The Effect of Relational Aggression Training on New Emergency Department Nurses

BACKGROUND: Relational aggression (RA) in nursing is widespread. One group often at risk for exposure to RA is the newly licensed nurse. RA can lead to a negative work environment which can cause poor patient outcomes and high nurse turnover. PURPOSE: The purpose of this study was to evaluate the effects of an educational program on RA in the emergency department with newly licensed registered nurses. This was conducted using one pre and two post surveys. The surveys evaluated the nurses’ knowledge of RA self-awareness before and six weeks after an educational session. METHODS: This was a single-site, single-unit pretest posttest study including 12 nurses working in the University of Kentucky Emergency Department. The educational program included didactic interactive subject interaction guided by prepared scenarios. The participants received written materials for future use following the formal education. The study was conducted December 2021-January 2022 after IRB approval. RESULTS: Overall, no statistically significant change in the NAQ-R was found but there was a statistically significant change in the person-related questions (p = 0.05). There was also a statistically significant increase in perceived understanding of relational aggression (p = 0.10), DISCUSSION: Due to the sample size and survey response, the results of this study are limited. Although the changes were small, there was an increase in most areas from the pre-survey to the post-survey. CONCLUSION: It is recommended that this study be repeated with a larger group. If the results are statistically significant, it could be expanded within the enterprise and beyon

Readability of newspapers in Arkansas compared to regional papers around the nation

Newspaper readability plays an important role in how well people perceive and understand the paper. A text’s reading level is one of the main contributors to the document’s readability, so testing articles’ reading level is a way to gauge how a newspaper is serving an area. Newspaper reading levels are also a reflection of the community. Historically, Arkansas has had low reading and literacy levels. Using an average of five readability calculators, this study tests the readability of Arkansas newspapers in comparison to reading levels of newspapers around the nation. Arkansas newspapers averaged nearly a full reading level lower than the other papers, showing that Arkansas still has room for improvement to become competitive nationally. Newspapers face a lot of competition from other types of media, so testing readability is an excellent tool for editors to strike a balance between informing and educating their readers, ensuring appeal and comprehension

The Ergogenic Effects of Acute Citrulline Malate Supplementation on Weightlifting Performance in Trained Females

All previous investigations evaluating the effectiveness of citrulline malate (CM) as an ergogenic aid involved male subjects. The purpose of this investigation was to evaluate the ergogenic effects of CM supplementation on upper- and lower-body, submaximal, resistance exercise performance in trained females. Based on previous results, we hypothesized supplementation with CM would increase performance in females. This study utilized a randomized, double blind, crossover design. Testing trials took place within the Human Performance Laboratory and/or the University of Arkansas: Donna Axum Fitness Center. An a priori sample of 14 subjects were required, therefore this study included 15 female. Subjects reported for three visits. Visit one included demographic/body composition, and one-repetition maximum (1-RM) measurements. On subsequent visits, subjects consumed CM (8 g dextrose+8 g CM) or placebo (8 g dextrose) prior to beginning exercise. The protocol included: six sets of upper-body exercise and six sets of lower-body exercise at 80% 1-RM with one minute rest between each upper- and lower-body set and two minutes rest when transitioning from upper- to lower-body exercises. Repeated measures ANOVA determined trial differences. Paired-tests evaluated differences between total repetitions, initial and final halves, and the initial, middle, and final thirds of each exercise between trials. During the final half of upper-body exercise, subjects completed significantly (p = .04) more repetitions when consuming CM (12.13±2.85) compared to placebo (11.13±2.75). Similar results were observed during lower-body exercise. Total repetitions (66.73±30.49 vs. 55.13±20.64, p = .03), repetitions completed during the middle third (18.36±6.71 vs. 15.29±5.78, p = .05), final third (17.57±7.19 vs. 14.21±7.15, p = .02), and final half (26.50±10.70 vs. 21.71±9.76, p = .04) of exercise were significantly greater for CM compared to placebo, respectively. In trained females, CM supplementation increased performance during submaximal resistance exercise. These data have attractive implications for female athletes competing in sports with strength-based requirements. Keywords: ergogenic aids, Citrulline malate, nitric oxide, and exercise performance in females, strength training, and all related derivatives

Expression Validation of miR-149-5p targets in prostate cancer

Prostate cancer (PCa) is one of the leading causes of mortality in men. Current therapeutics for PCa are androgen depletion by castration or/and anti-androgen based treatments. Androgens are necessary for Androgen receptor (AR) to function as a transcription factor, AR then regulates the expression of genes which promote cancer cell proliferation. However, despite the therapeutic interventions recurred AR signaling, which is facilitated by the acquisition of mutations in AR and its amplification, cholesterol biosynthesis and alterations in the steroidogenesis continue promoting PCa carcinogenesis. Our research is focused on regulatory small RNA molecules know as microRNAs (miRNA) in PCa. Numerous miRNAs fine-tune the expression of multiple genes involved in posttranslational modification, cell proliferation, organogenesis, energy balancing and developmental regulation thus affecting cell proliferation, differentiation, and cell death. miRNA “replacement therapy” is highly promising as it can target the expression of carcinogenesis promoting AR and androgen signaling, the holy grail of PCa therapeutics. In this research project, we have tested the efficiency of miR-149-5p in controlling AR expression using a sensor luciferase reporter assay system in PCa cell culture model. We found a significant downregulation of AR reporter gene in PCa cells indicating the efficacy of miR-149-5p in controlling the growth of AR based tumors. Our result indicates miRNA mediated regulation of genes involved in PCa and therapeutic potential.https://engagedscholarship.csuohio.edu/u_poster_2017/1014/thumbnail.jp

Expression Validation of miR-149-5p targets in prostate cancer

Prostate cancer (PCa) is one of the leading causes of mortality in men. Current therapeutics for PCa are androgen depletion by castration or/and anti-androgen based treatments. Androgens are necessary for Androgen receptor (AR) to function as a transcription factor, AR then regulates the expression of genes which promote cancer cell proliferation. However, despite the therapeutic interventions recurred AR signaling, which is facilitated by the acquisition of mutations in AR and its amplification, cholesterol biosynthesis and alterations in the steroidogenesis continue promoting PCa carcinogenesis. Our research is focused on regulatory small RNA molecules know as microRNAs (miRNA) in PCa. Numerous miRNAs fine-tune the expression of multiple genes involved in posttranslational modification, cell proliferation, organogenesis, energy balancing and developmental regulation thus affecting cell proliferation, differentiation, and cell death. miRNA “replacement therapy” is highly promising as it can target the expression of carcinogenesis promoting AR and androgen signaling, the holy grail of PCa therapeutics. In this research project, we have tested the efficiency of miR-149-5p in controlling AR expression using a sensor luciferase reporter assay system in PCa cell culture model. We found a significant downregulation of AR reporter gene in PCa cells indicating the efficacy of miR-149-5p in controlling the growth of AR based tumors. Our result indicates miRNA mediated regulation of genes involved in PCa and therapeutic potential.https://engagedscholarship.csuohio.edu/u_poster_2017/1014/thumbnail.jp