest sensitivity in the northern hemisphere. Based on this enhanced performance, MAGIC and LST-1 have been jointly and regularly observing the Galactic Center, a region of paramount importance and complexity for IACTs. In particular, the gamma-ray emission from the dynamical center of the Milky Way is under debate. Although previous measurements suggested that a supermassive black hole Sagittarius A* plays a primary role, its radiation mechanism remains unclear, mainly due to limited angular resolution and sensitivity. The enhanced sensitivity in our novel approach is thus expected to provide new insights into the question. We here present the current status of the data analysis for the Galactic Center joint MAGIC and LST-1 observations

Understanding Gambling: Mechanisms and Predictors: Alberta Gambling Research Institute's 15th Annual Conference

The Alberta Gambling Research Institute and the University of Calgary co-sponsored the fifteenth in a series of special interest conferences in the area of gambling studies. The conference theme was "Understanding Gambling: Mechanisms and Predictors." The conference took place Thursday, April 7, Friday, April 8, & Saturday, April 9, 2016 at The Banff Centre.YesAlberta Gambling Research Institut

DeActs : genetically encoded tools for perturbing the actin cytoskeleton in single cells

The actin cytoskeleton is essential for many fundamental biological processes, but tools for directly manipulating actin dynamics are limited to cell-permeable drugs that preclude single-cell perturbations. Here we describe DeActs, genetically encoded actin-modifying polypeptides, which effectively induce actin disassembly in eukaryotic cells. We demonstrate that DeActs are universal tools for studying the actin cytoskeleton in single cells in culture, tissues, and multicellular organisms including various neurodevelopmental model systems

Multi-epoch monitoring of TXS 0506+056 with MAGIC and MWL partners

The measurement of an astrophysical flux of high-energy neutrinos by IceCube is an important step towards finding the long-sought sources of cosmic rays. Nevertheless, the long exposure neutrino sky map shows no significant indication of point sources so far. The real-time follow- up of neutrino events turned out to be the most successful approach in neutrino point-source searches. It brought, among others, the most compelling evidence for a neutrino point source: the flaring gamma-ray blazar TXS 0506+056 in coincidence with a single high-energy neutrino from IceCube (IceCube-170922A). The fast multiwavelength(MWL) follow-up of this alert was key for establishing this coincidence and constraining the subsequent theoretical modeling for this event. In the long run, accurate and contemporaneous MWL spectral measurements are essential ingredients in investigating the physical processes leading to particle acceleration and emission of radiation. A deeper understanding of those processes allows us to put constraints on the potential neutrino emission. Here we present the light curves and simultaneous spectral energy distributions from November 2017 till February 2021 of MAGIC and MWL monitoring of TXS 0506+056. The more than two-year-long rise and high state of the radio light curve of TXS 0506+056, which started near the time of the IceCube neutrino detection, seems to have ended, as indicated by a steep decrease in the first half of 2021. We also present the theoretical interpretation of our observations

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

An amendment to this paper has been published and can be accessed via a link at the top of the paper