Penerimaan Pasangan Suami Istri Terhadap Konflik Interpersonal Dalam Film “Fireproof”

Tujuan penelitian ini adalah untuk mengetahui bagaimana penerimaan pasangan suami istri terhadap konflik interpersonal dalam film “Fireproof”. Metode yang digunakan dalam penelitian ini adalah analisis penerimaan. Penelitian deskriptif kualitatif ini memberikan gambaran bagaimana informan yang merupakan pasangan suami istri menerima konflik interpersonal yang ditampilkan pada film “Fireproof”. Hasil penelitian menunjukkan ada dua poin utama, yaitu konflik interpersonal diperlukan dalam sebuah rumah tangga dan masih adanya pemahaman peran tradisional. Informan pertama memiliki penerimaan yang oppositional. Sedangkan informan kedua dan ketiga memiliki penerimaan yang negotiated

Analisa Pengaruh Kepercayaan, Kemudahan, Kualitas Informasi, Dan Tampilan Produk Terhadap Keputusan Pembelian Melalui Pemasaran Di Media Sosial (Studi Pada Pengguna Media Sosial Di Shapeharve)

Perkembangan teknologi berupa internet telah memungkinkan terjadinya transaksi jual-beli secara online. Tujuan dari penelitian ini dilakukan adalah untuk mengetahui seberapa besar pengaruh kepercayaan, kemudahan, kualitas informasi, dan tampilan produk terhadap keputusan pembelian makanan di Shapeharve melalui pemasaran di media sosial. Keputusan pembelian secara online dalam penelitian ini dilihat dari hasil pengaruh dimensi kepercayaan, kemudahan, kualitas informasi, dan tampilan produk yang dihitung menggunakan program SPSS. Teknik analisa yang digunakan dalam penelitian ini adalah regresi linier berganda dan hasilnya yang paling berpengaruh terhadap keputusan pembelian makanan di Shapeharve melalui pemasaran di media sosial adalah tampilan produk

Effect of Gold Nanorod Surface Chemistry on Cellular Response

Gold nanorods (GNRs) stabilized with cetyltrimethylammonium bromide (CTAB) and GNR functionalized via a ligand exchange method with either thiolated polyethylene glycol (PEG5000) or mercaptohexadecanoic acid (MHDA) were investigated for their stability in biological media and subsequent toxicological effects to HaCaT cells. GNR-PEG and GNR-MHDA exhibited minimal effects on cell proliferation, whereas GNR-CTAB reduced cell proliferation significantly due to the inherent toxicity of the cationic surfactant to cells. Cell uptake studies indicated relatively low uptake for GNR-PEG and high uptake for GNR-MHDA. Reverse transcriptase polymerase chain reaction (RT-PCR) revealed that GNR-PEG induced less significant and unique changes in the transcription levels of 84 genes related to stress and toxicity compared to GNR-MHDA. The results demonstrate that, although cell proliferation was not affected by both particles, there is a significant difference in gene expression in GNR-MHDA exposed cells, suggesting long-term implications for chronic exposure.Oak Ridge Institute for Science and EducationNational Science Foundation (U.S.) (NSF DMR # 0906838

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable

The value of open-source clinical science in pandemic response: lessons from ISARIC

International audienc