Statistical performance analysis with dynamic workload using S-NET

Volkmar Wieser, Philip K. F. Hölzenspies, Michael Roßbory, and Raimund Kirner, 'Statistical performance analysis with dynamic workload using S-NET'. Paper presented at the Workshop on Feedback-Directed Compiler Optimization for Multi-Core Architectures. Paris, France 23-25 January 2012In this paper the ADVANCE approach for engineering con- current software systems with well-balanced hardware ef- ficiency is adressed using the stream processing language S-Net. To obtain the cost information in the concurrent system the metrics throughput, latency, and jitter are evalu- ated by analyzing generated synthetical data as well as using an industrial related application in the future. As fall-out an Eclipse plugin for S-Net has been developed to provide sup- port for syntax highlighting, content assistance, hover help, and more, for easier and faster development. The presented results of the current work are on the one hand an indicator for the status quo of the ADVANCE vision and on the other hand used to improve the applied statistical analysis tech- niques within ADVANCE. Like the ADVANCE project, this work is still under development, but further improvements and speedups are expected in the near future

Differential regulation of interleukin-6 expression in human fibroblasts by tumor necrosis factor-α and lymphotoxin

AbstractThe treatment of human diploid fibroblasts with tumor necrosis factor (TNP)-α and with lymphotoxin (LT) is associated with induction of interleuk-in-6 (IL-6) transcripts with TNF-α being 10-fold more potent than LT. Here we report on the TNF-α/LT-induced signaling mechanisms responsible for the regulation of IL-6 gene expression in these cells. Run-on assays demonstrated that both TNF-α and LT increase IL-6 mRNA levels by transcriptional activation of this gene. Stability studies of IL-6 transcripts in fibroblasts showed that TNF-α delayed IL-6 mRNA decay but not LT. The induction of IL-6 transcripts by TNF-α and LT was not inhibited by the isoquinoline sulfonamide derivative H7. Similarly, depletion of protein kinase C (PKC) by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) did not change the ability of TNF-α and LT to induce IL-6 transcripts, demonstrating that stimulation by these agents may not be mediated by activation of PKC. Stimulation of IL-6 transcripts in fibroblasts did also not require new protein synthesis as exposure to the protein synthesis inhibitor cycloheximide (CHX) enhanced accumulation of IL-6 mRNA in the presence or absence of TNF-α or LT

IDENTIFICATION OF THE RECEPTOR FOR CONTACTINHIBIN

The results in our research about contact-dependent regulation of growth of human cells let us come to the conclusion that a defined membrane glycoprotein we called Contactinhibin is of major importance for a density-dependent down regulation of proliferation in various cell cultures. Our investigations further postulate a specific cell membrane protein receptor for contactihibin which is defective or absent in transformed cells. We are now trying to approach to the molecular nature and biochemical parameters of this receptor in order to reveal its defects in transformed cells and to find further explanations in the phenomenon of uncontrolled tumor growth

BIOSYNTHESIS OF CONTACTINHIBIN A PLASMAMEMBRANE GLYCOPROTEIN INVOLVED IN CONTACT-DEPENDENT INHIBITION OF GROWTH

Growth of normal diploid human fibroblasts jn vitro is mainly regulated by cell-cell-contacts. We have isolated a 60 - 70 kDa plasma membrane Blycoprotein, named Contactinhibin, which igs involved in the Process of contactinhibition and inhibits the growth of sparsely seeded cells in a concentration dependent, reversible and non toxic manner. Antibodies raised against Contactinhibin released confluently seeded cells from contact-inhibition, while sparsely seeded cells were not affected. The cells treated with anti-Contactinhibin antibodies showed a criss-cross morphology similar to transformed cells. Here we describe the appearance of biosynthetic precursor molecules of Contactinhibin after specific blocking of biosynthesis at an early stage

Concurrent Software Engineering on Multicore Systems Supported by Statistical Performance Analysis

This paper introduces the ADVANCE approach to engineering concurrent systems using a new component-based approach.A cost-directed tool-chain maps concurrent programs ontoemerging hardware architectures, where costs are expressed in terms ofprogrammer annotations for the throughput, latency and jitter of components. These are then synthesized using advanced statistical analysis techniques to give overall cost information about the concurrent system that can be exploitedby the hardware virtualisation layer to drive mapping and scheduling decisions.Initial performance results are presented, showing that the ADVANCE technologiesprovide a promising approach to dealing with near- and future-term complexitiesof programming heterogeneous multi-core systems

Engineering Concurrent Software Guided by Statistical Performance Analysis

This paper introduces the ADVANCE approach to engineering concurrent systems using a new component-based approach. A cost-directed tool-chain maps concurrent programs onto emerging hardware architectures, where costs are expressed in terms of programmer annotations for the throughput, latency and jitter of components. These are then synthesized using advanced statistical analysis techniques to give overall cost information about the concurrent system that can be exploited by the hardware virtualisation layer to drive mapping and scheduling decisions. Initial performance results are presented, showing that the ADVANCE technologies provide a promising approach to dealing with near- and future-term complexities of programming heterogeneous multi-core systems