774 research outputs found
Relative incidence and predictors of pulmonary arterial hypertension complicating type 2 diabetes: The Fremantle Diabetes Study Phase I
Aims: To determine the relative incidence and predictors of pulmonary arterial hypertension (PAH) in type 2 diabetes.
Methods: Hospitalizations for/with and death from/with PAH, and all-cause mortality, were ascertained from validated databases for participants from the longitudinal, community-based Fremantle Diabetes Study Phase I (FDS1; n = 1287) and age-, sex- and zip code-matched people without diabetes (n = 5153) between entry (1993–1996) and end-2017. Incidence rates (IRs) and IR ratios (IRRs) were calculated. Cox proportional hazards and competing risk models generated cause-specific (cs) and subdistribution (sd) hazard ratios (HRs) for incident PAH.
Results: In the pooled cohort (mean age 64.0 years, 49% males), 49 (3.8%) of the type 2 diabetes participants and 133 (2.6%) of those without diabetes developed PAH during 106,556 person-years of follow-up (IRs (95% CI) 262 (194– 346) and 151 (127–179) /100,000 person-years, respectively; IRR 1.73 (1.22–2.42), P = 0.001). Type 2 diabetes was associated with an unadjusted csHR of 1.97 (1.42–2.74) and sdHR of 1.44 (1.04–2.00) (P ≤ 0.03); after adjustment for age, sex, and co-morbidities, these were 1.43 (0.83–2.47) and 1.36 (0.97–1.91), respectively (P ≥ 0.07).
Conclusions: Type 2 diabetes is associated with an increased risk of PAH but this is no longer significant after adjustment for other explanatory variables and the competing risk of death.
© 2020 Elsevier Inc. All rights reserved
Gestational Hormone Profiles Predict Human Maternal Behavior at 1-Year Postpartum
In many non-human species, including primates, gestational reproductive hormones play an essential role in the onset of maternal motivation and behaviors. We investigated the associations between prepartum estradiol and progesterone and maternal behavior at 1-year postpartum in 177 women. Blood was obtained at five gestational time points and an index of quality of maternal care was determined using a well-validated mother-child interaction protocol. Women who exhibited higher quality maternal care at 1-year postpartum were characterized by unique gestational profiles of estradiol, progesterone and the estrogen to progesterone ratio; specifically by slower accelerations and levels of these hormone trajectories beginning in midgestation. Further, it appeared that both fetal sex and parity moderated these findings, with first time mothers and mothers of females showing stronger associations. In sum, these data document persisting associations between prepartum hormone profiles and human maternal behavior. More broadly, these findings add to the growing literature highlighting the perinatal period as one of critical neurodevelopment in the lifespan of the human female
Implementing an Open Link Service for the World Wide Web
Links are the key element for changing a text into a hypertext, and yet the WWW provides limited linking facilities. Modelled on Open Hypermedi
Comparing intra-abdominal pressures in different body positions via a urinary catheter and nasogastric tube: a pilot study
Reviews
Review of Jurisdiction under the Industrial Relations Act 1973: Some Problems and Issues, Employment: Towards an Active Employment Policy, Labor in the American Economy, Strikes and Participation, Democracy in the Work Place
A revised Cepheid distance to NGC 4258 and a test of the distance scale
In a previous paper (Maoz et al. 1999), we reported a Hubble Space Telescope
(HST) Cepheid distance to the galaxy NGC 4258 obtained using the calibrations
and methods then standard for the Key Project on the Extragalactic Distance
Scale. Here, we reevaluate the Cepheid distance using the revised Key Project
procedures described in Freedman et al. (2001). These revisions alter the zero
points and slopes of the Cepheid Period-Luminosity (P-L) relations derived at
the Large Magellanic Cloud (LMC), the calibration of the HST WFPC2 camera, and
the treatment of metallicity differences. We also provide herein full
information on the Cepheids described in Maoz et al. 1999. Using the refined
Key Project techniques and calibrations, we determine the distance modulus of
NGC 4258 to be 29.47 +/- 0.09 mag (unique to this determination) +/- 0.15 mag
(systematic uncertainties in Key Project distances), corresponding to a metric
distance of 7.8 +/- 0.3 +/- 0.5 Mpc and 1.2 sigma from the maser distance of
7.2 +/- 0.5 Mpc. We also test the alternative Cepheid P-L relations of Feast
(1999), which yield more discrepant results. Additionally, we place weak limits
upon the distance to the LMC and upon the effect of metallicity in Cepheid
distance determinations.Comment: 26 pages in emulateapj5 format, including 6 figures and 5 tables.
Accepted for publication in the Astrophysical Journa
Parity, mode of birth, and long-term gynecological health: A follow-up study of parous and nonporous women in the Australian Longitudinal Study on Women's Health cohort
Background:Although gynecological health issues are common and cause considerable distress, little is known about their causes. We examined how birth history is associated with urinary incontinence (UI), severe period pain, heavy periods, and endometriosis. Methods:We studied 7700 women in the Australian Longitudinal Study on Women's Health with an average follow-up of 10.9 years after their last birth. Surveys every third year provided information about birth history and gynecological health. Logistic regression was used to estimate how parity, mode of birth, and vaginal tears were associated with gynecological health issues. Presented results are adjusted odds ratios (OR) with 95% confidence intervals. Results:UI was reported by 16%, heavy periods by 31%, severe period pain by 28%, and endometriosis by 4%. Compared with women with two children, nonparous women had less UI (OR 0.35 [0.26–0.47]) but tended to have more endometriosis (OR 1.70 [0.97–2.96]). Also, women with only one child had less UI (OR 0.77 [0.61–0.98]), but more severe period pain (OR 1.24 [1.01–1.51]). Women with 4+ children had more heavy periods (OR 1.42 [1.07–1.88]). Compared with women with vaginal birth(s) only, women with only cesarean sections or vaginal birth after cesarean section had less UI (ORs 0.44 [0.34–0.58] and 0.55 [0.40–0.76]), but more endometriosis (ORs 1.91 [1.16–3.16] and 2.31 [1.25–4.28]) and heavy periods (ORs 1.21 [1.00–1.46] and 1.35 [1.06–1.72]). Vaginal tear(s) did not increase UI after accounting for parity and birth mode. Conclusion:While women with vaginal childbirth(s) reported more urinary incontinence, they had less menstrual complaints and endometriosis.</p
A Cepheid Distance to NGC 4603 in Centaurus
In an attempt to use Cepheid variables to determine the distance to the
Centaurus cluster, we have obtained images of NGC 4603 with the Hubble Space
Telescope on 9 epochs using WFPC2 and the F555W and F814W filters. This galaxy
has been suggested to lie within the ``Cen30'' portion of the cluster and is
the most distant object for which this method has been attempted. Previous
distance estimates for Cen30 have varied significantly and some have presented
disagreements with the peculiar velocity predicted from redshift surveys,
motivating this investigation. Using our observations, we have found 61
candidate Cepheid variable stars; however, a significant fraction of these
candidates are likely to be nonvariable stars whose magnitude measurement
errors happen to fit a Cepheid light curve of significant amplitude for some
choice of period and phase. Through a maximum likelihood technique, we
determine that we have observed 43 +/- 7 real Cepheids and that NGC 4603 has a
distance modulus of 32.61 +0.11/-0.10 (random, 1 sigma) +0.24/-0.25
(systematic, adding in quadrature), corresponding to a distance of 33.3 Mpc.
This is consistent with a number of recent estimates of the distance to NGC
4603 or Cen30 and implies a small peculiar velocity consistent with predictions
from the IRAS 1.2 Jy redshift survey if the galaxy lies in the foreground of
the cluster.Comment: Accepted for publication in the Astrophysical Journal. 17 pages with
17 embedded figures and 3 tables using emulateapj.sty. Additional figures and
images may be obtained from http://astro.berkeley.edu/~marc/n4603
Traditional and Health-Related Philanthropy: The Role of Resources and Personality
I study the relationships of resources and personality characteristics to charitable giving, postmortem organ donation, and blood donation in a nationwide sample of persons in households in the Netherlands. I find that specific personality characteristics are related to specific types of giving: agreeableness to blood donation, empathic concern to charitable giving, and prosocial value orientation to postmortem organ donation. I find that giving has a consistently stronger relation to human and social capital than to personality. Human capital increases giving; social capital increases giving only when it is approved by others. Effects of prosocial personality characteristics decline at higher levels of these characteristics. Effects of empathic concern, helpfulness, and social value orientations on generosity are mediated by verbal proficiency and church attendance.
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