SKILLED RIDERS MANAGE HORSE GAIT COMPLEXITY THROUGH A GAIT TRANSITION WHILST ALSO MAINTAINING STABLE HORSE-RIDER COORDINATION VARIABILITY

Equestrian riders aim to cue smooth transitions between horse gaits. This study aimed to investigate whether competitive horse rider (n=10) decrease horse gait regularity and increase horse-rider coordination variability in the region of a gait transition (n=6; both walk-trot, and trot-canter) relative to baseline walk, trot and canter. Resultant accelerations from IMUs affixed to the horse’s girth and rider’s pelvis were calculated. Horse gait regularity was quantified as multiscale sample entropy (MSSE) of the pelvis. Horse-rider coordination variability (Coordvar) was quantified as the standard deviation of the horse-rider continuous relative phase. Pre-transition MSSE did not increase; post-transition MSSE significantly decreased (paired t-tests; pvar were found. Therefore, horse gait or horse-rider Coordvar does not increase in a transition

The Early Royal Society and Visual Culture

Recent studies have fruitfully examined the intersection between early modern science and visual culture by elucidating the functions of images in shaping and disseminating scientific knowledge. Given its rich archival sources, it is possible to extend this line of research in the case of the Royal Society to an examination of attitudes towards images as artefacts –manufactured objects worth commissioning, collecting and studying. Drawing on existing scholarship and material from the Royal Society Archives, I discuss Fellows’ interests in prints, drawings, varnishes, colorants, images made out of unusual materials, and methods of identifying the painter from a painting. Knowledge of production processes of images was important to members of the Royal Society, not only as connoisseurs and collectors, but also as those interested in a Baconian mastery of material processes, including a “history of trades”. Their antiquarian interests led to discussion of painters’ styles, and they gradually developed a visual memorial to an institution through portraits and other visual records.AH/M001938/1 (AHRC

Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification

Coordination variability reveals the features of the 'independent seat' in competitive dressage riders.

The rider's ability to consistently coordinate their movements to their horse is a key determinant of performance in equestrian sport. This study investigated the inter-segmental coordination variability between the vertical displacement of a riding simulator and the pitch rotation of 28 competitive female dressage riders' head, trunk, pelvis, and left foot, in simulated medium and extended trot. A statistical non-parametric mapping three-way repeated-measures ANOVA investigated the influence of gait, competition level and segment on coordination variability. There was a significant main effect of gait and segment (p = 0.05), however, no significant effect of competition level. In medium trot, simulator-pelvis coupling was significantly (p < 0.001) less variable than simulator-head, -trunk, and -foot couplings. Significantly greater coordination variability of simulator-head and -foot relative to the trunk and pelvis suggested that riders can maintain stability in the saddle with their trunk and pelvis while allowing greater variability of their head and foot coupling to the simulator's vertical displacement. It is proposed that stronger coupling of the rider's pelvis relative to their other segments is one facet of the equestrian dressage skill of the independent seat. However, greater perturbations during simulated extended trot may necessitate a decrease in the independence of the rider's seat

The velocity campaign for ignition on NIF

Achieving inertial confinement fusion ignition requires a symmetric, high velocity implosion. Experiments show that we can reach 95&amp;#8201;&amp;#0177;&amp;#8201;5% of the required velocity by using a 420 TW, 1.6&amp;#8201;MJ laser pulse. In addition, experiments with a depleted uraniumhohlraum show an increase in capsule performance which suggests an additional 18&amp;#8201;&amp;#0177;&amp;#8201;5&amp;#8201;&amp;#0956;m/ns of velocity with uraniumhohlraums over goldhohlraums. Combining these two would give 99&amp;#8201;&amp;#0177;&amp;#8201;5% of the ignition velocity. Experiments show that we have the ability to tune symmetry using crossbeam transfer. We can control the second Legendre mode (P2) by changing the wavelength separation between the inner and outer cones of laser beams. We can control the azimuthal m&amp;#8201;=&amp;#8201;4 asymmetry by changing the wavelength separation between the 23.5 and 30 degree beams on NIF. This paper describes our &amp;#8220;first pass&amp;#8221; tuning the implosion velocity and shape on the National Ignition Facility laser