744 research outputs found
Posterior mean identifies the prior distribution in NB and related models
Bayes negative binomial models under two different parameterizations are shown to be completely identifable by the form of the Bayes estimates of the parameter. Also power series mixtures are briefly treated
On Abelian Multi-Chern-Simons Field Theories
In this paper a class of multi-Chern-Simons field theories which is relevant
to the statistical mechanics of polymer systems is investigated. Motivated by
the problems which one encounters in the treatment of these theories, a general
procedure is presented to eliminate the Chern-Simons fields from their action.
In this way it has been possible to derive an expression of the partition
function of topologically linked polymers which depends explicitly on the
topological numbers and does not have intractable nonlocal terms as it happened
in previous approaches. The new formulation of multi-Chern-Simons field
theories is then used to remove and clarify some inconsistencies and
ambiguities which apparently affect field theoretical models of topologically
linked polymers. Finally, the limit of disentangled polymers is discussed.Comment: 18 pages, plain LaTe
Density-functional embedding using a plane-wave basis
The constrained electron density method of embedding a Kohn-Sham system in a
substrate system (first described by P. Cortona, Phys. Rev. B {\bf 44}, 8454
(1991) and T.A. Wesolowski and A. Warshel, J. Phys. Chem {\bf 97}, 8050 (1993))
is applied with a plane-wave basis and both local and non-local
pseudopotentials. This method divides the electron density of the system into
substrate and embedded electron densities, the sum of which is the electron
density of the system of interest. Coupling between the substrate and embedded
systems is achieved via approximate kinetic energy functionals. Bulk aluminium
is examined as a test case for which there is a strong interaction between the
substrate and embedded systems. A number of approximations to the
kinetic-energy functional, both semi-local and non-local, are investigated. It
is found that Kohn-Sham results can be well reproduced using a non-local
kinetic energy functional, with the total energy accurate to better than 0.1 eV
per atom and good agreement between the electron densities.Comment: 11 pages, 4 figure
Recommended from our members
Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors.
Purpose:To evaluate the safety, recommended phase II dose (RP2D) and efficacy of pexidartinib, a colony stimulating factor receptor 1 (CSF-1R) inhibitor, in combination with weekly paclitaxel in patients with advanced solid tumors. Patients and Methods:In part 1 of this phase Ib study, 24 patients with advanced solid tumors received escalating doses of pexidartinib with weekly paclitaxel (80 mg/m2). Pexidartinib was administered at 600 mg/day in cohort 1. For subsequent cohorts, the dose was increased by ⩽50% using a standard 3+3 design. In part 2, 30 patients with metastatic solid tumors were enrolled to examine safety, tolerability and efficacy of the RP2D. Pharmacokinetics and biomarkers were also assessed. Results:A total of 51 patients reported ≥1 adverse event(s) (AEs) that were at least possibly related to either study drug. Grade 3-4 AEs, including anemia (26%), neutropenia (22%), lymphopenia (19%), fatigue (15%), and hypertension (11%), were recorded in 38 patients (70%). In part 1, no maximum tolerated dose was achieved and 1600 mg/day was determined to be the RP2D. Of 38 patients evaluable for efficacy, 1 (3%) had complete response, 5 (13%) partial response, 13 (34%) stable disease, and 17 (45%) progressive disease. No drug-drug interactions were found. Plasma CSF-1 levels increased 1.6- to 53-fold, and CD14dim/CD16+ monocyte levels decreased by 57-100%. Conclusions:The combination of pexidartinib and paclitaxel was generally well tolerated. RP2D for pexidartinib was 1600 mg/day. Pexidartinib blocked CSF-1R signaling, indicating potential for mitigating macrophage tumor infiltration
Multiscale simulations in simple metals: a density-functional based methodology
We present a formalism for coupling a density functional theory-based quantum
simulation to a classical simulation for the treatment of simple metallic
systems. The formalism is applicable to multiscale simulations in which the
part of the system requiring quantum-mechanical treatment is spatially confined
to a small region. Such situations often arise in physical systems where
chemical interactions in a small region can affect the macroscopic mechanical
properties of a metal. We describe how this coupled treatment can be
accomplished efficiently, and we present a coupled simulation for a bulk
aluminum system.Comment: 15 pages, 7 figure
CELL-LINED, NONWOVEN MICROFIBER SCAFFOLDS AS A BLOOD INTERFACE *
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73137/1/j.1749-6632.1977.tb41787.x.pd
Thermodynamic properties of spontaneous magnetization in Chern-Simons QED_3
The spontaneous magnetization in Chern-Simons QED_3 is discussed in a finite
temperature system. The thermodynamical potential is analyzed within the weak
field approximation and in the fermion massless limit. We find that there is a
linear term with respect to the magnetic field with a negative coefficient at
any finite temperature. This implies that the spontaneous magnetic field does
not vanish even at high temperature. In addition, we examine the photon
spectrum in the system. We find that the bare Chern-Simons coefficient is
cancelled by the radiative effects. The photons then become topologically
massless according to the magnetization, though they are massive by finite
temperature effects. Thus the magnetic field is a long-range force without the
screening even at high temperature.Comment: 32 pages, Latex, 4 eps figure
Tikhonov adaptively regularized gamma variate fitting to assess plasma clearance of inert renal markers
The Tk-GV model fits Gamma Variates (GV) to data by Tikhonov regularization (Tk) with shrinkage constant, λ, chosen to minimize the relative error in plasma clearance, CL (ml/min). Using 169Yb-DTPA and 99mTc-DTPA (n = 46, 8–9 samples, 5–240 min) bolus-dilution curves, results were obtained for fit methods: (1) Ordinary Least Squares (OLS) one and two exponential term (E1 and E2), (2) OLS-GV and (3) Tk-GV. Four tests examined the fit results for: (1) physicality of ranges of model parameters, (2) effects on parameter values when different data subsets are fit, (3) characterization of residuals, and (4) extrapolative error and agreement with published correction factors. Test 1 showed physical Tk-GV results, where OLS-GV fits sometimes-produced nonphysical CL. Test 2 showed the Tk-GV model produced good results with 4 or more samples drawn between 10 and 240 min. Test 3 showed that E1 and E2 failed goodness-of-fit testing whereas GV fits for t > 20 min were acceptably good. Test 4 showed CLTk-GV clearance values agreed with published CL corrections with the general result that CLE1 > CLE2 > CLTk-GV and finally that CLTk-GV were considerably more robust, precise and accurate than CLE2, and should replace the use of CLE2 for these renal markers
Structural Invariance of Sunspot Umbrae Over the Solar Cycle: 1993-2004
Measurements of maximum magnetic flux, minimum intensity, and size are
presented for 12 967 sunspot umbrae detected on the NASA/NSO
spectromagnetograms between 1993 and 2004 to study umbral structure and
strength during the solar cycle. The umbrae are selected using an automated
thresholding technique. Measured umbral intensities are first corrected for a
confirming observation of umbral limb-darkening. Log-normal fits to the
observed size distribution confirm that the size spectrum shape does not vary
with time. The intensity-magnetic flux relationship is found to be steady over
the solar cycle. The dependence of umbral size on the magnetic flux and minimum
intensity are also independent of cycle phase and give linear and quadratic
relations, respectively. While the large sample size does show a low amplitude
oscillation in the mean minimum intensity and maximum magnetic flux correlated
with the solar cycle, this can be explained in terms of variations in the mean
umbral size. These size variations, however, are small and do not substantiate
a meaningful change in the size spectrum of the umbrae generated by the Sun.
Thus, in contrast to previous reports, the observations suggest the equilibrium
structure, as testified by the invariant size-magnetic field relationship, as
well as the mean size (i.e. strength) of sunspot umbrae do not significantly
depend on solar cycle phase.Comment: 17 pages, 6 figures. Published in Solar Physic
The Energy Density in the Maxwell-Chern-Simons Theory
A two-dimensional nonrelativistic fermion system coupled to both
electromagnetic gauge fields and Chern-Simons gauge fields is analysed.
Polarization tensors relevant in the quantum Hall effect and anyon
superconductivity are obtained as simple closed integrals and are evaluated
numerically for all momenta and frequencies. The correction to the energy
density is evaluated in the random phase approximation (RPA), by summing an
infinite series of ring diagrams. It is found that the correction has
significant dependence on the particle number density.
In the context of anyon superconductivity, the energy density relative to the
mean field value is minimized at a hole concentration per lattice plaquette
(0.05 \sim 0.06) (p_c a/\hbar)^2 where p_c and a are the momentum cutoff and
lattice constant, respectively. At the minimum the correction is about -5 %
\sim -25 %, depending on the ratio (2m \omega_c)/(p_c^2) where \omega_c is the
frequency cutoff.
In the Jain-Fradkin-Lopez picture of the fractional quantum Hall effect the
RPA correction to the energy density is very large. It diverges logarithmically
as the cutoff is removed, implying that corrections beyond RPA become important
at large momentum and frequency.Comment: 19 pages (plain Tex), 12 figures not included, UMN-TH-1246/9
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