The Public Papers of Governor Lawrence W. Wetherby, 1950-1955

This volume preserves the public papers and letters from the five-year period when Lawrence W. Wetherby was governor of the Commonwealth of Kentucky. Relatively little of this material has been available heretofore to the general public. And its inaccessibility may explain why the Wetherby administration has yet to be fully appreciated even by historians and political scientists. The years 1950 through 1955 offered problems and opportunities that made being governor both a challenge and a joy. It was a period of economic growth fostered by the artificial stimulus of the Korean War, and sudden economic readjustment when the war ended, that resulted in financial problems for Kentucky’s government. There was depression in the important coal industry that caused a mass exodus of people from eastern Kentucky. A brief drought impaired agricultural production. While President Harry Truman had been quite solicitous of the state’s needs, the new Republican administration in Washington was less so. Yet, of a positive nature, there was an influx of tourists, a concerted effort to diversify the state’s economic base through industrialization, and an attempt to mitigate a characteristic isolation both within and without through the construction of toll roads and rural highways. The papers in this volume reflect the thought of Kentucky’s executive branch on all of these issues. John E. Kleber is professor emeritus of history at Morehead State University. He has served as director of the Academic Honors Program (1973-1988) and interim dean of the Caudill College of Humanities (1993-1995). Kleber received both the Outstanding Teacher (1982) and Distinguished Researcher (1993) Awards from Morehead State. He was given the Outstanding Service Medal by the United States Army (1971), the Governor\u27s Outstanding Kentuckian Award (1992), and the Catholic Alumni Award by the Archdiocese of Louisville (2002). He is the editor of six books, including The Kentucky Encyclopedia, A Home for Children: A History of Brooklawn, and Thomas D. Clark of Kentucky: An Uncommon Life in the Commonwealth.https://uknowledge.uky.edu/upk_political_science_papers/1007/thumbnail.jp

Comparative analyses of multi-species sequences from targeted genomic regions

The systematic comparison of genomic sequences from different organisms represents a central focus of contemporary genome analysis. Comparative analyses of vertebrate sequences can identify coding and conserved non-coding regions, including regulatory elements, and provide insight into the forces that have rendered modern-day genomes. As a complement to whole-genome sequencing efforts, we are sequencing and comparing targeted genomic regions in multiple, evolutionarily diverse vertebrates. Here we report the generation and analysis of over 12 megabases (Mb) of sequence from 12 species, all derived from the genomic region orthologous to a segment of about 1.8 Mb on human chromosome 7 containing ten genes, including the gene mutated in cystic fibrosis. These sequences show conservation reflecting both functional constraints and the neutral mutational events that shaped this genomic region. In particular, we identify substantial numbers of conserved non-coding segments beyond those previously identified experimentally, most of which are not detectable by pair-wise sequence comparisons alone. Analysis of transposable element insertions highlights the variation in genome dynamics among these species and confirms the placement of rodents as a sister group to the primates