21 research outputs found

    Innovative Downhole Tools for Cause Study and Main tenance in Deep Geothermal Energy

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    The potential of geothermal energy is undoubted. While shallow geothermal energy can be used with minimal risk but with small energy production, deep geothermal energy has still some barriers to overcome. Among high drilling costs, production rates below the expected range make it hard to compete for deep geothermal energy with other energy sources. Additionally, the risks of induced seismic events or uncontrolled water leaks leading to ground lifting obstruct the acceptance and promotion of this technology. With a long history in developing remote-handling tools e.g. for inspection and maintenance of pipes and sewers, the Institute for Applied Computer Science (IAI) started in 2010 with the work on specialized tools for deep geothermal boreholes. The overall target of this project is to provide suitable tools for studying geothermal boreholes, especially with regard to faults and their effects on efficiency and safety of geothermal projects as well as maintenance to recover geothermal boreholes showing respective defects. Since the constraints downhole are challenging, the technical solutions require a high grade of innovation and specialization and are therefore expensive. In order to realize solutions with high quality embodied in affordable tools, a system platform approach is pursued. This approach allows reusing and advancement of basic tool components for a wide range of different applications. When discovering new spaces, it is a human and scientific desire to get visual impressions from the unknown environment. Therefore, following the example of pictures from the Mars, the first functional example of the system platform for downhole tools, is a video inspection system called GeoKam. Besides the obvious wish for a literal insight in deep geothermal boreholes, the video application provides several advantages. Since it is a complex operation to record, process and transfer live-videos from deep geothermal boreholes, the device shows the performance of the system platform regarding the main challenges of downhole operation: high temperatures, high pressures, small spaces and long distance tool handling and data transfer via wirelines. Beyond that, a live downhole video stream is a necessary precondition for maintenance operations as leakage repair

    A Novel Receiver Design for Energy Packet‐Based Dispatching

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    A steadily growing share of renewable energies with fluctuating and decentralized generation as well as rising peak loads require novel solutions to ensure the reliability of electricity supply. More specifically, grid stability is endangered by equally relevant line constraints and battery capacity limits. In this light, energy packet-based dispatching with power signal dual modulation has recently been introduced as an innovative solution. However, this approach assumes a central synchronicity provision unit for energy packet (EP) dispatching. To overcome this assumption, the present article\u27s main contribution is a design of an EP receiver which recovers the required synchronicity information directly from the received signal itself. Key implementation aspects are discussed in detail. By means of a direct current (DC) grid example, simulation results show the performance and applicability of the proposed novel receiver for packet-based energy dispatching

    Personalized [177Lu]Lutetium-PSMA Therapy for Patients with Pre-Treated Castration-Resistant Prostate Cancer: A Single Institution Experience from a Comprehensive Cancer Centre

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    Castration resistant prostate cancer (CRPC) is characterized by an aggressive biological behavior with a relatively short survival time, especially in progressive tumors pretreated with new hormonal agents and taxane chemotherapy. [177Lu]-Lutetium-PSMA (Lu-PSMA) treatment has proven efficacy in these patients. However, around 30% of the CRPC patients do not benefit from Lu-PSMA treatment, and little is known about predictive factors for treatment success if Lu-PSMA is offered in an individualized approach based on clinical and laboratory features. In this monocentric retrospective study, 86 CRPC patients receiving Lu-PSMA treatment were evaluated. The focus of the study was to describe clinical factors at baseline and during early treatment that are related to overall survival (OS). In addition, PSMA PET/CT-, PSA-response, and safety and tolerability (CTCAE adverse event reporting) were assessed. Efficacy endpoints were calculated using stratified Kaplan–Meier methods and Cox regression models. Mean applied dose was 17.7 GBq (mean 5.3 ± 1.1 GBq per cycle) with an average of 3.6 (range 1–8) therapy cycles. Patients were followed up for a mean of 12.4 months (range 1–39). The median OS was 15 months (95% CI 12.8–17.2). The best overall response rate in patients assessed with PSMA PET/CT and PSA response was 27.9%, and 50.0% had at least stable disease. Nine patients had a ≄grade 3 adverse event with anemia being the most frequent adverse event. Positive predictors for prolonged OS from baseline parameters were pre-treatment hemoglobin level of ≄10 g/dL and a lower PSA values at treatment start, while the presence of visceral or liver metastases were not significantly associated with worse prognoses in this cohort. With careful patient selection, an individualized Lu-PSMA treatment approach is feasible and patients with dose-limiting factors or visceral metastases should be included in prospective trials

    Correction to: Navigating tensions in climate change-related planned relocation (Ambio, (2024), 53, 9, (1262-1266), 10.1007/s13280-024-02035-2)

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    In the original published article, the author names “Friedrich Nikolaus Neu, Cheikh Tidiane Wade and Alberto Preato” were incorrectly written as “Frederich Neu, Cheikh Wade and Alberto Praeto”. Also the ORCIDs for the below authors were updated in this correction. Giovanna Gini Hanne Wiegel Friedrich Nikolaus Neu Ann-Christine Link Claudia Fry Tammy Tabe Olumuyiwa Adegun Cheikh Tidiane Wade Erica Rose Bower Sarah Koeltzow Rachel Harrington-Abrams Carolien Jacobs Kees van der Geest Narjes Zivdar Ryan Alaniz David Durand-Delacre Melanie Pill Himanshu Shekhar Olivia Yates Md Abdul Awal Khan Frank Kwesi Nansam-Aggrey Kwame Nitri Owusu-Daaku Merewalesi Yee The original article has been corrected.</p
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