The presence of tranquil sounds in relation to augmented focus and concentration

The purpose of this investigation was to determine if the presence of tranquil sounds created augmented focus and concentration among undergraduate college students, who prefer silent learning environments. Participants were randomly selected from an undergraduate pool of students from a northeastern college in the United States. Student\u27s focus and concentration was assessed using the Personal Emotion Survey and Personal Habits Survey. The Mann-Whitney test was used to compare the scores of those who prefer silent or prefer sounds in the environment to their scores on the Personal Emotional Survey. As we have found from past studies, music plays an important role in emotions, verbal abilities and educational benefits for disabled individuals. Since research is limited in the area of focus and concentration, the present study used implications from previous research to fill the gaps in past research. The results showed statistical significance within group four, in which participants who preferred sounds indicated feeling more focused while in the silent group

Immobilization of Cell-Adhesive Laminin Peptides in Degradable PEGDA Hydrogels Influences Endothelial Cell Tubulogenesis

Attachment, spreading, and organization of endothelial cells into tubule networks are mediated by interactions between cells in the extracellular microenvironment. Laminins are key extracellular matrix components and regulators of cell adhesion, migration, and proliferation. In this study, laminin-derived peptides were conjugated to poly(ethylene glycol) (PEG) monoacrylate and covalently incorporated into degradable PEG diacrylate (PEGDA) hydrogels to investigate the influence of these peptides on endothelial cellular adhesion and function in organizing into tubule networks. Degradable PEGDA hydrogels were synthesized by incorporating a matrix metalloproteinase (MMP)-sensitive peptide, GGGPQGIWGQGK (abbreviated PQ), into the polymer backbone. The secretion ofMMP-2 and MMP-9 by endothelial cells promotes polymer degradation and consequently cell migration. We demonstrate the formation of extensive networks of tubule-like structures by encapsulated human umbilical vein endothelial cells in hydrogels with immobilized synthetic peptides. The resulting structures were stabilized by pericyte precursor cells (10T1/2s) in vitro. During tubule formation and stabilization, extracellular matrix proteins such as collagen IV and laminin were deposited. Tubules formed in the matrix of metalloproteinase sensitive hydrogels were visualized from 7 days to 4 weeks in response to different combination of peptides. Moreover, hydrogels functionalized with laminin peptides and transplanted in a mouse cornea supported the ingrowth and attachment of endothelial cells to the hydrogel during angiogenesis. Results of this study illustrate the use of laminin-derived peptides as potential candidates for modification of biomaterials to support angiogenesis

Can a Multi-Student Research Project Deliver a High Quality Learning Experience at Masters Level?

No abstract available

The Fragmenting Superbubble Associated with the HII Region W4

New observations at high latitudes above the HII region W4 show that the structure formerly identified as a chimney candidate, an opening to the Galactic halo, is instead a superbubble in the process of fragmenting and possibly evolving into a chimney. Data at high Galactic latitudes (b > 5 degrees) above the W3/W4 star forming region at 1420 and 408 MHz Stokes I (total power) and 1420 MHz Stokes Q and U (linear polarization) reveal an egg-shaped structure with morphological correlations between our data and the H-alpha data of Dennison, Topasna, & Simonetti. Polarized intensity images show depolarization extending from W4 up the walls of the superbubble, providing strong evidence that the radio continuum is generated by thermal emission coincident with the H-alpha emission regions. We conclude that the parts of the HII region hitherto known as W4 and the newly revealed thermal emission are all ionized by the open cluster OCl 352. Assuming a distance of 2.35 kpc, the ovoid structure is 164 pc wide and extends 246 pc above the mid-plane of the Galaxy. The shell's emission decreases in total-intensity and polarized intensity in various locations, appearing to have a break at its top and another on one side. Using a geometric analysis of the depolarization in the shell's walls, we estimate that a magnetic field line-of-sight component of 3 to 5 uG exists in the shell. We explore the connection between W4 and the Galactic halo, considering whether sufficient radiation can escape from the fragmenting superbubble to ionize the kpc-scale H-alpha loop discovered by Reynolds, Sterling & Haffner.Comment: 42 pages, 14 figures; Accepted for publication in Ap

Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs

Autologous bone grafting is the most effective treatment for long-bone nonunions, but it poses considerable risks to donors, necessitating the development of alternative therapeutics. Poly(ethylene glycol) (PEG) microencapsulation and BMP2 transgene delivery are being developed together to induce rapid bone formation. However, methods to make these treatments available for clinical applications are presently lacking. In this study we used mesenchymal stem cells (MSCs) due to their ease of harvest, replication potential, and immunomodulatory capabilities. MSCs were from sheep and pig due to their appeal as large animal models for bone nonunion. We demonstrated that cryopreservation of these microencapsulated MSCs did not affect their cell viability, adenoviral BMP2 production, or ability to initiate bone formation. Additionally, microspheres showed no appreciable damage from cryopreservation when examined with light and electron microscopy. These results validate the use of cryopreservation in preserving the viability and functionality of PEG-encapsulated BMP2-transduced MSCs

Methods for modifying cell contact with a surface

Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.Board of Regents, University of Texas Syste

The Past, Present, and Future of Research on Interviewer Effects

Interviewer-administered surveys are a primary method of collecting information from populations across the United States and the world. Various types of interviewer-administered surveys exist, including large-scale government surveys that monitor populations (e.g., the Current Population Survey), surveys used by the academic community to understand what people think and do (e.g., the General Social Survey), and surveys designed to gauge public opinion at a particular time point (e.g., the Gallup Daily Tracking Poll). Interviewers participate in these data collection efforts in a multitude of ways, including creating lists of housing units for sampling, persuading sampled units to participate, and administering survey questions (Morton-Williams 1993). In an increasing number of surveys, interviewers are also tasked with collecting blood, saliva, and other biomeasures, and asking survey respondents for consent to link survey data to administrative records (Sakshaug 2013). Interviewers are also used in mixed mode surveys to recruit and interview non respondents after less expensive modes like mail and web have failed (e.g., the American Community Survey and the Agricultural Resource Management Survey; de Leeuw 2005; Dillman, Smyth and Christian 2014; Olson et al. 2019). In completing these varied tasks, interviewers affect survey costs and coverage, nonresponse, measurement, and processing errors (Schaeffer, Dykema and Maynard 2010; West and Blom 2017)

Offer and Use of Smoking-Cessation Support by Depression/Anxiety Status: A Cross-Sectional Survey

INTRODUCTION: Higher levels of anxiety and depression have been found to be associated with greater difficulty in stopping smoking. This raises the question as to whether mood disturbance may be associated with exposure to, and use of, quitting support. AIMS: This study examined whether General Practitioner (GP) advice and/or offer of support, or stop-smoking service use differed between smokers reporting or not reporting depression/anxiety. METHODS: Data came from the Smoking Toolkit Study. Participants were 1,162 English adults who reported currently smoking or having stopped within the past 12 months, aged 40+ years, surveyed between April and September 2012. Anxiety/depression was assessed by the mood disturbance item of the EuroQol five dimensions questionnaire (EQ-5D). This was compared to recall of GP quit advice and/or support, and stop-smoking aid use adjusting for age, gender, and social grade. RESULTS/FINDINGS: Smokers reporting depression/anxiety were more likely to recall being offered advice and support to stop smoking by their GP (OR = 1.50, 95% C.I. = 1.05–2.13). However, there were no significant differences in use of stop-smoking aids during the past year. CONCLUSIONS: Smokers reporting depression/anxiety are more likely to be offered stop-smoking support by their GPs, but this does not appear to translate into stop-smoking aid use, despite high motivation to quit. Given higher nicotine dependence in this group, mental health specific support may need to be offered, and more needs to be done to make this offer of aid attractive