Changes in Anthropometry Measurement among Human Immunodefi ciency Virus/Acquired Immune Defi ciency Syndrome (HIV/AIDS) Patients Received Antiretroviral Treatment

ABSTRACTBackground: Estimated nearly 38.6 million people infected by HIV and 2.8 million died in 2005. Evidence suggests the existence of a very important relationship between the output and improved nutritional statusin HIV/AIDS patients. Poor nutritional status in HIV/AIDS can be caused by several factors, namely the intake and absorption of inadequate nutrition, metabolic changes, hyper metabolism, or a combination of these, changes in the gastrointestinal tract as well as interactions between drugs and nutrients. Losing weight remains on the HAART (Highly Active Antiretroviral Therapies) era, but the problems are the side effects of HAART and lipodystrophy.Objective: The purpose of this study is to determine the provision of anti- retroviral effect on changes in anthropometric values people with HIV/AIDS. Method: The study is using the one group pre-posttest design (quasi-experimental), by assessing changes in anthropometric values in subjects with HIV before and after the administration of ARVs. Analysis of the data is computerized by a computer program Result: Obtained 30 samples of the study with anthropometric changes pre and post ARVs 6 months. Theweight was 51.4 ± 9.12 to 53.6 ± 8.68 with a p-value 0.001. Body Mass Index (BMI) was 19.98 ± 3.47 into 20.84 ± 3.35 with a p-value 0.001 and upper arm circumference 24.13 ± 3.62 into 24.95±3.48 with a p-value 0.003. The provision of antiretroviral drugs for 6 months infl uences the change in nutritional status of HIV patients are assessed by anthropometric measure. Signifi cant changes in the changes body weight, BMIand upper arm circumference. Changes in anthropometric values ARV Efavirenz group and non-Efavirenz meaningful change signifi cant in skinfold thickness obtained at the value of p 0.010.Conclusion: There were no signifi cant changes in anthropometric values compared to patients with early stage HIV and advanced stage after 6 months of antiretroviral therapy.Keywords: HIV, antiretroviral drugs, anthropometric, nutritional statu

PENGARUH PEMBERIAN ANTIRETROVIRAL TERHADAP PERUBAHAN NILAI ANTROPOMETRI PENDERITA Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome.

In 2005 an estimated nearly 38,6 million people infected with HIV and 2,8 million died. Evidence suggests the existence of a very important relationship between the output and repair nutrients HIV/AIDS. Poor nutritional status in HIV/AIDS can be caused by several factors, namely the intake and absorption of inadequate nutrition, metabolic changes, hypermetabolism, or a combination of these, changes in the gastrointestinal tract as well as interactions between drugs and nutrients. Although losing weight remains on the HAART era, but the side effects of HAART and lipodystrophy to be a problem . The purpose of this study to determine whether the provision of antiretroviral effect on changes in anthropometric values people with HIV/AIDS. Research using the one group pre - post test design ( quasi- experimental ), by assessing changes in anthropometric values in subjects with HIV before and after the administration of ARV. Analysis of the data is computerized . Obtained 30 samples of the study with anthropometric changes pre and post ARVs 6 months. Weight 51,4 ± 9,12 to 53,6 ± 8,68 with a p-value 0,001, BMI 19,98 ± 3,47 into 20.84 ± 3,35 with p value 0,001 and upper arm circumference 24,13±3,62 become 24,95±3,48 with a p-value 0,003. The provision of antiretroviral drugs for 6 months influence the change in nutritional status of HIV patients are assessed by anthropometric measure. Significant changes in the changes body weight, BMI and upper arm circumference. Changes in anthropometric values ARV efavirenz group and non-efavirenz meaningful change significant in skinfold thickness obtained at the value of p 0,010. There were no significant changes in anthropometric values compared to patients with early stage HIV and advanced stage after 6 months of antiretroviral therapy

HALP Score as a Prognostic Factor of Mortality in Septic Patients at Dr. Sardjito General Hospital

Background. Sepsis is still an important health problem with a high mortality rate, an average of 44.5% in Asian countries. An easy and early biomarker is needed to determine the prognosis of sepsis. The HALP inflammation index can be used to predict mortality in malignancy conditions, yet has not been studied for sepsis.Objective. This study aimed to determine whether HALP score has a prognostic value for mortality in non malignant septic patients at Dr. Sardjito General Hospital.Methods. This was a retrospective cohort study of septic patients admitted to Internal Medicine wards between January 1, 2016 and December 31, 2018. The prognostic accuracy was evaluated by assessing the area under the receiver operating characteristic (AUC) curve. The primary outcome was mortality at the end of hospitalization. Results:. There were 125 adult patients, 104 with high HALP score (≥54,34), 21 low HALP score (<54,34), 45 patients died (36%). Patients with low HALP score were significantly at risk of death (p=0.007, OR 3.66, 95% CI 1.38-9.68) than high HALP score. Logistic regression was used to account for potential confounding factors. Low HALP score (p = 0.004, OR 4.74, 95% CI 1.63-13.76), sepsis diagnosed with quick SOFA (p = 0.006, OR 0.25, 95% CI 0.09-0.68), and multiple infections (p = 0.011, OR 2.93, 95% CI 1.28-6.73) were significantly associated with mortality in sepsis patients at Dr. Sardjito General Hospital.Conclusion. HALP score has a prognostic value of mortality in adult patients with sepsis at Dr. Sardjito General Hospita