Primary Particle Type of the Most Energetic Fly's Eye Air Shower

The longitudinal profile of the most energetic cosmic-ray air shower measured so far, the event recorded by the Fly's Eye detector with a reconstructed primary energy of about 320 EeV, is compared to simulated shower profiles. The calculations are performed with the CORSIKA code and include primary photons and different hadron primaries. For primary photons, preshower formation in the geomagnetic field is additionally treated in detail. For primary hadrons, the hadronic interaction models QGSJET01 and SIBYLL2.1 have been employed. The predicted longitudinal profiles are compared to the observation. A method for testing the hypothesis of a specific primary particle type against the measured profile is described which naturally takes shower fluctuations into account. The Fly's Eye event is compatible with any assumption of a hadron primary between proton and iron nuclei in both interaction models, although differences between QGSJET01 and SIBYLL2.1 in the predicted profiles of lighter nuclei exist. The primary photon profiles differ from the data on a level of ~1.5 sigma. Although not favoured by the observation, the primary photon hypothesis can not be rejected for this particular event.Comment: 20 pages, 8 figures; v2 matches version accepted by Astroparticle Physic

MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with poor prognostic implications. This is partly due to a large proportion of PDACs carrying mutations in TP53, which impart gain-of-function characteristics that promote metastasis. There is evidence that microRNAs (miRNAs) may play a role in both gain-of-function TP53 mutations and metastasis, but this has not been fully explored in PDAC. Here we set out to identify miRNAs which are specifically dysregulated in metastatic PDAC. To achieve this, we utilised established mouse models of PDAC to profile miRNA expression in primary tumours expressing the metastasis-inducing mutant p53R172H and compared these to two control models carrying mutations, which promote tumour progression but do not induce metastasis. We show that a subset of miRNAs are dysregulated in mouse PDAC tumour tissues expressing mutant p53R172H, primary cell lines derived from mice with the same mutations and in TP53 null cells with ectopic expression of the orthologous human mutation, p53R175H. Specifically, miR-142-3p is downregulated in all of these experimental models. We found that DNA methyltransferase 1 (Dnmt1) is upregulated in tumour tissue and cell lines, which express p53R172H. Inhibition or depletion of Dnmt1 restores miR-142-3p expression. Overexpression of miR-142-3p attenuates the invasive capacity of p53R172H-expressing tumour cells. MiR-142-3p dysregulation is known to be associated with cancer progression, metastasis and the miRNA is downregulated in patients with PDAC. Here we link TP53 gain-of-function mutations to Dnmt1 expression and in turn miR-142-3p expression. Additionally, we show a correlation between expression of these genes and patient survival, suggesting that they may have potential to be therapeutic targets

Atmospheric Profiles at the Southern Pierre Auger Observatory and their Relevance to Air Shower Measurement

The dependence of atmospheric conditions on altitude and time have to be known at the site of an air shower experiment for accurate reconstruction of extensive air showers and their simulations. The height-profile of atmospheric depth is of particular interest as it enters directly into the reconstruction of longitudinal shower development and of the primary energy and mass of cosmic rays. For the southern part of the Auger Observatory, the atmosphere has been investigated in a number of campaigns with meteorological radio soundings and with continuous measurements of ground-based weather stations. Focussing on atmospheric depth and temperature profiles, temporal variations are described and monthly profiles are developed. Uncertainties of the monthly atmospheres that are currently applied in the Auger reconstruction are discussed.Comment: To be published in Proceedings of 29th International Cosmic Ray Conference (ICRC) 2005, Pune, Indi

Quasi-fission reactions as a probe of nuclear viscosity

Fission fragment mass and angular distributions were measured from the ^{64}Ni+^{197}Au reaction at 418 MeV and 383 MeV incident energy. A detailed data analysis was performed, using the one-body dissipation theory implemented in the code HICOL. The effect of the window and the wall friction on the experimental observables was investigated. Friction stronger than one-body was also considered. The mass and angular distributions were consistent with one-body dissipation. An evaporation code DIFHEAT coupled to HICOL was developed in order to predict reaction time scales required to describe available data on pre-scission neutron multiplicities. The multiplicity data were again consistent with one-body dissipation. The cross-sections for touch, capture and quasi-fission were also obtained.Comment: 25 pages REVTeX, 3 tables, 13 figures, submitted to Phys. Rev

Automated track recognition and event reconstruction in nuclear emulsion

The major advantages of nuclear emulsion for detecting charged particles are its submicron position resolution and sensitivity to minimum ionizing particles. These must be balanced, however, against the difficult manual microscope measurement by skilled observers required for the analysis. We have developed an automated system to acquire and analyze the microscope images from emulsion chambers. Each emulsion plate is analyzed independently, allowing coincidence techniques to be used in order to reject background and estimate error rates. The system has been used to analyze a sample of high-multiplicity Pb-Pb interactions (charged particle multiplicities ∼1100) produced by the 158 GeV/c per nucleon 208Pb beam at CERN. Automatically measured events agree with our best manual measurements on 97% of all the tracks. We describe the image analysis and track reconstruction techniques, and discuss the measurement and reconstruction uncertainties

Searching for New Physics Through AMO Precision Measurements

We briefly review recent experiments in atomic, molecular, and optical physics using precision measurements to search for physics beyond the Standard Model. We consider three main categories of experiments: searches for changes in fundamental constants, measurements of the anomalous magnetic moment of the electron, and searches for an electric dipole moment of the electron.Comment: Prepared for Comments on AMO Physics at Physica Script

Views and experiences of managing eczema:systematic review and thematic synthesis of qualitative studies*

Background: The number of qualitative studies on eczema has increased rapidly in recent years. Systematically reviewing these can provide greater understandings of people’s perceptions of eczema and eczema treatments. Objectives: We sought to systematically review and thematically synthesize qualitative studies exploring views and experiences of people with eczema and parents/carers of children with eczema. Methods: We searched MEDLINE, EMBASE, PsycINFO and CINAHL from the earliest date available to February 2019. We selected papers focusing on views and experiences of eczema and eczema treatments, and barriers/facilitators to eczema self-management. We excluded papers focusing on health service provision models or health professionals’ views. Results: We synthesized 39 papers (reporting 32 studies) from 13 countries. We developed four analytical themes: (1) Eczema not viewed as a long-term condition; (2) Significant psychosocial impact not acknowledged by others; (3) Hesitancy (patient/carer uncertainty) about eczema treatments; and (4) Insufficient information and advice. Our findings suggest that people with eczema and their carers experience frustration at having to manage a condition that is often seen by others as mundane but has significant psychosocial impact and is difficult to manage due to concerns about, and burden of, treatment. This frustration can be exacerbated by experiences of conflicting and/or insufficient information and advice from health professionals, family and others. Conclusions: Effective self-management of eczema could be supported by addressing beliefs and concerns about treatments; seeking positive ways to promote a ‘control not cure’ message; acknowledging psychosocial impacts of eczema and treatment burden; and providing clear consistent advice or signposting towards reliable information.</p