Diagnosis and treatment of Staphylococcus aureus-induced infections of the skin and mucous membranes: S2k and IDA guidelines

Schöfer H, Bruns R, Effendy I, et al. Diagnosis and treatment of Staphylococcus aureus-induced infections of the skin and mucous membranes: S2k and IDA guidelines. Chemotherapie-Journal (CTJ). 2011;20(5):141-156

Streptokokkeninfektionen der Haut und Schleimhäute

Tschachler E, Brockmeyer N, Effendy I, et al. Streptococcal infections of the skin and mucous membranes. Journal der Deutschen Dermatologischen Gesellschaft (JDDG). 2007;5(6):527-532.Dt. Version erschienen u.d.T.: Streptokokkeninfektionen der Haut und Schleimhäute ([https://doi.org/10.1111/j.1610-0387.2007.06287_supp.x](https://doi.org/10.1111/j.1610-0387.2007.06287_supp.x)

Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases

Pathogens, expressing metallo-β-lactamases (MBLs), become resistant against most β-lactam antibiotics. Besides the dragging search for new antibiotics, development of MBL inhibitors would be an alternative weapon against resistant bacterial pathogens. Inhibition of resistance enzymes could restore the antibacterial activity of β-lactams. Various approaches to MBL inhibitors are described; among others, the promising motif of a zinc coordinating thiol moiety is very popular. Nevertheless, since the first report of a thiol-based MBL inhibitor (thiomandelic acid) in 2001, no steps in development of thiol based MBL inhibitors were reported that go beyond clinical isolate testing. In this study, we report on the synthesis and biochemical characterization of thiol-based MBL inhibitors and highlight the challenges behind the development of thiol-based compounds, which exhibit good in vitro activity toward a broad spectrum of MBLs, selectivity against human off-targets, and reasonable activity against clinical isolates

Inhibitive Effect of antibiotic-loaded beads to cure chronic osteomyelitis in developing country:Hand-made vs commercial beads

Local antibiotic-loaded beads have been approved for standard treatment of orthopaedic pathogens, especially chronic osteomyelitis. Septopal (R), the only commercial local antibiotic bead available on the market, is expensive and contains only gentamicin. This study aimed to compare the in vitro inhibitive effect of hand-made antibiotic-loaded beads (fosfomycin-sodium) with Septopal (R) for ten bacteria[ strains of chronic osteomyelitis by diffussion technique at various indicated time points. The results showed that Septopal (R) could inhibit all bacterial strains except CNS 7334 and CNS 7391. Hand-made fosfomycin beads were only slightly effective in two of the ten bacterial strains is used (Staphylococcus aureus 7323 and CNS 7391). In conclusion, this study demonstrated that Septopal (R) can inhibit common orthopaedic pathogens better than hand-made beads in vitro study, however, fosfomycin concentrations required to kill orthopedic implant related bacterial strains are high and its release from hand-made beads is too low to be considered efective when compared with Septopal beads.</p