13,827 research outputs found
Multidimensional Simulations of Rotating Pair Instability Supernovae
We study the effects of rotation on the dynamics, energetics and Ni-56
production of Pair Instability Supernova explosions by performing rotating
two-dimensional ("2.5-D") hydrodynamics simulations. We calculate the evolution
of eight low metallicity (Z = 10^-3, 10^-4 Zsun) massive (135-245 Msun) PISN
progenitors with initial surface rotational velocities 50% that of the critical
Keplerian value using the stellar evolution code MESA. We allow for both the
inclusion and the omission of the effects of magnetic fields in the angular
momentum transport and in chemical mixing, resulting in slowly-rotating and
rapidly-rotating final carbon-oxygen cores, respectively. Increased rotation
for carbon-oxygen cores of the same mass and chemical stratification leads to
less energetic PISN explosions that produce smaller amounts of Ni-56 due to the
effect of the angular momentum barrier that develops and slows the dynamical
collapse. We find a non-monotonic dependence of Ni-56 production on rotational
velocity in situations when smoother composition gradients form at the outer
edge of the rotating cores. In these cases, the PISN energetics are determined
by the competition of two factors: the extent of chemical mixing in the outer
layers of the core due to the effects of rotation in the progenitor evolution
and the development of angular momentum support against collapse. Our 2.5-D
PISN simulations with rotation are the first presented in the literature. They
reveal hydrodynamic instabilities in several regions of the exploding star and
increased explosion asymmetries with higher core rotational velocity.Comment: 31 pages, 23 figures, accepted for publication in the Ap
Field Theory as Free Fall
It is shown that the classical field equations pertaining to gravity coupled
to other bosonic fields are equivalent to a single geodesic equation,
describing the free fall of a point particle in superspace. Some implications
for quantum gravity are discussed.Comment: 18 pages, plain late
Aversive Stimuli Drive Drug Seeking in a State of Low Dopamine Tone
Background Stressors negatively impact emotional state and drive drug seeking, in part, by modulating the activity of the mesolimbic dopamine system. Unfortunately, the rapid regulation of dopamine signaling by the aversive stimuli that cause drug seeking is not well characterized. In a series of experiments, we scrutinized the subsecond regulation of dopamine signaling by the aversive stimulus, quinine, and tested its ability to cause cocaine seeking. Additionally, we examined the midbrain regulation of both dopamine signaling and cocaine seeking by the stress-sensitive peptide, corticotropin releasing factor (CRF). Methods Combining fast-scan cyclic voltammetry with behavioral pharmacology, we examined the effect of intraoral quinine administration on nucleus accumbens dopamine signaling and hedonic expression in 21 male Sprague-Dawley rats. We tested the role of CRF in modulating aversion-induced changes in dopamine concentration and cocaine seeking by bilaterally infusing the CRF antagonist, CP-376395, into the ventral tegmental area (VTA). Results We found that quinine rapidly reduced dopamine signaling on two distinct time scales. We determined that CRF acted in the VTA to mediate this reduction on only one of these time scales. Further, we found that the reduction of dopamine tone and quinine-induced cocaine seeking were eliminated by blocking the actions of CRF in the VTA during the experience of the aversive stimulus. Conclusions These data demonstrate that stress-induced drug seeking can occur in a terminal environment of low dopamine tone that is dependent on a CRF-induced decrease in midbrain dopamine activity
Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury
Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD
Yang-Mills gravity in biconformal space
We write a gravity theory with Yang-Mills type action using the biconformal
gauging of the conformal group. We show that the resulting biconformal
Yang-Mills gravity theories describe 4-dim, scale-invariant general relativity
in the case of slowly changing fields. In addition, we systematically extend
arbitrary 4-dim Yang-Mills theories to biconformal space, providing a new arena
for studying flat space Yang-Mills theories. By applying the biconformal
extension to a 4-dim pure Yang-Mills theory with conformal symmetry, we
establish a 1-1, onto mapping between a set of gravitational gauge theories and
4-dim, flat space gauge theories.Comment: 27 pages; paper emphasis shifted to focus on gravity; references
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Phase field modeling of electrochemistry II: Kinetics
The kinetic behavior of a phase field model of electrochemistry is explored
for advancing (electrodeposition) and receding (electrodissolution) conditions
in one dimension. We described the equilibrium behavior of this model in [J. E.
Guyer, W. J. Boettinger, J.A. Warren, and G. B. McFadden, ``Phase field
modeling of electrochemistry I: Equilibrium'', cond-mat/0308173]. We examine
the relationship between the parameters of the phase field method and the more
typical parameters of electrochemistry. We demonstrate ohmic conduction in the
electrode and ionic conduction in the electrolyte. We find that, despite making
simple, linear dynamic postulates, we obtain the nonlinear relationship between
current and overpotential predicted by the classical ``Butler-Volmer'' equation
and observed in electrochemical experiments. The charge distribution in the
interfacial double layer changes with the passage of current and, at
sufficiently high currents, we find that the diffusion limited deposition of a
more noble cation leads to alloy deposition with less noble species.Comment: v3: To be published in Phys. Rev. E v2: Attempt to work around
turnpage bug. Replaced color Fig. 4a with grayscale 13 pages, 7 figures in 10
files, REVTeX 4, SIunits.sty, follows cond-mat/030817
Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts
Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 mediated cytokine activation. The aim of this study was to investigate factors associated with LPS in dogs with CPSS. Plasma LPS concentrations were measured in the peripheral and portal blood using a limulus amoebocyte lysate (LAL) assay.
LPS concentration was significantly greater in the portal blood compared to peripheral blood in dogs with CPSS (P = 0.046) and control dogs (P = 0.002). LPS concentrations in the peripheral (P = 0.012) and portal (P = 0.005) blood of dogs with CPSS were significantly greater than those of control dogs. The relative mRNA expression of cytokines and TLRs was measured in liver biopsies from dogs with CPSS using quantitative PCR. TLR4 expression significantly increased following partial CPSS attenuation (P = 0.020). TLR4 expression was significantly greater in dogs that tolerated complete CPSS attenuation (P = 0.011) and those with good portal blood flow on pre-attenuation (P = 0.004) and post-attenuation (P = 0.015) portovenography. Serum interleukin (IL)-6 concentration was measured using a canine specific ELISA and significantly increased 24 h following CPSS attenuation (P < 0.001). Portal LPS was increased in dogs with CPSS, consistent with decreased hepatic clearance. TLR4 mRNA expression was significantly associated with portal blood flow and increased following surgery. These findings support the concept that portal LPS delivery is important in the hepatic response to surgical attenuation. Serum IL-6 significantly increased following surgery, consistent with LPS stimulation via TLR4, although this increase might be non-specific
Information-theoretic principle entails orthomodularity of a lattice
Quantum logical axiomatic systems for quantum theory usually include a
postulate that a lattice under consideration is orthomodular. We propose a
derivation of orthomodularity from an information-theoretic axiom. This
provides conceptual clarity and removes a long-standing puzzle about the
meaning of orthomodularity.Comment: Version prior to published, with slight modification
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