942 research outputs found
Hexaaquacobalt(II) tetraaquabis(2-aminopyrazine-κN 4)cobalt(II) disulfate dihydrate
The reaction of cobalt(II) sulfate and 2-aminopyrazine affords the title salt, [Co(H2O)6][Co(C4H5N3)2(H2O)4](SO4)2·2H2O. The metal atoms in the tetraaqua-coordinated and hexaaqua-coordinated complex cations lie on centers of inversion in slightly distorted octahedral geometries. The cations, anions and solvent water molecules are linked by O—H⋯O, O—H⋯N and N—H⋯O hydrogen bonds into a three-dimensional network
μ-Adipato-κ2 O 1:O 4-bis{[2,6-bis(1H-benzimidazol-2-yl-κN 3)pyridine-κN](nitrato-κO)lead(II)}
The dinuclear title compound, [Pb2(C6H8O4)(NO3)2(C19H13N5)2], lies with the mid-point of the butyl chain of the bridging adipate unit on a center of inversion. The PbII ion is covalently bonded to the nitrate anion and is bonded to a carboxylate group of the adipate unit by another covalent bond. The N-heterocycle functions in a chelating tridentate mode. The metal atom exists in a Ψ-octahedral coordination environment. When weaker Pb⋯O interactions are also considered, the geometry is a Ψ-tricapped trigonal prism in which the lone-pair electrons occupy one face of the trigonal prism. Adjacent molecules are linked into a layer structure by N—H⋯O hydrogen bonds
Survivin is a prognostic marker and therapeutic target for extranodal, nasal-type natural killer/T cell lymphoma.
Background: The relationship between survivin and extranodal, nasal-type natural killer/T cell lymphoma (ENKTCL) was unclearly established yet. We here studied the potential prognostic roles of survivin and its implication as a target in ENKTCL therapy.
Methods: ENKTCL patients\u27 peripheral blood were collected and tested by ELISA. ENKTCL cell lines were cultured with or without survivin inhibitor and tested by MTT and Flow cytometry. According to the gene expression profiles from the ArrayExpress Archive under E-TABM-702, survivin co-regulated cluster was established by Coupled Two-way Clustering Algorithm.
Results: Seventeen point six percent of total 17 ENKTCL patients were serum survivin-positive. These patients had poorer outcome than that of negative cases (P
Conclusions: We concluded that survivin was a potential prognostic marker and a critical regulatory molecule in the pathological process of ENKTCL. It would be a promising target in drugs discovery for ENKTCL therapy
Magnetic Borophenes from an Evolutionary Search
A computational methodology based on ab initio evolutionary algorithms and spin-polarized density functional theory was developed to predict two-dimensional magnetic materials. Its application to a model system borophene reveals an unexpected rich magnetism and polymorphism. A metastable borophene with nonzero thickness is an antiferromagnetic semiconductor from first-principles calculations, and can be further tuned into a half-metal by finite electron doping. In this borophene, the buckling and coupling among three atomic layers are not only responsible for magnetism, but also result in an out-of-plane negative Poisson\u27s ratio under uniaxial tension, making it the first elemental material possessing auxetic and magnetic properties simultaneously
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A comparative study of pre-trained language models for named entity recognition in clinical trial eligibility criteria from multiple corpora
Background
Clinical trial protocols are the foundation for advancing medical sciences, however, the extraction of accurate and meaningful information from the original clinical trials is very challenging due to the complex and unstructured texts of such documents. Named entity recognition (NER) is a fundamental and necessary step to process and standardize the unstructured text in clinical trials using Natural Language Processing (NLP) techniques.
Methods
In this study we fine-tuned pre-trained language models to support the NER task on clinical trial eligibility criteria. We systematically investigated four pre-trained contextual embedding models for the biomedical domain (i.e., BioBERT, BlueBERT, PubMedBERT, and SciBERT) and two models for the open domains (BERT and SpanBERT), for NER tasks using three existing clinical trial eligibility criteria corpora. In addition, we also investigated the feasibility of data augmentation approaches and evaluated their performance.
Results
Our evaluation results using tenfold cross-validation show that domain-specific transformer models achieved better performance than the general transformer models, with the best performance obtained by the PubMedBERT model (F1-scores of 0.715, 0.836, and 0.622 for the three corpora respectively). The data augmentation results show that it is feasible to leverage additional corpora to improve NER performance.
Conclusions
Findings from this study not only demonstrate the importance of contextual embeddings trained from domain-specific corpora, but also shed lights on the benefits of leveraging multiple data sources for the challenging NER task in clinical trial eligibility criteria text
Solution to Satisfiability problem by a complete Grover search with trapped ions
The main idea in the original Grover search (Phys. Rev. Lett. 79, 325 (1997))
is to single out a target state containing the solution to a search problem by
amplifying the amplitude of the state, following the Oracle's job, i.e., a
black box giving us information about the target state. We design quantum
circuits to accomplish a complete Grover search involving both the Oracle's job
and the amplification of the target state, which are employed to solve
Satisfiability (SAT) problems. We explore how to carry out the quantum circuits
by currently available ion-trap quantum computing technology.Comment: 14 pages, 6 figure
Bubble in the Whale: Identifying the Optical Counterparts and Extended Nebula for the Ultraluminous X-ray Sources in NGC 4631
We present a deep optical imaging campaign on the starburst galaxy NGC 4631
with CFHT/MegaCam. By supplementing the HST/ACS and Chandra/ACIS archival data,
we search for the optical counterpart candidates of the five brightest X-ray
sources in this galaxy, four of which are identified as ultraluminous X-ray
sources (ULXs). The stellar environments of the X-ray sources are analyzed
using the extinction-corrected color-magnitude diagrams and the isochrone
models. We discover a highly asymmetric bubble nebula around X4 which exhibits
different morphology in the H and [O III] images. The [O III]/H
ratio map shows that the H-bright bubble may be formed mainly via the
shock ionization by the one-sided jet/outflow, while the more compact [O III]
structure is photoionized by the ULX. We constrain the bubble expansion
velocity and interstellar medium density with the MAPPINGS V code, and hence
estimate the mechanical power injected to the bubble as erg s and the corresponding bubble age of yr. Relativistic jets are needed to provide such level of mechanical
power with a mass-loss rate of . Besides
the accretion, the black hole spin is likely an additional energy source for
the super-Eddington jet power.Comment: 17 pages, 10 figures, accepted by Ap
Molecular Cloning and Analysis of the Tryptophan oxygenase Gene in the Silkworm, Bombyx mori
A Bombyx mori L. (Lepidoptera: Bombycidae) gene encoding tryptophan oxygenase has been molecularly cloned and analyzed. The tryptophan oxygenase cDNA had 1374 nucleotides that encoded a 401 amino acid protein with an estimated molecular mass of 46.47 kDa and a PI of 5.88. RT-PCR analysis showed that the B. mori tryptophan oxygenase gene was transcribed in all examined stages. Tryptophan oxygenase proteins are relatively well conserved among different orders of arthropods
Turning on fluorescence by plasmonic assembly with large tunable spacing: a new observation and its biosensing application
NSFC [21127005]; 973 Program [2013CB933703]; Doctoral Fund of MOE [20110121110011]; MOEAssembling nanoparticle-film metallic junctions with a spacing of up to tens of nanometers efficiently turned on fluorophores attached to the film from the quenching status to an intense surface plasmon-coupled emission. Benefiting from this new finding, a fluorescence biosensor was created based on the use of a biomolecule-linked plasmonic assembly as the trigger
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