Modeling of oligomeric-state dependent spectral heterogeneity in the B875 light-harvesting complex of Rhodobacter sphaeroides by numerical simulation

A series of detergent-isolated light-harvesting 1 (LH1, B875) complexes from Rhodobacter sphaeroides, estimated to range in size from (RâBChl2)4 to (RâBChl2)13, was used to study the combined effects of spectral disorder and excitonic interactions on oligomeric-state dependent optical properties. Numerical simulations of absorption and fluorescence emission, excitation, and polarization spectra, based on the structure of the related LH2 complex, were compared to spectra measured experimentally at 77 K (Westerhuis and Niederman, in preparation). The aggregation-state dependence of the polarization spectra was found to be particularly sensitive to the choice of parameters, and vibronic components were included to obtain satisfactory simulations. Good agreement with most experimental features, including the oligomeric-state dependence of the absorption and emission maxima, was obtained only when the inter- and intradimer coupling strengths for adjacent BChls were similar (200-260 cm-1), and the width for the inhomogeneous distribution function (300-400 cm-1) was comparable. The relevance of these findings to existing controversies on the physical origin of spectral heterogeneity observed for the LH1 complex is discussed

Co-creation of an online portal for dialysis patients with low eHealth literacy : effect on adoption

IntroductionThe use of information and communication technology in health care, also called eHealth, is an important strategy to create sustainable health care organizations. EHealth can support patients’ self-management, for example with patient portals or smart technology to monitor health. Improved self-management can abate the growing care demand, caused by an ageing population.Patients with low eHealth literacy (LeHL) miss competences to seek, find, understand and appraise health information from electronic resources. They are less equipped to adopt eHealth. To overcome disadvantages, it is important to develop interventions that improve access to and use of eHealth for this group of patients. Co-creation with patients is important to tailor interventions to their needs.This study focuses on dialysis patients with LeHL. Self-management is a major, but challenging component of their treatment. EHealth can support self-management, but low Internet use in patients with kidney disease may limit effectiveness. Less than 1% of existing self-management interventions is co-created, which also seems to reduce effectiveness. This research aims to 1) explore the eHealth experiences, needs and barriers of dialysis patients with LeHL, 2) discuss eHealth support strategies for this group with health care professionals and 3) assess the impact of co-designed interventions on eHealth adoption and usability.MethodsTo explore eHealth experiences, needs and barriers (Aim 1), we performed two focus group discussions (FGD) (N=3) and in-depth interviews (N=4) with patients with LeHL from two dialysis centers in the Northeastern part of the Netherlands. We assessed eHealth literacy with the eHeals questionnaire. We transcribed and analyzed the data, using the Technology Acceptance Model. The major themes were the starting point for the development of an eHealth intervention. To discuss eHealth support strategies (Aim 2), we consulted the multidisciplinary team during interviews (N=5) and a workgroup meeting (N=6). We discussed the LeHL patients’ experiences, needs and barriers and brainstormed about support strategies. The professionals’ input led to the design and content of the first prototype of the eHealth intervention.To analyze the impact of co-designed interventions (Aim 3) we tested three prototypes, following the principles of design thinking. We tested in four dialysis centers in the same region with 6-8 weeks in-between (N=40). Each prototype was tested by a control group with high (N=7-12) and target group with low (N=6-8) eHealth literacy. Patients were classified as LeHL by asking them about computer use and with a shortened form of the eHeals. Some participants tested all prototypes to reflect on improvements. Half of the approached re-testers with LeHL (N=4) were lost at follow-up. They were not motivated for a second test. All groups navigated the prototypes, following a scenario. A computer program measured navigation behavior. Talking-out-loud was used to assess perceived usability and satisfaction. An eHealth adoption questionnaire was used to validate results. Analyzed data were used to re-design each following prototype.Results Characteristics LeHL patients had a mean age of 70 and all followed low or middle education. They visited in center dialysis three times a week. The health care professionals were a good representation of the multidisciplinary team. eHealth experiences, needs and barriersMain barriers for eHealth adoption were a lack of computer knowledge, skills and experience. Participants also reported resistance against digitalization, because they believe it reduces personal contact and impacts quality of life, for example when shops close. Fear for privacy issues and errors played a role in the intention to adopt eHealth. High-frequent contact with professionals further diminishes the need for eHealth. Patients reported that an easy design and support of others are important facilitators. Main content needs are information on lab values, diet and medication.Finding an eHealth strategyProfessionals validated the suggested content by the patients. They suggested an easy-to-use prototype patient portal, with a personal patient story and realistic medical information, to support patients with LeHL. During use, patients should get hints and rewards to heighten entertainment. Co-development and analysisPatients with LeHL believed the content of the first prototype was useful, but too difficult. The computer program showed that patients lack basal skills to navigate. They struggled to open videos and read written content due to language barriers or impatience. The questionnaires showed a trend that patients with LeHL were more negative about their skills and knowledge after use. In the second prototype information was simplified and personalized. The design was enriched with colors and symbols. LeHL patients showed improved navigation and expressed higher satisfaction with the design and comprehensibility, especially of the lab values. Questionnaires showed that participants were, after use, more positive about usefulness and their competences. Although, LeHL patients were not always convinced about the need to use eHealth in the future. The analyzed results of the third prototype are expected in one month.Conclusions and discussionMany dialysis patients are low eHealth literate. They miss competences to adopt eHealth and have negative thoughts about digitalization. If possible, they prefer face-to-face support. Co-creation helps to develop comprehensible and easy-to use eHealth solutions for patients with LeHL, which can increase belief in personal competences. Health care organizations should improve support of patients with LeHL in an evolving digital world. Developers should improve the usability of patient portals, since this can facilitate eHealth adoption by empowering the patients’ belief in personal competences. Face-to-face contact offers another possible strategy. When professionals succeed to explain benefits and incorporate eHealth in consultations, patients are more willing to use it. Organizations should also reach out to the patients’ relatives, since they often support Internet use. This research also indicates the importance of co-creation. The first prototype led to a negative experience and a reduced belief in personal competences. The loss-to-follow-up in the group with LeHL illustrates that non-tailored eHealth solutions can cause a direct loss of users. Co-creation and the relation to adoption needs further research and implementation in eHealth development.<br/

Co-creation of an online portal for dialysis patients with low eHealth literacy : effect on adoption

IntroductionThe use of information and communication technology in health care, also called eHealth, is an important strategy to create sustainable health care organizations. EHealth can support patients’ self-management, for example with patient portals or smart technology to monitor health. Improved self-management can abate the growing care demand, caused by an ageing population.Patients with low eHealth literacy (LeHL) miss competences to seek, find, understand and appraise health information from electronic resources. They are less equipped to adopt eHealth. To overcome disadvantages, it is important to develop interventions that improve access to and use of eHealth for this group of patients. Co-creation with patients is important to tailor interventions to their needs.This study focuses on dialysis patients with LeHL. Self-management is a major, but challenging component of their treatment. EHealth can support self-management, but low Internet use in patients with kidney disease may limit effectiveness. Less than 1% of existing self-management interventions is co-created, which also seems to reduce effectiveness. This research aims to 1) explore the eHealth experiences, needs and barriers of dialysis patients with LeHL, 2) discuss eHealth support strategies for this group with health care professionals and 3) assess the impact of co-designed interventions on eHealth adoption and usability.MethodsTo explore eHealth experiences, needs and barriers (Aim 1), we performed two focus group discussions (FGD) (N=3) and in-depth interviews (N=4) with patients with LeHL from two dialysis centers in the Northeastern part of the Netherlands. We assessed eHealth literacy with the eHeals questionnaire. We transcribed and analyzed the data, using the Technology Acceptance Model. The major themes were the starting point for the development of an eHealth intervention. To discuss eHealth support strategies (Aim 2), we consulted the multidisciplinary team during interviews (N=5) and a workgroup meeting (N=6). We discussed the LeHL patients’ experiences, needs and barriers and brainstormed about support strategies. The professionals’ input led to the design and content of the first prototype of the eHealth intervention.To analyze the impact of co-designed interventions (Aim 3) we tested three prototypes, following the principles of design thinking. We tested in four dialysis centers in the same region with 6-8 weeks in-between (N=40). Each prototype was tested by a control group with high (N=7-12) and target group with low (N=6-8) eHealth literacy. Patients were classified as LeHL by asking them about computer use and with a shortened form of the eHeals. Some participants tested all prototypes to reflect on improvements. Half of the approached re-testers with LeHL (N=4) were lost at follow-up. They were not motivated for a second test. All groups navigated the prototypes, following a scenario. A computer program measured navigation behavior. Talking-out-loud was used to assess perceived usability and satisfaction. An eHealth adoption questionnaire was used to validate results. Analyzed data were used to re-design each following prototype.Results Characteristics LeHL patients had a mean age of 70 and all followed low or middle education. They visited in center dialysis three times a week. The health care professionals were a good representation of the multidisciplinary team. eHealth experiences, needs and barriersMain barriers for eHealth adoption were a lack of computer knowledge, skills and experience. Participants also reported resistance against digitalization, because they believe it reduces personal contact and impacts quality of life, for example when shops close. Fear for privacy issues and errors played a role in the intention to adopt eHealth. High-frequent contact with professionals further diminishes the need for eHealth. Patients reported that an easy design and support of others are important facilitators. Main content needs are information on lab values, diet and medication.Finding an eHealth strategyProfessionals validated the suggested content by the patients. They suggested an easy-to-use prototype patient portal, with a personal patient story and realistic medical information, to support patients with LeHL. During use, patients should get hints and rewards to heighten entertainment. Co-development and analysisPatients with LeHL believed the content of the first prototype was useful, but too difficult. The computer program showed that patients lack basal skills to navigate. They struggled to open videos and read written content due to language barriers or impatience. The questionnaires showed a trend that patients with LeHL were more negative about their skills and knowledge after use. In the second prototype information was simplified and personalized. The design was enriched with colors and symbols. LeHL patients showed improved navigation and expressed higher satisfaction with the design and comprehensibility, especially of the lab values. Questionnaires showed that participants were, after use, more positive about usefulness and their competences. Although, LeHL patients were not always convinced about the need to use eHealth in the future. The analyzed results of the third prototype are expected in one month.Conclusions and discussionMany dialysis patients are low eHealth literate. They miss competences to adopt eHealth and have negative thoughts about digitalization. If possible, they prefer face-to-face support. Co-creation helps to develop comprehensible and easy-to use eHealth solutions for patients with LeHL, which can increase belief in personal competences. Health care organizations should improve support of patients with LeHL in an evolving digital world. Developers should improve the usability of patient portals, since this can facilitate eHealth adoption by empowering the patients’ belief in personal competences. Face-to-face contact offers another possible strategy. When professionals succeed to explain benefits and incorporate eHealth in consultations, patients are more willing to use it. Organizations should also reach out to the patients’ relatives, since they often support Internet use. This research also indicates the importance of co-creation. The first prototype led to a negative experience and a reduced belief in personal competences. The loss-to-follow-up in the group with LeHL illustrates that non-tailored eHealth solutions can cause a direct loss of users. Co-creation and the relation to adoption needs further research and implementation in eHealth development.<br/

Modern Russian informational technologies of enterprise management. Platform 1C

The history of the development of the 1C program is briefly described. The topic of licensing and product safety was touched upon. Little is said about the corporate line and the new direction of 1C: EnterpriseDevelopmentTools. Also get acquainted with the products of 1C:ManufacturingEnterpriseManagement and 1C:EnterpriseResourcesPlanning

Vasopressin release is enhanced by the Hemocontrol biofeedback system and could contribute to better haemodynamic stability during haemodialysis

Haemodialysis with the Hemocontrol biofeedback system (HHD) is associated with improved haemodynamic stability compared with standard haemodialysis (HD) (SHD). Although the beneficial effect of HHD on haemodynamic stability is generally explained by its effect on blood volume, we questioned whether additional factors could play a role. Since HHD is associated with higher initial dialysate sodium concentrations and ultrafiltration (UF) rate, we studied whether the beneficial effect of HHD on haemodynamic stability may be explained by an increased release of the vasoconstrictor arginine vasopressin (AVP). Fifteen chronic dialysis patients underwent SHD and HHD in random order. All other treatment factors were identical and patients served as their own control. Plasma levels of AVP were measured pre-dialysis, at 30 and 60 min intra-dialysis and, next, hourly until completion of the dialysis session. Plasma AVP levels did not change significantly during SHD, whereas AVP levels rose significantly within 30 min after the start of HHD (P 0.01). AVP levels were significantly higher at 30 and 60 min of HHD in comparison with SHD (P 0.05). Dialysis hypotension occurred significantly less frequent during HHD than during SHD (P 0.05). HHD is associated with higher initial AVP levels compared with SHD. The enhanced release of the vasoconstrictor AVP with HHD could contribute to the lower frequency of dialysis hypotension by facilitating fluid removal during the first part of the dialysis session, permitting lower UF rates during the second half of the dialysis session

Strategic responses to global challenges: The case of European banking, 1973–2000

In applying a strategy, structure, ownership and performance (SSOP) framework to three major clearing banks (ABN AMRO, UBS, Barclays), this article debates whether the conclusions generated by Whittington and Mayer about European manufacturing industry can be applied to the financial services sector. While European integration plays a key role in determining strategy, it is clear that global factors were far more important in determining management actions, leading to significant differences in structural adaptation. The article also debates whether this has led to improved performance, given the problems experienced with both geographical dispersion and diversification, bringing into question the quality of decision-making over the long term