Average growing season NDVI for 1982–2006.

<p>Average growing season NDVI for 1982–2006.</p

Vegetation areas for which the trend of NDVI in spring for 1982–2006 is significant at the 0.05 level and their trend slope.

<p>Vegetation areas for which the trend of NDVI in spring for 1982–2006 is significant at the 0.05 level and their trend slope.</p

Annual river flows at the Yingluo Gorge and Zhengyi Gorge for 1981–2006 and their trend lines.

<p>Annual river flows at the Yingluo Gorge and Zhengyi Gorge for 1981–2006 and their trend lines.</p

Land cover in the Heihe River Basin.

<p>Land cover in the Heihe River Basin.</p

Average annual precipitation for different periods at three meteorological stations (unit: mm).

<p>Average annual precipitation for different periods at three meteorological stations (unit: mm).</p

Vegetation areas for which the trend of NDVI in summer for 1982–2006 is significant at the 0.05 level and their trend slope.

<p>Vegetation areas for which the trend of NDVI in summer for 1982–2006 is significant at the 0.05 level and their trend slope.</p

Topography and river system of the Heihe River Basin.

<p>Topography and river system of the Heihe River Basin.</p

Pharmacokinetic parameters of xamoterol and STD-101-D1 determined in the 4-hr time-course study.

<p>Pharmacokinetic parameters of xamoterol and STD-101-D1 determined in the 4-hr time-course study.</p

Effects of structural modifications of the phenolic OH moiety of xamoterol on the cAMP pathway mediated by ADRB1.

<p>clogP^a, Calculated with ChemDraw Pro Version 16.0 (PerkinElmer Health Sciences, CT; EC₅₀ (nM)^b, Geometrical mean of EC50 values from at least two independent experiments; % Iso max^c, Percent efficacy compared to the maximum response achieved with isoproterenol; ~^d, Could not be determined.</p

Metabolic stability in mouse, rat, and human microsomes.

<p>STD-101-D1 and two reference compounds verapamil and propranolol were incubated at 0.1 uM in mouse (A), rat (B), or human (C) liver microsomes. Serial samples were removed up until 60 min. All experiments were performed in duplicate, and data are represented as mean ± S.E.M.</p