A super-spreading ewe infects hundreds with Q fever at a farmers' market in Germany

BACKGROUND: In May 2003 the Soest County Health Department was informed of an unusually large number of patients hospitalized with atypical pneumonia. METHODS: In exploratory interviews patients mentioned having visited a farmers' market where a sheep had lambed. Serologic testing confirmed the diagnosis of Q fever. We asked local health departments in Germany to identiy notified Q fever patients who had visited the farmers market. To investigate risk factors for infection we conducted a case control study (cases were Q fever patients, controls were randomly selected Soest citizens) and a cohort study among vendors at the market. The sheep exhibited at the market, the herd from which it originated as well as sheep from herds held in the vicinity of Soest were tested for Coxiella burnetii (C. burnetii). RESULTS: A total of 299 reported Q fever cases was linked to this outbreak. The mean incubation period was 21 days, with an interquartile range of 16–24 days. The case control study identified close proximity to and stopping for at least a few seconds at the sheep's pen as significant risk factors. Vendors within approximately 6 meters of the sheep's pen were at increased risk for disease compared to those located farther away. Wind played no significant role. The clinical attack rate of adults and children was estimated as 20% and 3%, respectively, 25% of cases were hospitalized. The ewe that had lambed as well as 25% of its herd tested positive for C. burnetii antibodies. CONCLUSION: Due to its size and point source nature this outbreak permitted assessment of fundamental, but seldom studied epidemiological parameters. As a consequence of this outbreak, it was recommended that pregnant sheep not be displayed in public during the 3(rd )trimester and to test animals in petting zoos regularly for C. burnetii

Concept and Architecture of a Distributed Object-Oriented Database Kernel

In this paper we describe the distributed objectoriented database kernel OMS (Object Management System), developed at CADLAB and used within the Jessi Common Framework (JCF 1 ). This kernel provides a flexible, high-performance base for today's applications like design environments, office automation, or multimedia systems. We shortly describe the internal data model (IDM) and then turn to the main topic of the paper, the distributed architecture of the OMS, where we deal with the process model, the storage of data, caching, transactions, and the eventtrigger mechanism. CADLAB is a Cooperation of the University of Paderborn and Siemens Nixdorf Information Systems AG 1 JCF is supported by the European Community as ESPRIT project number 7364 1 Introduction In the recent years, a number of new and demanding application areas for database management systems (DBMS) have evolved (CAX 2 , Office Automation, Knowledge Representation, Multimedia etc.). For those applications, conventi..