A Trophy of the First World War in the Air: Captain William Wendell Rogers and his Victory over a German Gotha Bomber, 12 December 1917

On 12 December 1917, Captain Wendell Rogers, a Canadian pilot in the Royal Flying Corps, was leading a patrol near Ypres, Belgium when his flight intercepted a group of German bombers. In the ensuing combat Rogers shot down a giant Gotha bomber, the first time such an aircraft had been brought down over continental Europe. A piece of that bomber was recovered and was recently acquired by the Canadian War Museum. The artifact, a fabric Iron Cross salvaged from the wing of the downed Gotha, was donated by Captain Rogers’ son Lloyd. The following article will trace how this object came to reside at the new Canadian War Museum in Ottawa

A Trophy of the First World War in the Air: Captain William Wendell Rogers and his Victory over a German Gotha Bomber, 12 December 1917

On 12 December 1917, Captain Wendell Rogers, a Canadian pilot in the Royal Flying Corps, was leading a patrol near Ypres, Belgium when his flight intercepted a group of German bombers. In the ensuing combat Rogers shot down a giant Gotha bomber, the first time such an aircraft had been brought down over continental Europe. A piece of that bomber was recovered and was recently acquired by the Canadian War Museum. The artifact, a fabric Iron Cross salvaged from the wing of the downed Gotha, was donated by Captain Rogers’ son Lloyd. The following article will trace how this object came to reside at the new Canadian War Museum in Ottawa

Candidate Effectors From Uromyces appendiculatus, the Causal Agent of Rust on Common Bean, Can Be Discriminated Based on Suppression of Immune Responses

Rust fungi are devastating pathogens for several important crop plants. The biotrophic lifestyle of rust fungi requires that they influence their host plants to create a favorable environment for growth and reproduction. Rust fungi secrete a variety of effector proteins that manipulate host target proteins to alter plant metabolism and suppress defense responses. Because of the obligate biotrophic lifestyle of rust fungi, direct evidence for effector function is difficult to obtain, and so suites of experiments utilizing expression in heterologous systems are necessary. Here, we present results from a yeast cell death suppression assay and assays for suppression of PAMP-triggered immunity (PTI) and effector triggered immunity (ETI) based on delivery of effectors through the bacterial type III secretion system. In addition, subcellular localization was tested using transient expression of GFP fusion proteins in Nicotiana benthamiana through Agrobacterium infiltration. We tested 31 representative effector candidates from the devastating common bean rust pathogen Uromyces appendiculatus. These effector candidates were selected based on features of their gene families, most important lineage specificity. We show that several of our effector candidates suppress plant defense. Some of them also belong to families of effector candidates that are present in multiple rust species where their homologs probably also have effector functions. In our analysis of candidate effector mRNA expression, some of those effector candidates that gave positive results in the other assays were not up-regulated during plant infection, indicating that either these proteins have functions at multiple life stages or that strong up-regulation of RNA level in planta may not be as important a criterion for identifying effectors as previously thought. Overall, our pipeline for selecting effector candidates based on sequence features followed by screening assays using heterologous expression systems was successful in discriminating effector candidates. This work lays the foundation for functional characterization of U. appendiculatus effectors, the identification of effector targets, and identification of novel sources for resistance in common bean

Suppression or Activation of Immune Responses by Predicted Secreted Proteins of the Soybean Rust Pathogen Phakopsora pachyrhizi

Rust fungi, such as the soybean rust pathogen Phakopsora pachyrhizi, are major threats to crop production. They form specialized haustoria that are hyphal structures intimately associated with host-plant cell membranes. These haustoria have roles in acquiring nutrients and secreting effector proteins that manipulate host immune systems. Functional characterization of effector proteins of rust fungi is important for understanding mechanisms that underlie their virulence and pathogenicity. Hundreds of candidate effector proteins have been predicted for rust pathogens, but it is not clear how to prioritize these effector candidates for further characterization. There is a need for high-throughput approaches for screening effector candidates to obtain experimental evidence for effector-like functions, such as the manipulation of host immune systems. We have focused on identifying effector candidates with immune-related functions in the soybean rust fungus P. pachyrhizi. To facilitate the screening of many P. pachyrhizi effector candidates (named PpECs), we used heterologous expression systems, including the bacterial type III secretion system, Agrobacterium infiltration, a plant virus, and a yeast strain, to establish an experimental pipeline for identifying PpECs with immune-related functions and establishing their subcellular localizations. Several PpECs were identified that could suppress or activate immune responses in nonhost Nicotiana benthamiana, N. tabacum, Arabidopsis, tomato, or pepper plants

Acoustic Energy and Momentum in a Moving Medium

By exploiting the mathematical analogy between the propagation of sound in a non-homogeneous potential flow and the propagation of a scalar field in a background gravitational field, various wave ``energy'' and wave ``momentum'' conservation laws are established in a systematic manner. In particular the acoustic energy conservation law due to Blokhintsev appears as the result of the conservation of a mixed co- and contravariant energy-momentum tensor, while the exchange of relative energy between the wave and the mean flow mediated by the radiation stress tensor, first noted by Longuet-Higgins and Stewart in the context of ocean waves, appears as the covariant conservation of the doubly contravariant form of the same energy-momentum tensor.Comment: 25 Pages, Late

On the breaking of a plasma wave in a thermal plasma: I. The structure of the density singularity

The structure of the singularity that is formed in a relativistically large amplitude plasma wave close to the wavebreaking limit is found by using a simple waterbag electron distribution function. The electron density distribution in the breaking wave has a typical "peakon" form. The maximum value of the electric field in a thermal breaking plasma is obtained and compared to the cold plasma limit. The results of computer simulations for different initial electron distribution functions are in agreement with the theoretical conclusions.Comment: 21 pages, 12 figure

Evaluating Student Volunteer and Service-Learning Programs: A Casebook for Practitioners

Today, evaluation concepts and methods are widely available to those who plan and administer student volunteer programs. Unfortunately, however, evaluation has all too often been carried out-and written about-in ways that have robbed it of its usefulness to people dealing with the realities of day-to-day program operation. Evaluation has thus acquired the reputation among practitioners of being too complex, too costly, too time-consuming, even too threatening to be of much practical value

Discrete breathers in honeycomb Fermi-Pasta-Ulam lattices

We consider the two-dimensional Fermi-Pasta-Ulam lattice with hexagonal honeycomb symmetry, which is a Hamiltonian system describing the evolution of a scalar-valued quantity subject to nearest neighbour interactions. Using multiple-scale analysis we reduce the governing lattice equations to a nonlinear Schrodinger (NLS) equation coupled to a second equation for an accompanying slow mode. Two cases in which the latter equation can be solved and so the system decoupled are considered in more detail: firstly, in the case of a symmetric potential, we derive the form of moving breathers. We find an ellipticity criterion for the wavenumbers of the carrier wave, together with asymptotic estimates for the breather energy. The minimum energy threshold depends on the wavenumber of the breather. We find that this threshold is locally maximised by stationary breathers. Secondly, for an asymmetric potential we find stationary breathers, which, even with a quadratic nonlinearity generate no second harmonic component in the breather. Plots of all our findings show clear hexagonal symmetry as we would expect from our lattice structure. Finally, we compare the properties of stationary breathers in the square, triangular and honeycomb lattices

Soliton Interactions in Perturbed Nonlinear Schroedinger Equations

We use multiscale perturbation theory in conjunction with the inverse scattering transform to study the interaction of a number of solitons of the cubic nonlinear Schroedinger equation under the influence of a small correction to the nonlinear potential. We assume that the solitons are all moving with the same velocity at the initial instant; this maximizes the effect each soliton has on the others as a consequence of the perturbation. Over the long time scales that we consider, the amplitudes of the solitons remain fixed, while their center of mass coordinates obey Newton's equations with a force law for which we present an integral formula. For the interaction of two solitons with a quintic perturbation term we present more details since symmetries -- one related to the form of the perturbation and one related to the small number of particles involved -- allow the problem to be reduced to a one-dimensional one with a single parameter, an effective mass. The main results include calculations of the binding energy and oscillation frequency of nearby solitons in the stable case when the perturbation is an attractive correction to the potential and of the asymptotic "ejection" velocity in the unstable case. Numerical experiments illustrate the accuracy of the perturbative calculations and indicate their range of validity.Comment: 28 pages, 7 figures, Submitted to Phys Rev E Revised: 21 pages, 6 figures, To appear in Phys Rev E (many displayed equations moved inline to shorten manuscript

アトガキ

Background: Bullous pemphigoid (BP) is an autoimmune blistering skin disorder associated with significant morbidity and mortality. Doxycycline and prednisolone to treat bullous pemphigoid were compared within a randomised controlled trial (RCT). Objectives: To compare the cost-effectiveness of doxycycline-initiated and prednisolone-initiated treatment for patients with BP. Methods: a multicentre, parallel-group, investigator-blinded RCT. Within-trial analysis used bivariate regression of costs and QALYs, with multiple imputation of missing data, informing a probabilistic assessment of incremental treatment cost-effectiveness from a health service perspective Results: In the base case, there was no robust difference in costs or QALYs per patient at 1 year comparing doxycycline-initiated therapy with prednisolone-initiated therapy (net cost: £959, 95% CI –£24 to £1941; net QALYs: –0.024, 95% CI –0.088 to 0.041). However, findings varied by baseline blister severity. For patients with mild or moderate blistering (≤30) net costs and outcomes were similar. For patients with severe blistering (>30) net costs were higher (£2558, 95% CI –£82 to £5198) and quality of life poorer (–0.090 QALYs, 95% CI–0.222 to 0.042) for patients starting on doxycycline. The probability that doxycycline would be cost-effective for those with severe pemphigoid was 1.5% at a willingness to pay of £20,000/QALY. Conclusions: Consistent with the clinical findings of the BLISTER trial, patients with mild or moderate blistering should receive treatment guided by the safety and effectiveness of the drugs and patient preference - neither strategy is clearly a preferred use of NHS resources. However, prednisolone-initiated treatment may be more cost-effective for patients with severe blistering