Divergent Trideuteromethylthiolation and Aminotrideuteromethylthiolation of Alkenes with <i>N</i>‑Fluorobenzenesulfonimide and CD₃SSO₃Na

A metal-free oxidative trideuteromethylthiolation of alkenes with CD3SSO3Na using NFSI as an oxidant has been developed. The aminotrideuteromethylthiolation of a three-component reaction could be easily achieved in the presence of a cobalt catalyst. The divergent trideuteromethylthiolation of alkenes, readily available trideuteromethylthiolation reagent, and versatile synthetic strategy allow for late-stage modification of drug molecules

Recruitment of family caregiver participants.

<p>Recruitment of family caregiver participants.</p

Demographic characteristics of informal caregivers and disabled elders.

<p>Demographic characteristics of informal caregivers and disabled elders.</p

Correlation with Spearman’s rho between the depressive emotion and the care burden of informal caregivers and the quality of life of disabled elders (N = 444).

<p>Correlation with Spearman’s rho between the depressive emotion and the care burden of informal caregivers and the quality of life of disabled elders (N = 444).</p

Tests of independent means in comparing effects of the lack and presence of depressive emotion on the care burden of informal caregivers and quality of life of disabled elders.

<p>Tests of independent means in comparing effects of the lack and presence of depressive emotion on the care burden of informal caregivers and quality of life of disabled elders.</p

Multivariate logistic regression analysis: Factors associated with the depressive emotion among the informal caregivers of disabled elders (N = 444).

<p>Multivariate logistic regression analysis: Factors associated with the depressive emotion among the informal caregivers of disabled elders (N = 444).</p

Additional file 1: of Proteomic analysis of human follicular fluid associated with successful in vitro fertilization

The information of antibodies and secondaries for Western blotting. (XLSX 10 kb

Additional file 2: of Proteomic analysis of human follicular fluid associated with successful in vitro fertilization

The overlap of known data and novel findings. (JPEG 1344 kb

DataSheet_1_Comparative and phylogenetic analysis of complete chloroplast genomes from five Artemisia species.docx

Artemisia Linn. is a large genus within the family Asteraceae that includes several important medicinal plants. Because of their similar morphology and chemical composition, traditional identification methods often fail to distinguish them. Therefore, developing an effective identification method for Artemisia species is an urgent requirement. In this study, we analyzed 15 chloroplast (cp) genomes, including 12 newly sequenced genomes, from 5 Artemisia species. The cp genomes from the five Artemisia species had a typical quadripartite structure and were highly conserved across species. They had varying lengths of 151,132–151,178 bp, and their gene content and codon preferences were similar. Mutation hotspot analysis identified four highly variable regions, which can potentially be used as molecular markers to identify Artemisia species. Phylogenetic analysis showed that the five Artemisia species investigated in this study were sister branches to each other, and individuals of each species formed a monophyletic clade. This study shows that the cp genome can provide distinguishing features to help identify closely related Artemisia species and has the potential to serve as a universal super barcode for plant identification.</p