Generation of superoxide and singlet oxygen from α-tocopherolquinone and analogues.

Three potential routes to generation of reactive oxygen species from a tocopherolquinone have been identified. The quinone of the water-soluble vitamin E analogue Trolox C (Trol-Q) is reduced by hydrated electron and isopropanol a hydroxyalkyl radical, and the resulting semiquinone reacts with molecular oxygen to form superoxide with a second order rate constant of 1.3 x 108 dm3 mol-1 s-1, illustrating the potential for redox cycling. Illumination (UV-A, 355 nm) of the quinone of 2,2,5,7,8-pentamethyl-6-hydroxychromanol (PMHC-Q) leads to a reactive short-lived (ca 10-6 s) triplet state, able to oxidise tryptophan with a second order rate constant greater than 109 dm3 mol-1 s-1. The triplet states of these quinones sensitize singlet oxygen formation with quantum yields of about 0.8. Such potentially damaging reactions of a tocopherolquinone may in part account for the recent findings that high levels of dietary vitamin E supplementation lack any beneficial effect and may lead to slightly enhanced levels of overall mortality

'Datafication': Making sense of (big) data in a complex world

This is a pre-print of an article published in European Journal of Information Systems. The definitive publisher-authenticated version is available at the link below. Copyright @ 2013 Operational Research Society Ltd.No abstract available (Editorial

No Detectable Fertility Benefit from a Single Additional Mating in Wild Stalk-Eyed Flies

Background: Multiple mating by female insects is widespread, and the explanation(s) for repeated mating by females has been the subject of much discussion. Females may profit from mating multiply through direct material benefits that increase their own reproductive output, or indirect genetic benefits that increase offspring fitness. One particular direct benefit that has attracted significant attention is that of fertility assurance, as females often need to mate multiply to achieve high fertility. This hypothesis has never been tested in a wild insect population.Methodology/Principal Findings: Female Malaysian stalk-eyed flies (Teleopsis dalmanni) mate repeatedly during their lifetime, and have been shown to be sperm limited under both laboratory and field conditions. Here we ask whether receiving an additional mating alleviates sperm limitation in wild females. In our experiment one group of females received a single additional mating, while a control group received an interrupted, and therefore unsuccessful, mating. Females that received an additional mating did not lay more fertilised eggs in total, nor did they lay proportionately more fertilised eggs. Female fertility declined significantly through time, demonstrating that females were sperm limited. However, receipt of an additional mating did not significantly alter the rate of this decline.Conclusions/Significance: Our data suggest that the fertility consequences of a single additional mating were small. We discuss this effect (or lack thereof), and suggest that it is likely to be attributed to small ejaculate size, a high proportion of failed copulations, and the presence of X-linked meiotic drive in this species

A Workflow for Probabilistic Calibration of Models of Left Atrial Electrophysiology

Atrial fibrillation is an increasingly common condition. Computational models that describe left atrial electrophysiology have the potential to be used to guide interventions such as catheter ablation. Calibration of these models to faithfully represent left atrial structure and function in a particular patient is challenging because electrophysiology observations obtained in the clinical setting are typically sparse and noisy, and can be difficult to register to a mesh obtained from imaging. Probabilistic approaches show promise as a way to obtain personalised models while taking account of noise, sparseness, and uncertainty. We have developed a workflow in which parameter fields are represented as Gaussian processes, and the posterior distribution is inferred using MCMC. Our workflow has been tested using synthetic data, generated from simulations where the spatial variation in model parameters is known, and we have shown that both features and parameters can be recovered from simulated sparse measurements

A Hybrid Neural Network for Graph-Based Human Pose Estimation from 2D Images

© 2013 IEEE. This paper investigates the problem of human pose estimation (HPE) from single 2-dimensional (2D) still images using a convolutional neural network (CNN). The aim was to train the CNN to analyze a 2D input image of a person to determine the person's pose. The CNN output was given in the form of a tree-structured graph of interconnected nodes representing 2D image coordinates of the person's body joints. A new data-driven tree-based model for HPE was validated and compared to the traditional anatomy-based tree-based structures. The effect of the number of nodes in anatomy-based tree-based structures on the accuracy of HPE was examined. The tree-based techniques were compared with non-tree-based methods using a common HPE framework and a benchmark dataset. As a result of this investigation, a new hybrid two-stage approach to the HPE estimation was proposed. In the first stage, a non-tree-based network was used to generate approximate results that were then passed for further refinement to the second, tree-based stage. Experimental results showed that both of the proposed methods, the data-driven tree-based model (TD_26) and the hybrid model (H_26_2B) lead to very similar results, obtaining 1% higher HPE accuracy compared to the benchmark anatomy-based model (TA_26) and 3% higher accuracy compared to the non-tree-based benchmark (NT_26_A). The best overall HPE results were obtained using the anatomy-based benchmark with the number of nodes increased from 26 to 50, which also significantly increased the computational cost

Porphyry indicator minerals and their mineral chemistry as vectoring and fertility tools

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Quality of Experience Comparison of Stereoscopic 3D Videos in Different Projection Devices: Flat Screen, Panoramic Screen and Virtual Reality Headset

The use of Stereoscopic 3D (S3D) videos has been popular in commercial markets with ongoing developments in the field of visual entertainment in recent years. A wide variety of projection methods of 3D video content is currently available, such as projection to a panoramic screen and projection of omnidirectional video content from head mounted displays using Virtual Reality (VR) technology. This article investigates the Quality of Experience (QoE) and associated Visually Induced Motion Sickness (VIMS) caused by the viewing of S3D videos. The investigations used three different projection screens: a 3D flat screen, a 3D panoramic screen in a hemispherical shaped room and a VR headset. Several assessment methods including a Simulator Sickness Questionnaire (SSQ), ElectroEncephaloGraphy (EEG), and measurement tools for eye blink rate detection were applied to measure the QoE experienced by viewers. The SSQ scores were also compared with the behavioral data such as attention and meditation levels and enjoyment ratings acquired from different video content and projection screens. The results indicate that the projection screen is a key factor affecting the level of visual fatigue, VIMS and QoE assessments, which are discussed in-depth in the article

Multi-stage arc magma evolution recorded by apatite in volcanic rocks

Gold open access fee paid by NHMProtracted magma storage in the deep crust is a key stage in the formation of evolved, hydrous arc magmas that can result in explosive volcanism and the formation of economically valuable magmatic-hydrothermal ore deposits. High magmatic water content in the deep crust results in extensive amphibole ± garnet fractionation and the suppression of plagioclase crystallization as recorded by elevated Sr/Y ratios and high Eu (high Eu/Eu*) in the melt. Here, we use a novel approach to track the petrogenesis of arc magmas using apatite trace element chemistry in volcanic formations from the Cenozoic arc of central Chile. These rocks formed in a magmatic cycle that culminated in high-Sr/Y magmatism and porphyry ore deposit formation in the Miocene. We use Sr/Y, Eu/Eu*, and Mg in apatite to track discrete stages of arc magma evolution. We apply fractional crystallization modeling to show that early-crystallizing apatite can inherit a high-Sr/Y and high-Eu/Eu* melt chemistry signature that is predetermined by amphibole-dominated fractional crystallization in the lower crust. Our modeling shows that crystallization of the in situ host-rock mineral assemblage in the shallow crust causes competition for trace elements in the melt that leads to apatite compositions diverging from bulk-magma chemistry. Understanding this decoupling behavior is important for the use of apatite as an indicator of metallogenic fertility in arcs and for interpretation of provenance in detrital studies.© 2020 The Authors Gold Open Access: This paper is published under the terms of the CC-BY license (https://creativecommons.org/licenses/by/4.0/). The attached file is the published pdf

Bilateral pedicle stress fracture in the lumbar spine of a sedentary office worker

A case of bilateral pedicle fracture in the lumbar spine of a sedentary office worker is being presented. No such case has been reported in the literature previously. Bilateral pedicle fracture is a rare entity. Few cases have been reported in literature. All the reported cases had some underlying causative factors like degenerative spine disease, previous spinal surgery or stress-related activities, e.g. athletes. Our case is a 36-year-old sedentary office worker with none of the factors mentioned. We present a case of a 36-year-old sedentary worker with long-standing low backache. There were no root tension signs. Plain radiographs were inconclusive. The patient had a CT scan. The CT scan revealed long-standing defects in the pedicles of L2 vertebra with pseudoarthrosis. Infiltration with anaesthetic relieved the symptoms. Our patient was managed conservatively with spine rehabilitation physiotherapy program. Pedicle fracture can develop due to abnormal stresses in the pedicle either because of previous spinal surgery or spondylitic changes in the spine. Bilateral pedicle fracture in the absence of these conditions is extremely rare

Home-ownership as a social norm and positional good: subjective well-being evidence from panel data

Much attention has been devoted to examining the absolute benefits of home-ownership (e.g. security and autonomy). This paper by contrast is concerned with conceptualising and testing the relative benefits of homeownership; those benefits that depend on an individual’s status in society. Home-ownership has previously been analysed as a social norm, implying that the relative benefits (costs) associated with being an owner (renter) are positively related to relevant others’ home-ownership values. The theoretical contribution of this paper is to additionally conceptualise home-ownership as a positional good, implying that the status of both home-owners and renters is negatively related to relevant others’ home-ownership consumption. The empirical contribution of this paper is to quantitatively test for these relative benefits in terms of subjective well-being. We run fixed effects regressions on three waves of the British Household Panel Study. We find that i) a strengthening of relevant others’ home-ownership values is associated with increases (decreases) in the subjective well-being of home-owners (renters), and ii) an increase in relevant others’ home-ownership consumption decreases the life satisfaction of owners but has no effect for renters. Overall our findings suggest that i) the relative benefit of home-ownership are both statistically significant and of a meaningful magnitude, and ii) homeownership is likely to be both a social norm and a positional good. Without explicitly recognising these relative benefits, policymakers risk overestimating the contribution of home-ownership to societal well-being