Observation of large-scale multi-agent based simulations

The computational cost of large-scale multi-agent based simulations (MABS) can be extremely important, especially if simulations have to be monitored for validation purposes. In this paper, two methods, based on self-observation and statistical survey theory, are introduced in order to optimize the computation of observations in MABS. An empirical comparison of the computational cost of these methods is performed on a toy problem

Projectilelike fragments from N14 beams at 15, 25, and 35 MeV/nucleon

Momentum distributions of projectilelike fragments produced in the interaction of 15, 25, and 35 MeV/nucleon N14 beams on targets of C12, Mg24, Al27, Ti48, and Ni58 have been measured. Widths and centroids of the quasielastic component of the distributions have been extracted for fragments ranging from He4 to N13. The widths are compared with published data and several theoretical predictions. The Friedman model correctly predicts the charge and isotope dependence of the widths at the highest beam energy. At 15 MeV/nucleon some deviations from the trend of the published data suggest the possibility of a different reaction mechanism for the projectile-target combinations studied in the present work

The effect of hair color on the incorporation of codeine into human hair.

The influence of melanin on the binding of xenobiotics in hair will impact the interpretation of drug concentrations determined by hair testing. The purpose of this study was to determine if codeine, as a model compound of abused drugs, would be incorporated into black, brown, blond, or red hair as a function of melanin concentration. Such data would assist in the interpretation of codeine concentrations in hair and help elucidate the potential influence of hair color on incorporation of drugs. Male and female Caucasians with black (n = 6), brown (n = 12), blond (n = 8), or red hair (n = 6) and non-Caucasians with black hair (n = 12) aged 21-40 years were enrolled in the study. Each subject was administered oral codeine phosphate syrup in a dosage of 30 mg three times a day for five days. Twenty-four hours after the end of the treatment period, a 30-mg codeine dose was administered and the subject's plasma area under the concentration time curve (AUC) for codeine was determined. Codeine and melanin were measured in the first 3 cm of hair closest to the vertex region of the scalp prior to and 1, 4, 5, 6, and 7 weeks after dosing. The quantitative and qualitative melanin profiles were determined for each subject's hair to provide an objective measure of hair color. The plasma concentrations of codeine were measured to eliminate differences in the bioavailability and clearance of codeine as factors that might account for the differences in codeine hair concentrations. The subjects were asked not to cut their hair in the vertex region of the scalp or to use any form of chemical treatment on their hair, but otherwise normal hygienic measures were permitted. The mean (+/- SE) hair codeine concentrations 5 weeks after dosing were 1429 (+/- 249) pg/mg in black hair; 208 (+/- 17) pg/mg in brown hair; 99 (+/- 10) pg/mg in blond hair; and 69 (+/- 11) in red hair pg/mg. In black hair, codeine concentrations were 2564 (+/- 170) pg/mg for Asians and 865 (+/- 162) pg/mg for Caucasians. Similar concentration relationships were observed at weeks 4, 6, and 7. A strong relationship between the hair concentrations of codeine and melanin (R(2) = 0.73) was observed. Normalization of the codeine concentration with the melanin concentration reduced the hair color differences observed. These data demonstrate that the interpretation and reporting of hair test results for codeine are influenced by hair color. After this dosing protocol, the proposed federal guideline cutoff of 200 pg/mg of codeine would result in 100% of subjects with black hair and 50% of subjects with brown hair being reported as positive, and subjects with blond or red hair would be reported as negative. The incorporation of these drugs into hair should be studied carefully in humans to ensure the appropriate interpretation of drug concentrations

Binary decay of Ni56 formed in the 32S+24Mg reaction

Fully energy-damped yields from the Mg32 reaction have been measured at center-of-mass energies of Ec.m.=51.6 and 60.5 MeV with the use of an experimental arrangement where both of the resulting heavy fragments could be detected in coincidence. Energy, velocity, and angular distributions of the reaction fragments have been determined. The cross sections prior to secondary light-particle emission have been deduced for the breakup of the compound system into different mass channels. These data are discussed in terms of two possible reaction mechanisms: fusion followed by fission and deep-inelastic orbiting

C10 and 11B+ 12C reactions from 4 to 9 MeV/nucleon

Reaction products arising from the interaction of 11B+ 12C and 10B+ 13C have been studied in the energy range 4<Elab(B)<9 MeV/nucleon. From the total fusion cross sections for the two entrance channels, the critical angular momenta have been extracted and then compared as a function of compound nucleus excitation energy. Even though a limitation in the fusion cross section was observed, no common limitation was found in the critical angular momenta for these two systems up to at least a Na23 excitation energy of 60 MeV. Above this excitation energy, the experimental uncertainties make this point less clear. Up to an excitation energy of 60 MeV in Na23, a fusion limitation based on reaching a critical density of compound nucleus states like the yrast or ''statistical'' yrast line cannot be responsible for the fusion cross section limitations observed for these entrance channels. The present data suggest that competing entrance channel processes are responsible for the observed fusion cross section limitations

Plasma Metabolomics Implicate Modified Transfer RNAs and Altered Bioenergetics in the Outcome of Pulmonary Arterial Hypertension.

BACKGROUND: -Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high mortality. METHODS: -We conducted a comprehensive study of plasma metabolites using ultra-performance liquid chromatography mass-spectrometry to (1) identify patients at high risk of early death, (2) identify patients who respond well to treatment and (3) provide novel molecular insights into disease pathogenesis. RESULTS: -53 circulating metabolites distinguished well-phenotyped patients with idiopathic or heritable PAH (n=365) from healthy controls (n=121) following correction for multiple testing (p<7.3e-5) and confounding factors, including drug therapy, renal and hepatic impairment. A subset of 20/53 metabolites also discriminated PAH patients from disease controls (symptomatic patients without pulmonary hypertension, n=139). 62 metabolites were prognostic in PAH, with 36/62 independent of established prognostic markers. Increased levels of tRNA-specific modified nucleosides (N2,N2-dimethylguanosine, N1-methylinosine), TCA cycle intermediates (malate, fumarate), glutamate, fatty acid acylcarnitines, tryptophan and polyamine metabolites and decreased levels of steroids, sphingomyelins and phosphatidylcholines distinguished patients from controls. The largest differences correlated with increased risk of death and correction of several metabolites over time was associated with a better outcome. Patients who responded to calcium channel blocker therapy had metabolic profiles similar to healthy controls. CONCLUSIONS: -Metabolic profiles in PAH are strongly related to survival and should be considered part of the deep phenotypic characterisation of this disease. Our results support the investigation of targeted therapeutic strategies that seek to address the alterations in translational regulation and energy metabolism that characterize these patients

Fusion of O16 + Ca40 at Elab(16O)=13.4 MeV/nucleon

Mass and velocity distributions have been measured for the evaporation residue and fusion-fission products from the O16+40Ca reaction at 214 MeV. Comparisons of Monte Carlo statistical evaporation simulations to the observed angle and mass dependences of the evaporation-residue velocity distributions were used to set limits on the maximum complete-fusion cross section and to extract information about the magnitude and character of incomplete-fusion processes. The extracted value of the complete fusion evaporation-residue cross section is discussed in the framework of previous results and existing models

Asymmetric fission of Ni56

Cross sections for the two-body channels populated in the S32+Mg24 reaction at Ec.m.=60.8 MeV have been measured by use of a coincidence technique which allows correction for secondary light-particle evaporation. The data show reaction yields with full equilibration of energy and mass-asymmetry coordinates. These results suggest an asymmetric fission mechanism and are contrary to what is expected from the previously proposed "orbiting" mechanism in light systems

Velocity and angular distributions of evaporation residues from induced32 reactions

Velocity distributions of mass-resolved evaporation residues from reactions of S32 with C12, Mg24, Al27, Si28, and Ca40 have been measured at bombarding energies of 194, 239, and 278 MeV using time-of-flight techniques. In all cases, the observed shifts in the velocity centroids relative to the values expected for complete fusion are consistent with a previously reported parametrization of a threshold for onset of incomplete fusion. Angular distributions were measured and total cross sections extracted for the Mg32 system at all three energies. A comparison with existing results for Mg32 at lower energies, and with other systems leading to the Ni56 compound nucleus, suggests two different types of compound-nuclear limitations to complete fusion at higher energies