1,777 research outputs found
CHARACTERISTICS AND RESIDENTIAL PATTERNS OF ENERGY-RELATED WORK FORCES IN THE NORTHERN GREAT PLAINS
The socioeconomic characteristics of construction and operating work forces at energy related facilities in the Northern Great Plains were analyzed. A primary interest was to explain differences in local hire rates and settlement patterns on the basis of characteristics of the project and site area. In general, it was found that local hire rates for operating workers can be expected to be substantially greater than for construction workers when differences in project and site characteristics are taken into account. Nonlocal construction workers were found to live in larger communities and to commute substantially greater distances to the project site than nonlocal operating workers.Labor and Human Capital,
Profile of North Dakota's Coal Mine and Electric Power Plant Operating Work Force
This report is a continuation of research on the economic and social effects of coal development in western North Dakota. The purpose of the report is to provide a profile of the characteristics of the operating work force in North Dakota's coal mines and electric power generating plants.Labor and Human Capital, Resource /Energy Economics and Policy,
Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort
Background: Pigs are mixing vessels for influenza viral reassortment but the extent of influenza transmission between swine and humans is not well understood.
Objectives: To assess whether occupational exposure to pigs is a risk factor for human infection with human and swine-adapted influenza viruses.
Methods: UK pig industry workers were frequency-matched on age, region, sampling month, and gender with a community-based comparison group from the Flu Watch study. HI assays quantified antibodies for swine and human A(H1) and A(H3) influenza viruses (titres≥40 considered seropositive and indicative of infection). Virus-specific associations between seropositivity and occupational pig exposure were examined using multivariable regression models adjusted for vaccination. Pigs on the same farms were also tested for seropositivity.
Results: 42% of pigs were seropositive to A(H1N1)pdm09. Pig industry workers showed evidence of increased odds of A(H1N1)pdm09 seropositivity compared to the comparison group, albeit with wide confidence intervals (CI), Adjusted Odds Ratio after accounting for possible cross reactivity with other swine A(H1) viruses (aOR) 25.30, 95% CI [1.44-536.34], p=0.028.
Conclusion: The results indicate that A(H1N1)pdm09 virus was common in UK pigs during the pandemic and subsequent period of human A(H1N1)pdm09 circulation, and occupational exposure to pigs was a risk factor for human infection. Influenza immunization of pig industry workers may reduce transmission and the potential for virus reassortment
Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism
BACKGROUND: Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides. Aβ is released from ectodomain cleaved amyloid precursor protein (APP) via intramembranous proteolysis by γ-secretase, a complex consisting of presenilin and a few other proteins. p23/TMP21, a member of the p24 family type I transmembrane proteins, was recently identified as a presenilin complex component capable of modulating γ-secretase cleavage. The p24 family proteins form oligomeric complexes and regulate vesicular trafficking in the early secretory pathway, but their role in APP trafficking has not been investigated. RESULTS: Here, we report that siRNA-mediated depletion of p23 in N2a neuroblastoma and HeLa cells produces concomitant knockdown of additional p24 family proteins and increases secretion of sAPP. Furthermore, intact cell and cell-free Aβ production increases following p23 knockdown, similar to data reported earlier using HEK293 cells. However, we find that p23 is not present in mature γ-secretase complexes isolated using an active-site γ-secretase inhibitor. Depletion of p23 and expression of a familial AD-linked PS1 mutant have additive effects on Aβ(42 )production. Knockdown of p23 expression confers biosynthetic stability to nascent APP, allowing its efficient maturation and surface accumulation. Moreover, immunoisolation analyses show decrease in co-residence of APP and the APP adaptor Mint3. Thus, multiple lines of evidence indicate that p23 function influences APP trafficking and sAPP release independent of its reported role in γ-secretase modulation. CONCLUSION: These data assign significance to p24 family proteins in regulating APP trafficking in the continuum of bidirectional transport between the ER and Golgi, and ascribe new relevance to the regulation of early trafficking in AD pathogenesis
Journeys through the Golgi—taking stock in a new era
The Golgi apparatus is essential for protein sorting and transport. Many researchers have long been fascinated with the form and function of this organelle. Yet, despite decades of scrutiny, the mechanisms by which proteins are transported across the Golgi remain controversial. At a recent meeting, many prominent Golgi researchers assembled to critically evaluate the core issues in the field. This report presents the outcome of their discussions and highlights the key open questions that will help guide the field into a new era
Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort.
BACKGROUND: Pigs are mixing vessels for influenza viral reassortment, but the extent of influenza transmission between swine and humans is not well understood. OBJECTIVES: To assess whether occupational exposure to pigs is a risk factor for human infection with human and swine-adapted influenza viruses. METHODS: UK pig industry workers were frequency-matched on age, region, sampling month, and gender with a community-based comparison group from the Flu Watch study. HI assays quantified antibodies for swine and human A(H1) and A(H3) influenza viruses (titres ≥ 40 considered seropositive and indicative of infection). Virus-specific associations between seropositivity and occupational pig exposure were examined using multivariable regression models adjusted for vaccination. Pigs on the same farms were also tested for seropositivity. RESULTS: Forty-two percent of pigs were seropositive to A(H1N1)pdm09. Pig industry workers showed evidence of increased odds of A(H1N1)pdm09 seropositivity compared to the comparison group, albeit with wide confidence intervals (CIs), adjusted odds ratio after accounting for possible cross-reactivity with other swine A(H1) viruses (aOR) 25·3, 95% CI (1·4-536·3), P = 0·028. CONCLUSION: The results indicate that A(H1N1)pdm09 virus was common in UK pigs during the pandemic and subsequent period of human A(H1N1)pdm09 circulation, and occupational exposure to pigs was a risk factor for human infection. Influenza immunisation of pig industry workers may reduce transmission and the potential for virus reassortment.This work was supported by joint funding from the
Biotechnology and Biological Sciences Research Council
(BBSRC), the Medical Research Council (MRC), and the
Wellcome Trust (WT) [(BBSRC/MRC/WT) BB/H014306/1;
(MRC/WT) MC_U122785833; (MRC) G0800767 and
G0600511]; Alborada Trust (to J.L.N.W.); the RAPIDD
programme of the Science & Technology Directorate (to
J.L.N.W.); US Department of Homeland Security (to
J.L.N.W.); and the Fogarty International Center at the
National Institutes of Health (to J.L.N.W.). DAI is supported
by a fellowship from the National Institute for Health
Research (NIHR) (PDF-2012-05-305) (this research is independent
and the views expressed in this publication are those
of the authors and not necessarily those of the Department of
Health or NIHR).This is the final version of the article. It first appeared from Wiley via https://doi.org//10.1111/irv.12364/abstract
An evaluation of the completeness of safety reporting in reports of complementary and alternative medicine trials
The Vehicle, Spring 1974
Table of Contents
PhotoJim Painterpage 1
Six Poems of the LandRay Schmuddepage 5
At Last to Find FreedomJann Briesacherpage 7
The Last IrisMarjorie Thoelepage 9
(Untitled)Melinda E. Recordpage 10
MenJan Schroederpage 10
ImpressionsJudy Bardpage 11
ScaredAnita Surpage 11
Loved and LostJan Schroederpage 12
Dripped-Over WaxAnita Surpage 13
The Crowded RoomWilliam E. Uteschpage 14
A River in IllinoisJames Jonespage 14
Sneeze SeasonDarlene A. Moorepage 14
ChangesMark Chianakaspage 15
PhotoJim Painterpage 16
Wedding VowsJann Briesacherpage 17
PhotoJim Painterpage 18
PhotoJim Painterpage 19
PhotoJim Painterpage 20
PhotoJim Painterpage 21
PhotoJim Painterpage 22
PhotoLarry Smyserpage 23
From Outside ColoradoRay Schmuddepage 24
Dairy QueenGayle Gleichmanpage 26
With Sunstreaks in our HairNancy Broom Brownpage 33
PhotoJim Painterpage 34
Water\u27s EdgeMarjorie Thoelepage 35
My 665th Illusion of SanityGordon Glessnerpage 36
Is it my turn to do the laundry again??? Jann Briesacherpage 38
TV Teachingbobbdoddpage 39
GuidanceWendy Diane Wielandpage 40
PhotoJim Painterpage 41
RaindropsJane Ann Beerspage 42
WaitingJan Schroederpage 42
To JonJudy Bardpage 43
One Autumn Day in 1971E. Christmanpage 43
More Surely Than Picture AlbumsMarjorie Thoelepage 44
WingspanningNancy Broom Brownpage 45
ReligionMelinda E. Recordpage 45
Rosalie StevensonMark Holleypage 46
PhotoJim Painterpage 47
WhiteShirley A. Rardinpage 48
The Beginning of a Perfect DayShirley A. Rardinpage 49
PhotoMichael Chenpage 50
Rosethorn Wall of June 17bobbdoddpage 51
ManJan Schroederpage 51
HaikuJudy Bardpage 51
You know it leaves me emptyJames Osbornepage 52
For JesseJames Osbornepage 52
EndingsMark Chianakaspage 53
ConfusionGary L. Owenspage 53
PhotoMichael Chenpage 54
PoemsJann Briesacherpage 54
Journey of just oneNancy Broom Brownpage 55
Blackbirds in IllinoisJames Jonespage 56
PoemsJann Briesacherpage 56
PhotoMichael Chenpage 57
I am a poemDarlene A. Moorepage 57
A Glimpse of ParadiseJann Briesacherpage 57
PhotoJim Painterpage 58
PoemSheila Marie Foorpage 59
In my windowBarbara S. Meyerpage 59
Section 4., Draft 3bobbdoddpage 60
PhotoJim Painterpage 61
PoemJann Briesacherpage 61
PhotoGary Deanpage 62
I amWilliam E. Uteschpage 62
To a tank-car in IllinoisJames Jonespage 63
PoemJane Ann Beerspage 63
PoemsJann Briesacherpage 63
Editor\u27s Pagepage 64https://thekeep.eiu.edu/vehicle/1031/thumbnail.jp
Effects of Interferon-α/β on HBV Replication Determined by Viral Load
Interferons α and β (IFN-α/β) are type I interferons produced by the host to control microbial infections. However, the use of IFN-α to treat hepatitis B virus (HBV) patients generated sustained response to only a minority of patients. By using HBV transgenic mice as a model and by using hydrodynamic injection to introduce HBV DNA into the mouse liver, we studied the effect of IFN-α/β on HBV in vivo. Interestingly, our results indicated that IFN-α/β could have opposite effects on HBV: they suppressed HBV replication when viral load was high and enhanced HBV replication when viral load was low. IFN-α/β apparently suppressed HBV replication via transcriptional and post-transcriptional regulations. In contrast, IFN-α/β enhanced viral replication by inducing the transcription factor HNF3γ and activating STAT3, which together stimulated HBV gene expression and replication. Further studies revealed an important role of IFN-α/β in stimulating viral growth and prolonging viremia when viral load is low. This use of an innate immune response to enhance its replication and persistence may represent a novel strategy that HBV uses to enhance its growth and spread in the early stage of viral infection when the viral level is low
The Vehicle, Spring 1974
Table of Contents
PhotoJim Painterpage 1
Six Poems of the LandRay Schmuddepage 5
At Last to Find FreedomJann Briesacherpage 7
The Last IrisMarjorie Thoelepage 9
(Untitled)Melinda E. Recordpage 10
MenJan Schroederpage 10
ImpressionsJudy Bardpage 11
ScaredAnita Surpage 11
Loved and LostJan Schroederpage 12
Dripped-Over WaxAnita Surpage 13
The Crowded RoomWilliam E. Uteschpage 14
A River in IllinoisJames Jonespage 14
Sneeze SeasonDarlene A. Moorepage 14
ChangesMark Chianakaspage 15
PhotoJim Painterpage 16
Wedding VowsJann Briesacherpage 17
PhotoJim Painterpage 18
PhotoJim Painterpage 19
PhotoJim Painterpage 20
PhotoJim Painterpage 21
PhotoJim Painterpage 22
PhotoLarry Smyserpage 23
From Outside ColoradoRay Schmuddepage 24
Dairy QueenGayle Gleichmanpage 26
With Sunstreaks in our HairNancy Broom Brownpage 33
PhotoJim Painterpage 34
Water\u27s EdgeMarjorie Thoelepage 35
My 665th Illusion of SanityGordon Glessnerpage 36
Is it my turn to do the laundry again??? Jann Briesacherpage 38
TV Teachingbobbdoddpage 39
GuidanceWendy Diane Wielandpage 40
PhotoJim Painterpage 41
RaindropsJane Ann Beerspage 42
WaitingJan Schroederpage 42
To JonJudy Bardpage 43
One Autumn Day in 1971E. Christmanpage 43
More Surely Than Picture AlbumsMarjorie Thoelepage 44
WingspanningNancy Broom Brownpage 45
ReligionMelinda E. Recordpage 45
Rosalie StevensonMark Holleypage 46
PhotoJim Painterpage 47
WhiteShirley A. Rardinpage 48
The Beginning of a Perfect DayShirley A. Rardinpage 49
PhotoMichael Chenpage 50
Rosethorn Wall of June 17bobbdoddpage 51
ManJan Schroederpage 51
HaikuJudy Bardpage 51
You know it leaves me emptyJames Osbornepage 52
For JesseJames Osbornepage 52
EndingsMark Chianakaspage 53
ConfusionGary L. Owenspage 53
PhotoMichael Chenpage 54
PoemsJann Briesacherpage 54
Journey of just oneNancy Broom Brownpage 55
Blackbirds in IllinoisJames Jonespage 56
PoemsJann Briesacherpage 56
PhotoMichael Chenpage 57
I am a poemDarlene A. Moorepage 57
A Glimpse of ParadiseJann Briesacherpage 57
PhotoJim Painterpage 58
PoemSheila Marie Foorpage 59
In my windowBarbara S. Meyerpage 59
Section 4., Draft 3bobbdoddpage 60
PhotoJim Painterpage 61
PoemJann Briesacherpage 61
PhotoGary Deanpage 62
I amWilliam E. Uteschpage 62
To a tank-car in IllinoisJames Jonespage 63
PoemJane Ann Beerspage 63
PoemsJann Briesacherpage 63
Editor\u27s Pagepage 64https://thekeep.eiu.edu/vehicle/1031/thumbnail.jp
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