DataSheet1_GSK-J1-loaded, hyaluronic acid-decorated metal-organic frameworks for the treatment of ovarian cancer.docx

Despite intensive research, ovarian cancer has the highest mortality rates among gynecological malignancies, partly because of its rapid acquisition of chemoresistance to platinum therapy. Hence, strategies are needed to effectively treat carboplatin-resistant ovarian cancer. In this study, we designed and prepared hyaluronic acid-decorated metal-organic frameworks for the targeted delivery of GSK-J1, a JMJD3 demethylase inhibitor (HA@MOF@GSK-J1) for the synergistic treatment of carboplatin-resistant ovarian cancer. HA@MOF@GSK-J1 showed outstanding effectiveness in the inhibition of ovarian cancer in vitro. Furthermore, HA@MOF@GSK-J1 demonstrated higher induction of apoptosis, reduced cell motility, and diminished cell spheroids by attenuating HER2 activity through the effectual activation of H3K27 methylation in its promoter area. Finally, our in vivo results confirmed that HA@MOF@GSK-J1 had better treatment efficacy for carboplatin-resistant ovarian tumor xenografts. Our results highlight the potential of HA@MOF@GSK-J1 as an effective strategy to improve the treatment of carboplatin-resistant ovarian cancer.</p

DataSheet1_Double cross-linked graphene oxide hydrogel for promoting healing of diabetic ulcers.pdf

This study explores the synthesis and characterization of a novel double cross-linked hydrogel composed of polyvinyl alcohol (PVA), sodium alginate (SA), graphene oxide (GO), and glutathione (GSH), henceforth referred to as PVA/SA/GO/GSH. This innovative hydrogel system incorporates two distinct types of cross-linking networks and is meticulously engineered to exhibit sensitivity to high glucose and/or reactive oxygen species (ROS) environments. A sequential approach was adopted in the hydrogel formation. The initial phase involved the absorption of GSH onto GO, which was subsequently functionalized with boric acid and polyethylene glycol derivatives via a bio-orthogonal click reaction. This stage constituted the formation of the first chemically cross-linked network. Subsequently, freeze-thaw cycles were utilized to induce a secondary cross-linking process involving PVA and SA, thereby forming the second physically cross-linked network. The resultant PVA/SA/GO/GSH hydrogel retained the advantageous hydrogel properties such as superior water retention capacity and elasticity, and additionally exhibited the ability to responsively release GSH under changes in glucose concentration and/or ROS levels. This feature finds particular relevance in the therapeutic management of diabetic ulcers. Preliminary in vitro evaluation affirmed the hydrogel’s biocompatibility and its potential to promote cell migration, inhibit apoptosis, and exhibit antibacterial properties. Further in vivo studies demonstrated that the PVA/SA/GO/GSH hydrogel could facilitate the healing of diabetic ulcer sites by mitigating oxidative stress and regulating glucose levels. Thus, the developed PVA/SA/GO/GSH hydrogel emerges as a promising candidate for diabetic ulcer treatment, owing to its specific bio-responsive traits and therapeutic efficacy.</p

Photocurrent Enhancement of BODIPY-Based Solution-Processed Small-Molecule Solar Cells by Dimerization via the Meso Position

Three 4,4-difluoro-4-bora-3a,4a-diaza-<i>s</i>-indancene (BODIPY)-based small molecule donors <b>H-T-BO</b>, <b>Br-T-BO</b>, and <b>DIMER</b> were synthesized and fully characterized. Although modification at the meso position has a subtle influence on the light-harvesting ability, energy levels, and phase sizes, it has a striking effect on the packing behavior in solid film as two-dimension grazing incidence X-ray diffraction (2D GIXRD) and X-ray diffraction (XRD) confirm. <b>Br-T-BO</b> exhibits better packing ordering than <b>H-T-BO</b> in pristine film, which is beneficial from reinforced intermolecular interaction from halogen atoms. However, when [6,6]-phenyl-C₇₁-butyric acid methyl ester (PC₇₁BM) is blended, no diffraction patterns corresponding to the monomeric donor can be seen from the XRD data and both <b>H-T-BO</b>- and <b>Br-T-BO</b>-based blend films give a slightly blue-shifting absorption peak with respect to their neat ones, both of which imply destruction of the crystalline structure. As for <b>DIMER</b>, the enhancement of the intermolecular interaction arises not only from the expansion of the backbone but the “steric pairing effect” brought on by its twisted structure. When blended with PC₇₁BM, the diffraction patterns of <b>DIMER</b> are, however, kept well and the absorption peak position remains unchanged, which indicates the ordered packing of <b>DIMER</b> is held well in blend film. In coincidence with the fact that packing ordering improves from <b>H-T-BO</b> to <b>Br-T-BO</b> and <b>DIMER</b> in pristine films and the ordered packing of <b>DIMER</b> even in blend film, <b>DIMER</b>-based devices show the highest and most balanced hole/electron mobility of 1.16 × 10^–3/0.90 × 10^–3 cm² V^–1 s^–1with respect to <b>Br-T-BO</b> (4.71 × 10^–4/2.09 × 10^–4 cm² V^–1 s^–1) and <b>H-T-BO</b> (4.27 × 10^–5/1.00 × 10^–5 cm² V^–1 s^–1) based ones. The short-circuit current density of the three molecule-based cells follows the same trend from <b>H-T-BO</b> (6.80) to <b>Br-T-BO</b> (7.62) and then to <b>DIMER</b> (11.28 mA cm^–2). Finally, the <b>H-T-BO</b>-, <b>Br-T-BO</b>-, and <b>DIMER</b>-based optimal device exhibits a power conversion efficiency of 1.56%, 1.96%, and 3.13%, respectively

Efficient and Stable Organic Solar Cells Enabled by Backbone Engineering of Nonconjugated Polymer Zwitterion Interlayers

Improving the efficiency and stability of fused-ring electron acceptor (FREA)-based organic solar cells (OSCs) by interface engineering is presently an emerging topic in the photovoltaic research field. Herein, we propose the design and efficient synthesis of four nonconjugated self-doped polymer zwitterions composed of the same electron-rich dopant but varied electron-deficient host fragments (perylene diimide and naphthalene diimide) and linkages (imidazolium and ammonium). Our results reveal that both their electrical properties and interfacial compatibility with active layers can be fine-tuned by structural modification, therefore impacting the power conversion efficiencies (PCEs) of the OSCs. The zwitterion combining perylene diimide and ammonium exhibits a more suitable energy level, higher conductivity, and more favorable film-forming ability with respect to others, which markedly modify the electrode/active layer interface, promote efficient charge extraction, and diminish charge recombination. This results in improved efficiency and stability of both binary and ternary FREA-based OSCs over a wide range of interlayer thickness with a maximum PCE value of 18.67% and high operational stability with T80 > 800 h (the time scale for solar cell efficiency reaching 80% of the initial value). Our work provides an ingenious way to systematically optimize the molecular structures of nonconjugated polymer zwitterions toward more efficient and robust OSCs

Correlation between Annealing-Induced Growth of Nanocrystals and the Performance of Polymer: Nanocrystals Hybrid Solar Cells

In this work, we investigated the correlation between the inner structure of aqueous solution processed polymer:nanocrystals (NCs) hybrid solar cells and its performance. By altering the compositional concentration, annealing temperature, annealing time, and the thickness of the active layer, the diameter of CdTe NCs increased from 2.8 nm to tens of nanometers. Also, the performance of poly (1,4-phenylene vinylene) (PPV):CdTe hybrid solar cells changed accordingly. Systematical analysis revealed that the best performance of hybrid solar cells was achieved when CdTe was 30 mg/mL and the annealing temperature was above 250 °C with the active layer thickness of about 100 nm. The inner structure showed the size of CdTe NCs was around 26 nm, with the spacing of 6–12 nm. The data of transmission electron microscopy (TEM) and X-ray diffraction (XRD) confirmed that the CdTe NCs grew mainly via dynamic coalescence