La Produccion de Alimentos y la Crisis Energetica

By the year 1975, the world population is expected to reach 4 billion human beings. As the population continues to grow, there will be growing concern about how to prevent or avoid large-scale famine. Concurrently, an energy crisis (caused by fuel shortages and high fuel prices) is expected as the world's population continues  as reserves of the non-renewable resource of fuels are rapidly depleting. The energy crisis is also expected to have a significant impact on production technology,on food production technology in the United States and on the "green revolution"  because both crop production systems depend on large inputs of energySe espera que para el año 1975 la poblacion mundial alcance la cifra de 4 billones de seres humanos. Segun continue creciendo la poblacion crecera la preocupacion sobre como prevenir o evitar una hambruna en gran escala. Concurrentemente se espera una crisis energetica (causada por escasez de combustibles y precios altos de los mismos) al paso que se vayan agotando rapidamente las reservas del recurso no renovable que son los combustibles de origen fosil. Se espera tambien que la crisis energetica tenga un impacto significativo en la tecnologfa de la produccion de alimentos en los Estados Unidos y en la "revolucion verde" porque ambos sistemas de produccion de cosechas dependen de grandes insumos de energia

Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts

There are nearly 65 million people with chronic heart failure (CHF) globally, with no treatment directed at the pathologic cause of the disease, the loss of functioning cardiomyocytes. We have an allogeneic cardiac patch comprised of cardiomyocytes and human fibroblasts on a bioresorbable matrix. This patch increases blood flow to the damaged heart and improves left ventricular (LV) function in an immune competent rat model of ischemic CHF. After 6 months of treatment in an immune competent Yucatan mini swine ischemic CHF model, this patch restores LV contractility without constrictive physiology, partially reversing maladaptive LV and right ventricular remodeling, increases exercise tolerance, without inducing any cardiac arrhythmias or a change in myocardial oxygen consumption. Digital spatial profiling in mice with patch placement 3 weeks after a myocardial infarction shows that the patch induces a CD45pos immune cell response that results in an infiltration of dendritic cells and macrophages with high expression of macrophages polarization to the anti-inflammatory reparative M2 phenotype. Leveraging the host native immune system allows for the potential use of immunomodulatory therapies for treatment of chronic inflammatory diseases not limited to ischemic CHF. © 2023, The Author(s).Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]