A new theory of triangular intuitionistic fuzzy sets to solve the two-sided matching problem

In view of the limitations of triangular intuitionistic fuzzy numbers (TIFNs) in value selection and application, the purpose of this paper is to redefine and demonstrate the algorithm, expectation function and distance measure of TIFNs, and to put forward a new theory of triangular intuitionistic fuzzy sets (TIFSs). The new theory of TIFSs is then applied to the field of two-sided matching decision-making. To solve the two-sided matching problem based on TIFSs, the agent behavior factors of both sides are calculated by this theory. On this basis, a multi-objective matching model under TIFS preference is constructed. Furthermore, the optimal matching scheme is obtained by transforming and solving the model according to the expected score, the linear weighting and the algorithm of “being as good as possible”. Finally, the practicability of the proposed two-sided matching method is verified by a transaction matching example. The novelty and key idea of the proposed method are as follows: (1) it combines the idea of closeness in TOPSIS method and the expected score in the new theory of TIFSs to measure the behavior factors of two-sided agents; (2) it builds a two-sided matching model considering the behavior factors under the preference of TIFSs; (3) according to the idea of “being as good as possible”, a novel algorithm for solving the two-sided matching model under TIFS preference is proposed. The major conclusion and advantage of this paper is that the obtained BM scheme using the proposed method can reflect agent behavior factors and maximize agents’ satisfaction as much as possible

Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains

Abstract Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantation in host brains under continuous immunosuppressive administration and whether immunosuppression can be withdrawn to mitigate side effects remain unclear. Human induced neural stem/progenitor cells (iNPCs) have shown long-term survival and efficient neuronal differentiation in primate brains. Here, we evaluate the immune responses in primate brains triggered by human grafts. The results show that the immune responses, including the evident activation of microglia and the strong infiltration of lymphocytes (both T- and B-cells), are caused by xenografts at 4 months post transplantation (p.t.), but significantly reduced at 8 months p.t. under continuous administration of immunosuppressant Cyclosporin A. However, early immunosuppressant withdrawal at 5 months p.t. results in severe immune responses at 10 months p.t. These results suggest that continuous long-term immunosuppression is required for suppressing immune responses to xenografts in primate brains

Selective and Efficient SnMOF@BiVO₄ Photoanode for Two-Electron Water Oxidation to Hydrogen Peroxide Production

Photoelectrochemical water oxidation may provide one of the solutions to hydrogen peroxide production, but the selectivity and efficiency of the two-electron process still need to be improved. Precise control of the composition and structure of the photoanode materials is essential. Herein, a SnMOF@BiVO4 photoanode was fabricated for two-electron water oxidation to H2O2 production. The PEC production rate of H2O2 at 1.5 VRHE reached 0.62 μmol/min·cm2 and the Faradaic efficiency (FE) reached 82.0%. Meanwhile, the photocurrent density of SnMOF@BiVO4 was 2.5 times higher than that of pristine BiVO4, which was attributed to the enhanced two-electron oxidation selectivity and the accelerated charge transfer ability. This work provides a universal strategy for the fabrication of photoanode materials applied for PEC water oxidation to synthesize H2O2

Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway

Abstract Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Chemoresistance leads to poor responses to conventional therapy in patients with osteosarcoma. The discovery of novel effective therapeutic targets and drugs is still the main focus of osteosarcoma research. Nuclear receptors (NRs) have shown substantial promise as novel therapeutic targets for various cancers. In the present study, we performed a drug screen using 29 chemicals that specifically target 17 NRs in several different human osteosarcoma and osteoblast cell lines. The retinoic acid receptor beta (RARb) antagonist LE135, peroxisome proliferator activated receptor gamma (PPARg) antagonist T0070907, liver X receptor (LXR) agonist T0901317 and Rev-Erba agonist SR9011 significantly inhibited the proliferation of malignant osteosarcoma cells (U2OS, HOS-MNNG and Saos-2 cells) but did not inhibit the growth of normal osteoblasts. The effects of these NR modulators on osteosarcoma cells occurred in a dose-dependent manner and were not observed in NR-knockout osteosarcoma cells. These NR modulators also significantly inhibited osteosarcoma growth in vivo and enhanced the antitumour effect of doxorubicin (DOX). Transcriptomic and immunoblotting results showed that these NR modulators may inhibit the growth of osteosarcoma cells by regulating the PI3K/AKT/mTOR and ERK/mTOR pathways. DDIT4, which blocks mTOR activation, was identified as one of the common downstream target genes of these NRs. DDIT4 knockout significantly attenuated the inhibitory effects of these NR modulators on osteosarcoma cell growth. Together, our results revealed that modulators of RARb, PPARg, LXRs and Rev-Erba inhibit osteosarcoma growth both in vitro and in vivo through the mTOR signaling pathway, suggesting that treatment with these NR modulators is a novel potential therapeutic strategy

The Preparation of Gen-NH2-MCM-41@SA Nanoparticles and Their Anti-Rotavirus Effects

Genistein (Gen), a kind of natural isoflavone drug monomer with poor water solubility and low oral absorption, was incorporated into oral nanoparticles with a new mesoporous carrier material, NH2-MCM-41, which was synthesized by copolycondensation. When the ratio of Gen to NH2-MCM-41 was 1:0.5, the maximum adsorption capacity of Gen was 13.15%, the maximum drug loading was 12.65%, and the particle size of the whole core–shell structure was in the range of 370 nm–390 nm. The particles were characterized by a Malvern particle size scanning machine, XRD, Fourier transform infrared spectroscopy, scanning electron microscopy, and nitrogen adsorption and desorption. Finally, Gen-NH2-MCM-41 was encapsulated by sodium alginate (SA), and the chimerism of this material, denoted as GEN-NH2-MCM-41@SA, was investigated. In vitro release experiments showed that, after 5 h in artificial colon fluid (pH = 8.0), the cumulative release reached 99.56%. In addition, its anti-rotavirus (RV) effect showed that the maximum inhibition rate was 62.24% at a concentration of 30 μM in RV-infected Caco-2 cells, and it significantly reduced the diarrhea rate and diarrhea index in an RV-infected-neonatal mice model at a dose of 0.3 mg/g, which was better than the results of Gen. Ultimately, Gen-NH2-MCM-41@SA was successfully prepared, which solves the problems of low solubility and poor absorption and provides an experimental basis for the application of Gen in the clinical treatment of RV infection

Densification and electrical conductivity of Fe and Mn‐doped Ce 0.83

Fe and Mn-doped Ce0.83Sm0.085Nd0.085O2-&(SNDC) powders are successfully synthesized by the simple and efficient solid-liquid method. The crystallinity and morphologies of the powders were characterized by X-ray diffractometer, Raman spectrum, and scanning electron microscopy. The effect of doping on sintering behavior, grain interior, and grain boundary conductivity are studied. The doping of Fe can effectively reduce the sintering temperature from 1450(o)C to 1250 degrees C and keep the same density. Compared with SNDC, 1 mol% Fe-doped SNDC (Fe-SNDC) sintered at 1250 degrees C shows a higher total conductivity of 2.13 x 10(-2)S center dot cm(-1)at 650 degrees C. Also, it exhibits that doping of Fe can increase the conductivity of grain interior and grain boundary simultaneously. The present work shows that the Fe-SNDC synthesized by solid-liquid method can be used as a potential electrolyte for intermediate-temperature solid oxide fuel cells