Immunological Monitoring of Osteogenesis Disorder

The study of immune responses of peripheral blood in bone regeneration for bone formation predicting complications is relevant. Studies were carried out on patients with the facial skeleton injury before and after stable osteosynthesis of the mandible in a fixing device for external fixation. Of the 136 patients, 17 people’s bone tissue regeneration has been slow. Laboratory tests were carried out before and after the operation. The studies included the study of cellular immunity, humoral immunity, phagocytosis, acute phase proteins and cytokine status. The obtained data were processed using variation statistics methods and the modified theorem of T. Bayes. The study revealed that alternating stages of regeneration of bone tissue (inflammation, proliferation of osteoblasts, collagenogenesis and ossification) are accompanied by changes in the immunological status. A comparative study of the dynamics of immunological parameters at normal and slow osteogenesis had made it possible to establish criteria for delayed consolidation of bone tissue. Prognostic criteria before the operations include increasing the concentration of IgM and decreasing the concentration of C-reactive protein, in the early postoperative period-increasing the number of leukocytes, the concentration of tumor necrosis factor, IgM, as well as reducing the number of CD45+CD3+-cells, the complement activity and the amount of lactoferrin

Clinical Implementation of Bone Regeneration and Maintenance

Bone healing and regeneration is a complex process that can become impaired by disease or the size of a bone fracture or defect. In these instances, bone grafting can be used to aid the regeneration process. Bone grafting materials can be divided into autologous, allogenic, xenogeneic, and alloplastic, and are used to fill the defect/fracture void, thereby providing stability and supporting the infiltration of surrounding bone. This book will cover the most important fundamentals of bone grafting and provide an overview of current and future trends in bone graft research. Over the course of this book, the reader will learn about the most recent advancements in bone tissue biomaterials, the different fabrication techniques of bone tissue scaffolds, and the interaction of bone graft implant materials with the body by their induced cell and tissue reactions. Overall, this book provides an insight into bone grafting and the requirements for successful bone regeneration