Quality-testing the legal Internet: finding law with the SOSIG Law Gateway

English language version of a preprint of an article by Steven Whittle, Information Systems Manager at the Institute of Advanced Legal Studies, published in Recht Bibliothek Dokumentation, the journal of the AjBD Arbeitsgemeinschaft für juristisches Bibliotheks-und Dokumentationswese

Finding not seeking: Law on the UK’s Social Science Information Gateway

Unpublished article on the Social Science Information Gateway by Steve Whittle, Information Systems Manager at the Institute of Advanced Legal Studie

"Magic in the web of it": more developments in SOSIG

Preprint of a brief article by Steve Whittle, Information Systems Manager at the Institute of Advanced Legal Studies, published in UK Centre for Legal Education’s Directions in Legal Education Newsletter

Sense and Searchability: developing the SOSIG Law Gateway

Preprint of a brief article by Steve Whittle, Information Systems Manager at the Institute of Advanced Legal Studies, published in UK Centre for Legal Education’s Directions in Legal Education Newsletter, spring 2001

Launching IALS Digital: Connections and Collaboration

During its 70th Anniversary celebrations the Institute of Advanced Legal Studies, School of Advanced Study, University of London launched IALS Digital - a new name for established and evolving online services at IALS, bringing together resources, opportunities for new legal information initiatives, research projects and partnerships, and delivering support for digital legal scholarship. This paper, developed from presentations at the launch in November 2017, reports on the event and describes what the Institute plans to achieve through IALS Digital – explaining what it is, how it has developed and how it fits well with the IALS national role in the promotion and facilitation of legal research

Telling Legal Backstories – making historic case papers from the Judicial Committee of the Privy Council available to all online

The Institute of Advanced Legal Studies holds copies of case papers of appeals to the Judicial Committee of the Privy Council (JCPC). Steven Whittle describes the recent open access initiative at the IALS, working with BAILII to provide online access to historic case papers of appeals from over 35 countries from the period 1935 to 1985. These are cases of the highest importance in the legal development of each of the countries and to the development of common law shared by many countries worldwide

FIT for purpose – the new FLARE Index to Treaties

The FLARE Index to Treaties which was launched in March 2009 on the Institute of Advanced Legal Studies web server, was conceived to fill a gap in the range of information finding tools available on the internet for the international lawyer. It is a fully searchable database indexing and listing over 1,500 of the most significant multilateral treaties concluded from 1856 onwards. This article describes the background to the development, the various ways in which the service can be used and technical issues in its construction and use.Preprint of an article by Dr Peter Clinch, Senior Subject Librarian for Law, Cardiff University, Wales, UK and Steven Whittle, Information Systems Manager, Institute of Advanced Legal Studies, University of London published online by LLRX.co

Modifying Hofstee standard setting for assessments that vary in difficulty, and to determine boundaries for different levels of achievement.

BACKGROUND: Fixed mark grade boundaries for non-linear assessment scales fail to account for variations in assessment difficulty. Where assessment difficulty varies more than ability of successive cohorts or the quality of the teaching, anchoring grade boundaries to median cohort performance should provide an effective method for setting standards. METHODS: This study investigated the use of a modified Hofstee (MH) method for setting unsatisfactory/satisfactory and satisfactory/excellent grade boundaries for multiple choice question-style assessments, adjusted using the cohort median to obviate the effect of subjective judgements and provision of grade quotas. RESULTS: Outcomes for the MH method were compared with formula scoring/correction for guessing (FS/CFG) for 11 assessments, indicating that there were no significant differences between MH and FS/CFG in either the effective unsatisfactory/satisfactory grade boundary or the proportion of unsatisfactory graded candidates (p > 0.05). However the boundary for excellent performance was significantly higher for MH (p < 0.01), and the proportion of candidates returned as excellent was significantly lower (p < 0.01). MH also generated performance profiles and pass marks that were not significantly different from those given by the Ebel method of criterion-referenced standard setting. CONCLUSIONS: This supports MH as an objective model for calculating variable grade boundaries, adjusted for test difficulty. Furthermore, it easily creates boundaries for unsatisfactory/satisfactory and satisfactory/excellent performance that are protected against grade inflation. It could be implemented as a stand-alone method of standard setting, or as part of the post-examination analysis of results for assessments for which pre-examination criterion-referenced standard setting is employed

Recurrent Plasmodium falciparum Malaria Infections in Kenyan Children Diminish T-Cell Immunity to Epstein Barr Virus Lytic but Not Latent Antigens

Plasmodium falciparum malaria (Pf-malaria) and Epstein Barr Virus (EBV) infections coexist in children at risk for endemic Burkitt's lymphoma (eBL); yet studies have only glimpsed the cumulative effect of Pf-malaria on EBV-specific immunity. Using pooled EBV lytic and latent CD8+ T-cell epitope-peptides, IFN-γ ELISPOT responses were surveyed three times among children (10 months to 15 years) in Kenya from 2002–2004. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated in association with Pf-malaria exposure, defined at the district-level (Kisumu: holoendemic; Nandi: hypoendemic) and the individual-level. We observed a 46% decrease in positive EBV lytic antigen IFN-γ responses among 5–9 year olds residing in Kisumu compared to Nandi (PR: 0.54; 95% CI: 0.30–0.99). Individual-level analysis in Kisumu revealed further impairment of EBV lytic antigen responses among 5–9 year olds consistently infected with Pf-malaria compared to those never infected. There were no observed district- or individual-level differences between Pf-malaria exposure and EBV latent antigen IFN-γ response. The gradual decrease of EBV lytic antigen but not latent antigen IFN-γ responses after primary infection suggests a specific loss in immunological control over the lytic cycle in children residing in malaria holoendemic areas, further refining our understanding of eBL etiology

A native chromatin purification system for epigenomic profiling in Caenorhabditis elegans

High-resolution mapping of chromatin features has emerged as an important strategy for understanding gene regulation and epigenetic inheritance. We describe an in vivo tagging system coupled to chromatin purification for genome-wide epigenetic profiling in Caenorhabditis elegans. In this system, we coexpressed the Escherichia coli biotin ligase enzyme (BirA), together with the C. elegans H3.3 gene fused to BioTag, a 23-amino-acid peptide serving as a biotinylation substrate for BirA, in vivo in worms. We found that the fusion BioTag::H3.3 was efficiently biotinylated in vivo. We developed methods to isolate chromatin under different salt extraction conditions, followed by affinity purification of biotinylated chromatin with streptavidin and genome-wide profiling with microarrays. We found that embryonic chromatin is differentially extracted with increasing salt concentrations. Interestingly, chromatin that remains insoluble after washing in 600 mM salt is enriched at 5′ and 3′ ends, suggesting the presence of large protein complexes that render chromatin insoluble at transcriptional initiation and termination sites. We also found that H3.3 landscapes from these salt fractions display consistent features that correlate with gene activity: the most highly expressed genes contain the most H3.3. This versatile two-component approach has the potential of facilitating genome-wide chromatin dynamics and regulatory site identification in C. elegans