Proportion of patients retained in care on December 31, 2012, at the national level in South Africa among 55,836 patients initiating ART in 2004–2006 by district of enrollment.

<p>Proportion retained in care was categorized in quintiles. Districts: BUF, Buffalo City; CPT, City of Cape Town; DC1, West Coast; DC2, Cape Winelands; DC3, Overberg; DC4, Eden; DC5, Central Karoo; DC6, Namakwa; DC7, Pixley ka Seme; DC8, Siyanda; DC9, Frances Baard; DC10, Cacadu; DC12, Amathole; DC13, Chris Hani; DC14, Ukhahlamba; DC15, O. R. Tambo; DC16, Xhariep; DC18, Lejweleputswa; DC19, Thabo Mofutsanyana; DC20, Fezile Dabi; DC21, Ugo; DC22, UMgungundlovu; DC23, Uthukela; DC24, Umzinyathi; DC25, Amajuba; DC26, Zululand; DC27, Umkhanyakude; DC28, Uthungulu; DC29, iLembe; DC30, Gert Sibande; DC31, Nkangala; DC32, Ehlanzeni; DC33, Mopani; DC34, Vhembe; DC35, Capricorn; DC36, Waterberg; DC37, Bojanala; DC38, Ngaka Modiri Molema; DC39, Dr Ruth Segomotsi Mompati; DC40, Dr Kenneth Kaunda; DC42, Sedibeng; DC43, Sisonke; DC44, Alfred Nzo; DC45, John Taolo Gaetsewe; DC47, Greater Sekhukhune; DC48, W. Rand; EKU, Ekurhuleni; ETH, eThekwini; JHB, Johannesburg; LS, Lesotho; MAN, Mangaung; NMA, Nelson Mandela Bay Metro; TSH, City of Tshwane. NHLS, National Health Laboratory Service.</p

Retention (as of December 31, 2012) at the national level in South Africa among 55,836 patients initiating ART from 2004–2006 stratified by province of enrollment.

<p>EC, Eastern Cape; FS, Free State; GP, Gauteng; LP, Limpopo; MP, Mpumalanga; NC, Northern Cape; NW, North West; WC, Western Cape.</p

Effect of patient transfer on retention estimates overall in South Africa among 55,836 patients initiating ART in 2004–2006, with attrition defined as retained in care on December 31, 2012.

<p>Effect of patient transfer on retention estimates overall in South Africa among 55,836 patients initiating ART in 2004–2006, with attrition defined as retained in care on December 31, 2012.</p

Retention (as of December 31, 2012) at the national level in South Africa among 55,836 patients initiating ART in 2004–2006 stratified by age.

<p>Retention (as of December 31, 2012) at the national level in South Africa among 55,836 patients initiating ART in 2004–2006 stratified by age.</p

Retention (as of December 31, 2012) at the national level in South Africa among 55,836 patients initiating ART in 2004–2006 stratified by sex.

<p>Retention (as of December 31, 2012) at the national level in South Africa among 55,836 patients initiating ART in 2004–2006 stratified by sex.</p

Movement between clinics by province of initiation and province transferred to (<i>n =</i> 55,836).

<p>Movement between clinics by province of initiation and province transferred to (<i>n =</i> 55,836).</p

Characteristics of patients in South Africa’s national HIV cohort stratified by province (<i>n =</i> 55,836).

<p>Characteristics of patients in South Africa’s national HIV cohort stratified by province (<i>n =</i> 55,836).</p

Retention by CD4 count at first viral load (retained in care on December 31, 2012) at the national level in South Africa among 55,836 patients initiating ART in 2004–2006 (retrospective definition).

<p>Retention by CD4 count at first viral load (retained in care on December 31, 2012) at the national level in South Africa among 55,836 patients initiating ART in 2004–2006 (retrospective definition).</p

Crude and adjusted relative risk calculations for mutation prevalence and drug resistance call between different groups.

<p>Log-binomial regression analysis was used and the model was adjusted with CD4, VL and time on treatment where possible. Adjusted relative risk was only calculated for N: Number of patients; RR: relative risk; CI: confidence interval; VL: RNA Viral Load; ART: antiretroviral treatment; 3TC: lamivudine; FTC: emtricitabine; ABC: abacavir; AZT: zidovudine; d4T: stavudine; ddI: didanosine; TDF: tenofovir; EFV: efavirenz; ETR: etravirine; NVP: nevirapine; RPV: rilpivirine; S: susceptible; IR: intermediate resistance; HR: high-level resistance; ND: not done</p><p>Crude and adjusted relative risk calculations for mutation prevalence and drug resistance call between different groups.</p

Adjusted^* hazard ratios of predictors of national-level attrition in South Africa’s national ART program (<i>n =</i> 55,836).

<p>Adjusted^{<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002589#t003fn001" target="_blank">*</a>} hazard ratios of predictors of national-level attrition in South Africa’s national ART program (<i>n =</i> 55,836).</p