Demographic characteristics and haplotypic distributions of the 3′ untranslated region (UTR) of <i>GRP78</i> gene among cases with HCC.

<p>*Chi-square test.</p><p>AFP, <i>α</i>-fetoprotein; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; TNM, tumor, nodes, metastasis-classification.</p

Kaplan-Meier survival curves show that overall survivals of 576 cases with HCC were not associated with the different alleles, genotypes, haplotypes and diplotypes in the <i>GRP78</i> gene including rs16927997, rs1140763 and rs12009.

<p><i>P</i> value was calculated using a log-rank test. The wildtype alleles, homozygotes, and the corresponding haplotype and diplotype were designated as the referent.</p

Univariate survival analyses of possible prognostic factors.

<p>AFP, <i>α</i>-fetoprotein; HBV, hepatitis B virus; NS, not significant; TNM, tumor, nodes, metastasis-classification.</p

Genotype distribution of rs430397 G>A in the fifth intron of the <i>GRP78</i> gene in HBV-infected individuals with different HBeAg states.

<p>CHB, chronic hepatitis B; CHC, chronic hepatitis B virus carrier; HBeAg, hepatitis B e antigen; HBV, hepatitis B virus; IHC, inactive hepatitis B surface antigen carrier; LC, liver cirrhosis.</p><p>*Compared with the phase I group, <i>x²</i> = 7.562 and <i>P</i> = 0.006; and compared with the phase III group, <i>x²</i> = 5.969 and <i>P</i> = 0.015.</p>†<p>Compared with the phase I group, <i>x²</i> = 8.039 and <i>P</i> = 0.005; and compared with the phase III group, <i>x²</i> = 4.883 and <i>P</i> = 0.027.</p>‡<p>Compared with the phase I group, <i>x²</i> = 7.131 and <i>P</i> = 0.008.</p

Relationship between rs430397 G>A distribution and liver functional profiles in patients with liver cirrhosis.

<p>SD, standard deviation; T-Bil, total bilirubin; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyltransferase; PT, prothrombin time.</p><p>*Compared with the GG group, <i>x²</i> = 4.461 and <i>P</i> = 0.029.</p>†<p>Compared with the GG group, <i>x²</i> = 5.832 and <i>P</i> = 0.016.</p

Comparison between advanced and mild liver cirrhosis patients according to Child-Pugh score.

<p>*Mann-Whitney U-test.</p>†<p>Pearson Chi-square test.</p>‡<p>Multivariable logistic regression analysis adjusted with age and gender.</p>§<p>Child-Pugh classification.</p

rs430397 G>A polymorphism and cirrhosis risk in HBV patients.

<p>*Pearson Chi-square test.</p>†<p>Multivariable logistic regression analysis adjusted with age and gender.</p

Clinical and laboratory features of the subjects included in the study.

<p>ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CHB, chronic hepatitis B; CHC, chronic hepatitis B virus carrier; CT, computed tomography; GGT, γ-glutamyltransferase; HBV, hepatitis B virus; IHC, inactive hepatitis B surface antigen carrier; LC, liver cirrhosis; MRI, Magnetic resonance imaging; PT, prothrombin time; SD, standard deviation;. T-Bil, total bilirubin.</p

Additional file 1: of A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

Table S1. A case-control study in the discovery study with targeted NGS. (XLS 37 kb

Association results of the two SNPs with risk of <i>S. japonicum</i> infection in the discovery, replicative and combined studies.

<p>Adjusted for age, gender, smoking and drinking.</p><p><i>P</i><1.163×10⁻³ means significant value by Bonferroni correction based on the total number of markers genotyped.</p