Reviews

Sandi Alberston-Shea. Letters for the Living: Teaching Writing in a Violent Age. (Michael Blitz and C. Mark Huribert, 1999). Susan A. Schiller. Education and the Soul: Toward a Spiritual Curriculum. (John P. Miller, 2000). Jeffrey D. Wilhelm. Radical Presence: Teaching as Contemplative Practice. (Mary Rose O\u27Reilly, 1998). Back to the Archiv

Briefwechsel

BRIEFWECHSEL Briefwechsel / Schiller, Friedrich (Public Domain) ( - ) Abbildung: Wilhelm von Humboldt ( - ) Title page ( - ) Dedication ( - ) Preface ( - ) Contents ([VII]) Vorerinnerung. Ueber Schiller und den Gang seiner Geistesentwicklung (1) Briefwechsel zwischen Schiller und Wilhelm von Humboldt ([39]) Anhang. Brief Humboldts an Körner vom 8. Juni 1805 ; [...] im Februar bis Mai 1830 ([323]) Anmerkungen ([341]) Übersichtstafel über die gesamte Korrespondenz zwischen Schiller und Humboldt ([427]) Index ([445]) ColorChart ( -

Needing NoDI (normal democratic information)? The problem of information poverty in post-industrial society

The paper addresses one of the main paradoxes of post-industrial society: information poverty. While digital divides of various types have been extensively theorized and researched, the actual condition of the information poor – those at the wrong end of socioeconomic information-divides – has not received sufficient attention. Yet if advanced nations have ‘informatized’ and thus become, at least in some measure, information societies, the plight of those lacking the definitive resource ought surely to be high on academic and political agendas. The article reviews the scattered multidisciplinary literature on the condition, confirming the iron link between economic poverty and information poverty, while also registering cultural and behavioural dimensions. Building on such work, a focused, up-to-date and, it is believed, original conception is able to be introduced, namely, information poverty as a deficiency in certain taken-for-granted categories of political and cognate information, or normal democratic information (NoDI). The new construct is then trialled in the field, among a sample of severely disadvantaged men in the city of Edinburgh, Scotland. The informants are indeed found to be, by and large, wanting in these key categories of information, an epistemic pathology that reflects and reinforces their material malaise. The article concludes that the ‘option for the poor’ – the political duty of care for the worst off – in the twenty-first century demands new modes of State action to combat an acute and increasingly salient social problem

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

Tyrosine kinases are important cellular signaling proteins that have a variety of biological activities including cell proliferation and migration. Multiple kinases are involved in angiogenesis, including receptor tyrosine kinases such as the vascular endothelial growth factor receptor. Inhibition of angiogenic tyrosine kinases has been developed as a systemic treatment strategy for cancer. Three anti-angiogenic tyrosine kinase inhibitors (TKIs), sunitinib, sorafenib and pazopanib, with differential binding capacities to angiogenic kinases were recently approved for treatment of patients with advanced cancer (renal cell cancer, gastro-intestinal stromal tumors, and hepatocellular cancer). Many other anti-angiogenic TKIs are being studied in phase I-III clinical trials. In addition to their beneficial anti-tumor activity, clinical resistance and toxicities have also been observed with these agents. In this manuscript, we will give an overview of the design and development of anti-angiogenic TKIs. We describe their molecular structure and classification, their mechanism of action, and their inhibitory activity against specific kinase signaling pathways. In addition, we provide insight into what extent selective targeting of angiogenic kinases by TKIs may contribute to the clinically observed anti-tumor activity, resistance, and toxicity. We feel that it is of crucial importance to increase our understanding of the clinical mechanism of action of anti-angiogenic TKIs in order to further optimize their clinical efficacy

Dissertatio Juris Francico-Germanici De Decimo, Aliove Denario Ex Alienatione Fundi Moventis

Trier, Univ., Jur. Diss., 1768Quam Una Cum Parergis Ex Universo Jure Pro Consequendo Juris Utriusque Doctoratu Publicæ Disputationi In Aulâ majore antiquissimæ Academiæ Trevirensis Die 19. Septembris anno 1768 Sine Præside Proposuit Joan. Wilh. Schiller, Juliacensis Ex Vollrath, Aa. Ll. & Phil. in Almâ Coloniensi primus Magister, Juris utriusque, feudalis, & S. R. I. Publico-Germanici emeritus, & in supremo Cameræ Cæsareæ judicio practicus, ab inclytâ Facultate Juridicâ post tentamen & examen rigorosum ad hoc postremum specimen admissusNicht identisch mit VD18 15212866, dort: Umfang [5] Bl., 51 S., ohne Textteil "Ad Jus Camerale S. R. I." am EndeVorlageform des Erscheinungsvermerks: Augustæ Trevirorum, Typis Eschermannianis

Dissertatio Juris Francico-Germanici De Decimo, Aliove Denario Ex Alienatione Fundi Moventis

Quam Una Cum Parergis Ex Universo Jure Pro Consequendo Juris Utriusque Doctoratu Publicae Disputationi In Aulâ majore antiquissimae Academiae Trevirensis Die 19. Septembris anno 1768 Sine Praeside Proposuit Joan. Wilh. Schiller, Juliacensis Ex Vollrath, AA. LL. & Phil. in Almâ Coloniensi primus Magister, Juris utriusque, feudalis, ... ad hoc postremum specimen admissusVorlageform des Erscheinungsvermerks: Typis EschermannianisText überw. lat., teilw. dt.Trier, Univ., Jur. Diss., 19. Sept. 176

Wallenstein : ein Trauerspiel in fünf Aufzügen / von Friedrich Schiller. Zur Aufführung eines Abends für die Bühne bearbeitet. [durch Wilhelm Vogel]

WALLENSTEIN : EIN TRAUERSPIEL IN FÜNF AUFZÜGEN / VON FRIEDRICH SCHILLER. ZUR AUFFÜHRUNG EINES ABENDS FÜR DIE BÜHNE BEARBEITET. [DURCH WILHELM VOGEL] Wallenstein : ein Trauerspiel in fünf Aufzügen / von Friedrich Schiller. Zur Aufführung eines Abends für die Bühne bearbeitet. [durch Wilhelm Vogel] (1) Einband (1) Titelblatt (10) Personen. (12) Erster Akt. (14) Zweiter Akt. (38) Dritter Akt. (67) Vierter Akt. (94) Fünfter Akt. (133) Verlagsanzeige (173