Senso - A real-time interactive mobile system to improve users’ overall skin condition

Healthy skin is a critical part of overall health for everyone and not only important for appearance. Useful information about the skin is often overwhelming, misleading, or difficult to obtain. There are many factors that affect the skin’s condition, from environmental conditions like UV, humidity, or lifestyle factors like diet and the amount of sleep a person gets to specific ingredients in cosmetics. All this makes the effective management of skin health time consuming and inaccurate without knowing where to find the right information. This project explores a theoretical system that is designed to help users understand and manage their skin health by simplifying information and bringing it to the surface. This will enable be more aware of their skin health without being overwhelmed. Using environmental and biometric sensors, along with user generated data, my system is designed to collect a variety of information related to skin health and then present it to users in an accessible and digestible format. The system will perform an analysis to inform users of their overall skin health and of anything that may negatively affect it. Based on each user’s profile and collected data, the system will generate customizable, personal skin care solutions

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Kinematic Simulation of Automatic Conveying and Stamping Machine based on UGNX

This paper designed a kind of automatic conveying and stamping machine, which was mainly used for drawing thin sheet metal. UGNX software was used to design the motion law of the mechanism and the simulation mechanism. The time displacement diagram obtained by theoretical calculation and simulation was compared to verify the correctness of theoretical analysis and the rationality of the design. The comparison shows that the device meets the requirements of theoretical calculation. The device has the characteristics of simple structure, high efficiency and easy operation, which provides a reference for the subsequent realization of conveying and stamping devices with different requirements

The Prognostic Significance of Hsp70 in Patients with Colorectal Cancer Patients: A PRISMA-Compliant Meta-Analysis

Background. Hsp70 (heat shock protein 70) plays a key role in carcinogenesis and cancer progression. However, the relationship between the Hsp70 expression level and the colorectal cancer patient survival is unknown. This study is aimed at investigating the relationship between Hsp70 and the prognosis of colorectal carcinoma patients. Methods. PubMed, Web of Science, and Embase were used for systematic computer literature retrieval. Stata SE14.0 software was used for quantitative meta-analysis. Besides, data was extracted from selected articles. Relationships between Hsp70 expression level and prognosis were further studied. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were also computed. Results. A total of 11 potentially eligible studies with 2269 patients were identified in 10 tumors from PubMed, Web of Science, and Embase. Hsp70 overexpression was associated with poor overall survival (OS) and disease-free survival (DFS) in colorectal carcinoma patients (HRs, 0.65 (95% CI: 0.52-0.78) and 0.77 (95% CI: 0.23-1.32), respectively). Conclusions. Hsp70 overexpression can predict poor survival in colorectal cancer patients

Interaction of Hyperoside with Human Serum Albumin and Effect of Glucose on the Binding

The interaction of hyperoside (Hyp) with human serum albumin (HSA) and effect of glucose on the binding were studied in simulating physiological condition (pH 7.40). The results suggested that Hyp quenched the endogenous fluorescence of HSA via a static quenching process with the distance of 1.95 nm between Hyp and HSA. Hydrophobic forces played a major role in stabilizing the Hyp-HSA complex. Through synchronous fluorescence monitoring of conformation of HSA, we found that the binding to Hyp can change the microenvironment around tryptophan (Trp) residues. Increasing in glucose concentration over a range from 0 to 9 mM decreased the binding ability of HSA to Hyp, implying that increasing in glucose concentration would increase the concentration of free Hyp