Pointwise Weighted Approximation of Functions with Endpoint Singularities by Combinations of Bernstein Operators

We give direct and inverse theorems for the weighted approximation of functions with endpoint singularities by combinations of Bernstein operators

Air Pollution and Parkinson’s Disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease of unclear etiology that is thought to be caused by a combination of genetic and environmental factors. Air pollution, the largest environmental health risk globally, has been suggested to be associated with PD risk, while not all results are uniform. In this chapter, we summarize the recent advances in the epidemiology of six criteria air pollutants-fine particulate matter (PM2.5), inhalable particles (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide(CO), and ozone exposure with PD risk, and provided an overview of the potential mechanisms of air pollution on PD. Based on the current evidence from the human’s studies and animal models, this chapter provides a novel insight for the understanding of how environmental exposure influences the pathogenesis of neurodegeneration and prevents the occurrence or development of PD

miR-24 Regulates Apoptosis by Targeting the Open Reading Frame (ORF) Region of FAF1 in Cancer Cells

BACKGROUND: microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs at the post-transcriptional stage. Several studies have shown that miRNAs modulate gene expression in mammalian cells by base pairing to complementary sites in the 3'-untranslated region (3'-UTR) of the target mRNAs. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, miR-24 was found to target fas associated factor 1(FAF1) by binding to its amino acid coding sequence (CDS) region, thereby regulating apoptosis in DU-145 cells. This result supports an augmented model whereby animal miRNAs can exercise their effects through binding to the CDS region of the target mRNA. Transfection of miR-24 antisense oligonucleotide (miR-24-ASO) also induced apoptosis in HGC-27, MGC-803 and HeLa cells. CONCLUSIONS/SIGNIFICANCE: We found that miR-24 regulates apoptosis by targeting FAF1 in cancer cells. These findings suggest that miR-24 could be an effective drug target for treatment of hormone-insensitive prostate cancer or other types of cancers. Future work may further develop miR-24 for therapeutic applications in cancer biology

Event-assisted Low-Light Video Object Segmentation

In the realm of video object segmentation (VOS), the challenge of operating under low-light conditions persists, resulting in notably degraded image quality and compromised accuracy when comparing query and memory frames for similarity computation. Event cameras, characterized by their high dynamic range and ability to capture motion information of objects, offer promise in enhancing object visibility and aiding VOS methods under such low-light conditions. This paper introduces a pioneering framework tailored for low-light VOS, leveraging event camera data to elevate segmentation accuracy. Our approach hinges on two pivotal components: the Adaptive Cross-Modal Fusion (ACMF) module, aimed at extracting pertinent features while fusing image and event modalities to mitigate noise interference, and the Event-Guided Memory Matching (EGMM) module, designed to rectify the issue of inaccurate matching prevalent in low-light settings. Additionally, we present the creation of a synthetic LLE-DAVIS dataset and the curation of a real-world LLE-VOS dataset, encompassing frames and events. Experimental evaluations corroborate the efficacy of our method across both datasets, affirming its effectiveness in low-light scenarios.Comment: CVPR 202

Spatial distribution of job opportunities in China: Evidence from the opening of the high-speed rail

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.The provision of sufficient job opportunities has traditionally been a primary objective for both local and central governments. In response to this concern, we investigate spatial dependence of job opportunities among 30 Chinese provincial capital cities (PCCs) from 2002 to 2016, giving special attention to the spatial spillovers of the opening of the high-speed rail (HSR). Using appropriate spatial panel data models, our findings suggest the presence of significant spatial autocorrelation of job opportunities among PCCs. Whilst the HSR has been found to increase job opportunities at the national level, which, however, is not confirmed at the regional level. The spatial spillover effects of the HSR are significant and positive only in the eastern/northeastern region. These findings can help the central government to more fully understand spatial dependence of job opportunities, better plan future HSR networks, and efficiently allocate transportation resources, encouraging cross-regional collaboration to promote regional employment

Genetic associations between gut microbiota and allergic rhinitis: an LDSC and MR analysis

BackgroundSeveral studies have suggested a potential link between allergic rhinitis (AR) and gut microbiota. In response, we conducted a meta-analysis of Linkage Disequilibrium Score Regression (LDSC) and Mendelian randomization (MR) to detect their genetic associations.MethodsSummary statistics for 211 gut microbiota taxa were gathered from the MiBioGen study, while data for AR were sourced from the Pan-UKB, the FinnGen, and the Genetic Epidemiology Research on Aging (GERA). The genetic correlation between gut microbiota and AR was assessed using LDSC. The principal estimate of causality was determined using the Inverse-Variance Weighted (IVW) method. To assess the robustness of these findings, sensitivity analyses were conducted employing methods such as the weighted median, MR-Egger, and MR-PRESSO. The summary effect estimates of LDSC, forward MR and reverse MR were combined using meta-analysis for AR from different data resources.ResultsOur study indicated a significant genetic correlation between genus Sellimonas (Rg = −0.64, p = 3.64 × 10−5, Adjust_P = 3.64 × 10−5) and AR, and a suggestive genetic correlation between seven bacterial taxa and AR. Moreover, the forward MR analysis identified genus Gordonibacter, genus Coprococcus2, genus LachnospiraceaeUCG010, genus Methanobrevibacter, and family Victivallaceae as being suggestively associated with an increased risk of AR. The reverse MR analysis indicated that AR was suggestively linked to an increased risk for genus Coprococcus2 and genus RuminococcaceaeUCG011.ConclusionOur findings indicate a causal relationship between specific gut microbiomes and AR. This enhances our understanding of the gut microbiota’s contribution to the pathophysiology of AR and lays the groundwork for innovative approaches and theoretical models for future prevention and treatment strategies in this patient population

Single and combined strategies for mesenchymal stem cell exosomes alleviate liver fibrosis: a systematic review and meta-analysis of preclinical animal models

Background: The efficacy of mesenchymal stem cells (MSCs) in treating liver fibrosis has been supported by various clinical studies. However, stem cell transplantation is limited in clinical application due to its low survival rate, low liver implantation rate, and possible carcinogenicity. Recently, there has been increasing interest in the use of MSC-exos due to their widespread availability, low immunogenicity, and non-carcinogenic properties. Numerous studies have demonstrated the potential of MSC-exos in treating liver fibrosis and preventing progression to end-stage liver disease.Objective: This study aimed to systematically investigate the efficacy of MSC-exos single administration in the treatment of hepatic fibrosis and the combined advantages of MSC-exos in combination with drug therapy (MSC-exos-drugs).Methods: Data sources included PubMed, Web of Science, Embase, and the Cochrane Library, which were built up to January 2024. The population, intervention, comparison, outcomes, and study design (PICOS) principle was used to screen the literature, and the quality of the literature was evaluated to assess the risk of bias. Finally, the data from each study’s outcome indicators were extracted for a combined analysis.Results: After screening, a total of 18 papers (19 studies) were included, of which 12 involved MSC-exos single administration for the treatment of liver fibrosis and 6 involved MSC-exos-drugs for the treatment of liver fibrosis. Pooled analysis revealed that MSC-exos significantly improved liver function, promoted the repair of damaged liver tissue, and slowed the progression of hepatic fibrosis and that MSC-exos-drugs were more efficacious than MSC-exos single administration. Subgroup analyses revealed that the use of AD-MSC-exos resulted in more consistent and significant efficacy when MSC-exos was used to treat hepatic fibrosis. For MSC-exos-drugs, a more stable end result is obtained by kit extraction. Similarly, infusion through the abdominal cavity is more effective.Conclusion: The results suggest that MSC-exos can effectively treat liver fibrosis and that MSC-exos-drugs are more effective than MSC-exos single administration. Although the results of the subgroup analyses provide recommendations for clinical treatment, a large number of high-quality experimental validations are still needed.Systematic Review Registration: CRD42024516199

The Genomes of Oryza sativa: A History of Duplications

We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested against a nonredundant collection of 19,079 full-length cDNAs, 97.7% of the genes are aligned, without fragmentation, to the mapped super-scaffolds of one or the other genome. We introduce a gene identification procedure for plants that does not rely on similarity to known genes to remove erroneous predictions resulting from transposable elements. Using the available EST data to adjust for residual errors in the predictions, the estimated gene count is at least 38,000–40,000. Only 2%–3% of the genes are unique to any one subspecies, comparable to the amount of sequence that might still be missing. Despite this lack of variation in gene content, there is enormous variation in the intergenic regions. At least a quarter of the two sequences could not be aligned, and where they could be aligned, single nucleotide polymorphism (SNP) rates varied from as little as 3.0 SNP/kb in the coding regions to 27.6 SNP/kb in the transposable elements. A more inclusive new approach for analyzing duplication history is introduced here. It reveals an ancient whole-genome duplication, a recent segmental duplication on Chromosomes 11 and 12, and massive ongoing individual gene duplications. We find 18 distinct pairs of duplicated segments that cover 65.7% of the genome; 17 of these pairs date back to a common time before the divergence of the grasses. More important, ongoing individual gene duplications provide a never-ending source of raw material for gene genesis and are major contributors to the differences between members of the grass family

Expert Consensus on Microtransplant for Acute Myeloid Leukemia in Elderly Patients -Report From the International Microtransplant Interest Group

Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MST, especially MST with EAML from January 1st, 2011 to November 30th, 2022, the International Microtransplant Interest Group provides recommendations and considerations for MST in the treatment of EAML. Four major issues related to MST for treating EAML were addressed: therapeutic principle of MST (1), candidates for MST (2), induction chemotherapy regimens (3), and post-remission therapy based on MST (4). Others included donor screening, infusion of donor cells, laboratory examinations, and complications of treatment