2,367 research outputs found
LISA Response Function and Parameter Estimation
We investigate the response function of LISA and consider the adequacy of its
commonly used approximation in the high-frequency range of the observational
band. We concentrate on monochromatic binary systems, such as white dwarf
binaries. We find that above a few mHz the approxmation starts becoming
increasingly inaccurate. The transfer function introduces additional amplitude
and phase modulations in the measured signal that influence parameter estmation
and, if not properly accounted for, lead to losses of signal-to-noise ratio.Comment: 4 pages, 2 figures, amaldi 5 conference proceeding
Structural Change in (Economic) Time Series
Methods for detecting structural changes, or change points, in time series
data are widely used in many fields of science and engineering. This chapter
sketches some basic methods for the analysis of structural changes in time
series data. The exposition is confined to retrospective methods for univariate
time series. Several recent methods for dating structural changes are compared
using a time series of oil prices spanning more than 60 years. The methods
broadly agree for the first part of the series up to the mid-1980s, for which
changes are associated with major historical events, but provide somewhat
different solutions thereafter, reflecting a gradual increase in oil prices
that is not well described by a step function. As a further illustration, 1990s
data on the volatility of the Hang Seng stock market index are reanalyzed.Comment: 12 pages, 6 figure
Activation of the LH receptor up regulates the type 2 adiponectin receptor in human granulosa cells
PURPOSE: Adiponectin is a predominantly adipocyte-derived hormone which influences insulin sensitivity and energy homeostasis through at least two receptors, AdipoR1 and AdipoR2. In animal models, adiponectin may regulate ovarian steroidogenesis, folliculogenesis, and ovulation. The receptors AdipoR1 and AdipoR2 are present in the human ovary, but their regulation is unknown. In these studies, we determined the effects of LH receptor activation on the expression and function of the two adiponectin receptors in human granulosa cells. METHODS: Granulosa cells were obtained at the time of oocyte retrieval in women undergoing in vitro fertilization (IVF). Cells were isolated and cultured for 48 h in DMEM/F12 medium with 5 % FBS and 50 ug/ml gentamicin. Medium was changed to low serum for 12 h and cells were treated with hCG (100 ng/ml), forskolin (30 μMol/L), or FSH (1 IU/ml) for 24 h for mRNA experiments. mRNA was isolated and RT PCR was performed using Taqman assays and quantification with the delta delta CT method. For immunocytochemistry, cells were grown on chamber slides and treated with hCG for 1 to 24 h and fixed with acetone. ICC was performed with polyclonal rabbit primary antibodies followed by alexa fluor goat anti-rabbit antibody and imaging with a fluorescence microscope and Zeiss software analysis. 3β-hydroxysteroid dehydrogenase (3βHSD) enzyme activity was determined by measuring the progesterone produced when cells were provided with an excess of 22-hydroxy-cholesterol as substrate following an incubation with hCG (1 IU/ml) and/or adiponectin (10 ng/ml). Progesterone content in the media was determined by ELISA. RESULTS: Messenger RNA for the two Adiponectin receptors is differentially regulated by activation of LHR with hCG treatment. AdipoR2 was increased nearly 4-fold (p < 0.05), whereas AdipoR1 expression was not changed by hCG treatment. Treatment with either FSH or forskolin (an activator of cAMP) had similar effects. Basal AdipoR2 protein was fairly low in granulosa cells in culture however treatment of cells with hCG resulted in a discernible increase in immunodetectable cytoplasmic protein as early as 6 h after treatment and was maintained for at least 24 h. The number of cells positive for AdipoR2 at 6 h increased from a basal of 20 % to almost 60 % (p < 0.05). Adiponectin treatment of hCG-primed cells resulted in increased 3βHSD activity by approximately 60 % over hCG alone and more than 3-fold over basal levels. CONCLUSIONS: AdipoR2 is regulated by the LH receptor function via a cAMP dependant mechanism. Increased expression of adipoR2 prior to and following ovulation may contribute to enhanced 3βHSD activity and increased progesterone secretion by the corpus luteum of the ovary. Dysregulation of adiponectin that may occur with PCOS may impair normal progesterone production
Phase ordering in bulk uniaxial nematic liquid crystals
The phase-ordering kinetics of a bulk uniaxial nematic liquid crystal is
addressed using techniques that have been successfully applied to describe
ordering in the O(n) model. The method involves constructing an appropriate
mapping between the order-parameter tensor and a Gaussian auxiliary field. The
mapping accounts both for the geometry of the director about the dominant
charge 1/2 string defects and biaxiality near the string cores. At late-times t
following a quench, there exists a scaling regime where the bulk nematic liquid
crystal and the three-dimensional O(2) model are found to be isomorphic, within
the Gaussian approximation. As a consequence, the scaling function for
order-parameter correlations in the nematic liquid crystal is exactly that of
the O(2) model, and the length characteristic of the strings grows as
. These results are in accord with experiment and simulation. Related
models dealing with thin films and monopole defects in the bulk are presented
and discussed.Comment: 21 pages, 3 figures, REVTeX, submitted to Phys. Rev.
Let me Google that for you:a time series analysis of seasonality in internet search trends for terms related to foot and ankle pain
BACKGROUND: The analysis of internet search traffic may present the opportunity to gain insights into general trends and patterns in information seeking behaviour related to medical conditions at a population level. For prevalent and widespread problems such as foot and ankle pain, this information has the potential to improve our understanding of seasonality and trends within these conditions and their treatments, and may act as a useful proxy for their true incidence/prevalence characteristics. This study aimed to explore seasonal effects, general trends and relative popularity of internet search terms related to foot and ankle pain over the past decade. METHODS: We used the Google Trends tool to obtain relative search engine traffic for terms relating to foot and ankle pain and common treatments from Google search and affiliated pages for major northern and southern hemisphere English speaking nations. Analysis of overall trends and seasonality including summer/winter differences was carried out on these terms. RESULTS: Searches relating to general foot pain were on average 3.4 times more common than those relating to ankle pain, and twice as common as searches relating to heel pain. Distinct seasonal effects were seen in the northern hemisphere, with large increases in search volumes in the summer months compared to winter for foot (p = 0.004, 95 % CI [22.2–32.1]), ankle (p = 0.0078, 95 % CI [20.9–35.5]), and heel pain (p = 0.004, 95 % CI [29.1–45.6]). These seasonal effects were reflected by data from Australia, with the exception of ankle pain. Annual seasonal effects for treatment options were limited to terms related to foot surgery and ankle orthoses (p = 0.031, 95 % CI [3.5–20.9]; p = 0.004, 95 % CI [7.6–25.2] respectively), again increasing in the summer months. CONCLUSIONS: A number of general trends and annual seasonal effects were found in time series internet search data for terms relating to foot and ankle pain. This data may provide insights into these conditions at population levels. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13047-015-0074-9) contains supplementary material, which is available to authorized users
Perturbation Expansion in Phase-Ordering Kinetics: II. N-vector Model
The perturbation theory expansion presented earlier to describe the
phase-ordering kinetics in the case of a nonconserved scalar order parameter is
generalized to the case of the -vector model. At lowest order in this
expansion, as in the scalar case, one obtains the theory due to Ohta, Jasnow
and Kawasaki (OJK). The second-order corrections for the nonequilibrium
exponents are worked out explicitly in dimensions and as a function of the
number of components of the order parameter. In the formulation developed
here the corrections to the OJK results are found to go to zero in the large
and limits. Indeed, the large- convergence is exponential.Comment: 20 pages, no figure
Mesoscopic Analysis of Structure and Strength of Dislocation Junctions in FCC Metals
We develop a finite element based dislocation dynamics model to simulate the
structure and strength of dislocation junctions in FCC crystals. The model is
based on anisotropic elasticity theory supplemented by the explicit inclusion
of the separation of perfect dislocations into partial dislocations bounding a
stacking fault. We demonstrate that the model reproduces in precise detail the
structure of the Lomer-Cottrell lock already obtained from atomistic
simulations. In light of this success, we also examine the strength of
junctions culminating in a stress-strength diagram which is the locus of points
in stress space corresponding to dissolution of the junction.Comment: 9 Pages + 4 Figure
Critical Dynamics of a Vortex Loop Model for the Superconducting Transition
We calculate analytically the dynamic critical exponent measured in
Monte Carlo simulations for a vortex loop model of the superconducting
transition, and account for the simulation results. In the weak screening
limit, where magnetic fluctuations are neglected, the dynamic exponent is found
to be . In the perfect screening limit, . We relate
to the actual value of observable in experiments and find that , consistent with some experimental results
Optimal statistic for detecting gravitational wave signals from binary inspirals with LISA
A binary compact object early in its inspiral phase will be picked up by its
nearly monochromatic gravitational radiation by LISA. But even this innocuous
appearing candidate poses interesting detection challenges. The data that will
be scanned for such sources will be a set of three functions of LISA's twelve
data streams obtained through time-delay interferometry, which is necessary to
cancel the noise contributions from laser-frequency fluctuations and
optical-bench motions to these data streams. We call these three functions
pseudo-detectors. The sensitivity of any pseudo-detector to a given sky
position is a function of LISA's orbital position. Moreover, at a given point
in LISA's orbit, each pseudo-detector has a different sensitivity to the same
sky position. In this work, we obtain the optimal statistic for detecting
gravitational wave signals, such as from compact binaries early in their
inspiral stage, in LISA data. We also present how the sensitivity of LISA,
defined by this optimal statistic, varies as a function of sky position and
LISA's orbital location. Finally, we show how a real-time search for inspiral
signals can be implemented on the LISA data by constructing a bank of templates
in the sky positions.Comment: 22 pages, 15 eps figures, Latex, uses iopart style/class files. Based
on talk given at the 8th Gravitational Wave Data Analysis Workshop,
Milwaukee, USA, December 17-20, 2003. Accepted for publication in Class.
Quant. Gra
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