Safety outcomes.

<p>Data are presented as number of subjects or mean (range) where appropriate.</p

Biopsy characteristics.

<p>Data are presented as mean and range or mean and standard deviation where appropriate. Biopsy location is reported per subject. Percentages are calculated relative to total number of clinical biopsy subjects (n = 25).</p

Subject characteristics.

<p>Mean (range) or number (percentage) are presented as appropriate for demographic information. Pulmonary function tests are reported as mean (standard deviation). DLCO is reported corrected for hemoglobin when available.</p

Bronchoscopic cryobiopsy identifies characteristic histopathology from multiple DPLDs.

<p>Representative hematoxylin and eosin stained cryobiopsies from subjects with cryptogenic organizing pneumonia (A) 100x and (B) 400×, (C) bronchiolitis obliterans (200×), (D–E) respiratory bronchiolitis-interstial lung disease/desquamative interstitial pneumonia(100×) and (F) adenocarcinoma with lepidic spread, previously bronchoalveolar cell carcinoma (100×). Power reported as original magnification.</p

Bronchoscopic cryoprobe and low power images of biopsies demonstrate cryobiopsies are larger than typical forceps biopsies.

<p>(A) Bronchoscopic cryoprobe. (B) Gross pathology of a representative cryobiopsy specimen measuring 19 mm in length. (C) Typical transbronchial forceps biopsy. (D)) Normal bronchoscopic cryobiopsy sample. All images were taken at low power (40×).</p

Distribution of diagnoses made by bronchoscopic cryobiopsy in 25 clinical subjects.

<p>Abbreviations: UIP/IPF, usual interstitial pneumonia/idiopathic pulmonary fibrosis; OP, organizing pneumonia; RBILD/DIP, respiratory bronchiolitis-interstitial lung disease/desquamative interstitial pneumonia; HP, hypersensitivity pneumonitis; CB, constrictive bronchiolitis.</p