1 research outputs found
Brassica oleracea var. italica extract reducing free radicals and inflammation initiated by an exposure to cigarette smoke
Introduction: Herbal extracts are often administered to
cigarette smokers to prevent excessive free radicals. These include
Brassica oleracea var. Italica, known to contain high antioxidant
flavonoids and selenium micronutrients. Therefore, this study
aims to determine the efficacy of Brassica oleracea var extract.
italica in reducing the free radicals and inflammation present in
experimental animals exposed to cigarette smoke.
Design and Methods: This research was conducted based on
an experimental method using a randomized controlled trial
(RCT) for 21 days. The animals used were divided into six groups
(negative control, positive control, and four treatments).
Particularly, the positive control and treatment groups were
exposed to cigarette smoke for 2 minutes, twice a day, at 50 PPM
CO levels. The treatment groups were administered the extract at
different doses (0.5 ml; 0.75 ml; 1 ml; 1.25 ml), before assessing
the blood level of malondialdehyde and C-Reactive Protein.
Result: The results showed the tendency for exposure to
smoke to increase the number of free radicals and stimulate
inflammation responses in the body (P<0,05). In addition, a strong
correlation between variables was established (p=0.000; r=0.713).
Conclusions: Broccoli extracts (Brassica oleracea L. var.
Italica) administration has the potential to cause a decline in the
two aspects, including free radicals and inflammation responses
resulting from exposure to cigarette smoke