A transient solution for vesicle electrodeformation and relaxation

A transient analysis for vesicle deformation under DC electric fields is developed. The theory extends from a droplet model, with the additional consideration of a lipid membrane separating two fluids of arbitrary properties. For the latter, both a membrane-charging and a membrane-mechanical model are supplied. The vesicle is assumed to remain spheroidal in shape for all times. The main result is an ODE governing the evolution of the vesicle aspect ratio. The effects of initial membrane tension and pulse length are examined. The model prediction is extensively compared with experimental data, and is shown to accurately capture the system behavior in the regime of no or weak electroporation. More importantly, the comparison reveals that vesicle relaxation obeys a universal behavior regardless of the means of deformation. The process is governed by a single timescale that is a function of the vesicle initial radius, the fluid viscosity, and the initial membrane tension. This universal scaling law can be used to calculate membrane properties from experimental data

Nonperturbative photon qqˉq\bar{q} light front wave functions from a contact interaction model

We propose a method to calculate the $q\bar{q}$ light front wave functions (LFWFs) of photon at low-virtuality, i.e., the light front amplitude of $\gamma^*\rightarrow q\bar{q}$ at low $Q^2$, based on a light front projection approach. We exemplify this method using a contact interaction model within Dyson-Schwinger equations formalism and obtain the nonperturbative photon $q\bar{q}$ LFWFs. In this case, we find the nonperturbative effects are encoded in the enhanced quark mass and a dressing function of covariant quark-photon vertex, as compared to the leading order quantum electrodynamics photon $q\bar{q}$ LFWFs. We then use nonperturbative-effect modified photon $q\bar{q}$ LFWFs to study the inclusive deep inelastic scattering HERA data in the framework of the color dipole model. The results demonstrate that the theoretical description of data at low $Q^2$ can be significantly improved once the nonperturbative corrections are included in the photon LFWFs.Comment: 11 pages, 4 figure

Fe-based metallic glasses and dyes in fenton-like processes: Understanding their intrinsic correlation

Fe-based metallic glasses have been demonstrated as effective heterogeneous catalysts in Fenton-like processes for dye degradation. Yet, currently corresponding studies have limitations due to the limited study object (dyes) and the correlation between metallic glasses and dye pollutants in Fenton-like processes is still not comprehensively studied. Accordingly, this work intensively investigated the thermal catalytic behavior correlations between two Fe-based metallic glasses (Fe78Si9B13 and Fe73.5Si13.5B9Cu1Nb3) and eight different dyes. Results indicated a lower activation energy in the more active metallic glass and a dependence of the activation energy of Fe-based metallic glasses in dye solutions. In addition, a high H2O2 concentration led to a declined catalytic efficiency but a photo-enhanced Fenton-like process overcame this limitation at high concentration of H2O2 due to the decrease of pH and enhancement of irradiation. Furthermore, the average mineralization rates of Fe78Si9B13 and Fe73.5Si13.5B9Cu1Nb3 have been measured to be 42.7% and 12.6%, respectively, and the correlation between decolorization and mineralization revealed that a faster decolorization in a Fenton-like process contributed to a higher mineralization rate. This work provides an intrinsic viewpoint of the correlation between Fe-based metallic glasses and dyes in Fenton-like processes and holds the promise to further promote the industrial value of metallic glasses

Diversities of disability caused by lung cancer in the 66 Belt and Road initiative countries: a secondary analysis from the Global Burden of Disease Study 2019

ObjectivesDue to the increase in life expectancy and the aging of the global population, the “Belt and Road” (“B&R”) countries are faced with varying degrees of lung cancer threat. The purpose of this study is to analyze the differences in the burden and trend of lung cancer disability in the “B&R” countries from 1990 to 2019 so as to provide an analytical strategic basis to build a healthy “B&R”.MethodsData were derived from the Global Burden of Disease 2019 (GBD 2019). Incidence, mortality, prevalence, the years lived with disability (YLDs), and disability-adjusted life years (DALYs) of lung cancer and those attributable to different risk factors were measured from 1990 to 2019. Trends of disease burden were estimated by using the average annual percent change (AAPC), and the 95% uncertainty interval (UI) was reported.ResultsChina, India, and the Russian Federation were the three countries with the highest burden of lung cancer in 2019. From 1990 to 2019, the AAPC of incidence, prevalence, mortality, and DALYs generally showed a downward trend in Central Asia (except Georgia) and Eastern Europe, while in China, South Asia (except Bangladesh), most countries in North Africa, and the Middle East, the trend was mainly upward. The AAPC of age-standardized incidence was 1.33% (1.15%–1.50%); the AAPC of prevalence, mortality, and DALYs from lung cancer in China increased by 24% (2.10%–2.38%), 0.94% (0.74%–1.14%), and 0.42% (0.25%–0.59%), respectively. A downward trend of the AAPC values of age-standardized YLD rate in men was shown in the vast majority of “B&R” countries, but for women, most countries had an upward trend. For adults aged 75 years or older, the age-standardized YLD rate showed an increasing trend in most of the “B&R” countries. Except for the DALY rate of lung cancer attributable to metabolic risks, a downward trend of the DALY rate attributable to all risk factors, behavioral risks, and environmental/occupational risks was shown in the vast majority of “B&R” countries.ConclusionThe burden of lung cancer in “B&R” countries varied significantly between regions, genders, and risk factors. Strengthening health cooperation among the “B&R” countries will help to jointly build a community with a shared future for mankind

Identification and verification of a prognostic signature based on a miRNA–mRNA interaction pattern in colon adenocarcinoma

The expression characteristics of non-coding RNA (ncRNA) in colon adenocarcinoma (COAD) are involved in regulating various biological processes. To achieve these functions, ncRNA and a member of the Argonaute protein family form an RNA-induced silencing complex (RISC). The RISC is directed by ncRNA, especially microRNA (miRNA), to bind the target complementary mRNAs and regulate their expression by interfering with mRNA cleavage, degradation, or translation. However, how to identify potential miRNA biomarkers and therapeutic targets remains unclear. Here, we performed differential gene screening based on The Cancer Genome Atlas dataset and annotated meaningful differential genes to enrich related biological processes and regulatory cancer pathways. According to the overlap between the screened differential mRNAs and differential miRNAs, a prognosis model based on a least absolute shrinkage and selection operator-based Cox proportional hazards regression analysis can be established to obtain better prognosis characteristics. To further explore the therapeutic potential of miRNA as a target of mRNA intervention, we conducted an immunohistochemical analysis and evaluated the expression level in the tissue microarray of 100 colorectal cancer patients. The results demonstrated that the expression level of POU4F1, DNASE1L2, and WDR72 in the signature was significantly upregulated in COAD and correlated with poor prognosis. Establishing a prognostic signature based on miRNA target genes will help elucidate the molecular pathogenesis of COAD and provide novel potential targets for RNA therapy

Effect of deviation of welding parameters on mechanical properties of X80 steel girth weld

Tensile tests were carried out on X80 steel girth welds with four different parameters (no deviation of welding parameters, inadequate number of welding layers, inadequate preheating temperature and inadequate interpass temperature) under automatic welding technology. The strain distribution behavior, strain hardening law and the influence of welding parameter deviation on mechanical properties were studied during tensile deformation. The results show that the strain localization occurs at the interface of the weld filler layer when the preheating temperature of the weld is inadequate and the interpass temperature of the weld is inadequate, and the strain localization occurs at the maximum thickness of the filler layer when the number of welding layers is inadequate. The deviation of welding parameters significantly reduces the strength of girth weld. The yield strength and tensile strength are the lowest when the interpass temperature is inadequate. When the interpass temperature is inadequate, the strain hardening ability deteriorates rapidly. When there is no deviation of welding parameters, the fracture is dimple shaped, which is typical ductile fracture. When the welding parameters deviate, the fracture of the girth weld is a mixed fracture of toughness and brittleness; When the number of welding layers is inadequate, it is mainly brittle fracture; When preheating temperature and interpass temperature are inadequate, ductile fracture is the main mechanism