Three-body molecules DˉDˉ∗Σc\bar{D}\bar{D}^{\ast}\Sigma_{c}- understanding the nature of TccT_{cc}, Pc(4312)P_{c}(4312), Pc(4440)P_{c}(4440) and Pc(4457)P_{c}(4457)

The nature of the three pentaquark states, $P_{c}(4312)$, $P_{c}(4440)$ and $P_{c}(4457)$, discovered by the LHCb Collaboration in 2019, is still under debate, although the $\bar{D}^{(\ast)}\Sigma_{c}$ molecular interpretation seems to be the most popular. In this work, by adding a $\bar{D}$ meson into the $\bar{D}^{\ast}\Sigma_{c}$ pair, we investigate the mass and decay width of the three-body molecules $\bar{D}\bar{D}^{\ast}\Sigma_{c}$ and explore the correlation between the existence of the $\bar{D}\bar{D}^{\ast}\Sigma_{c}$ molecules with the existence of $\bar{D}^{(\ast)}\Sigma_{c}$ and $\bar{D}^{\ast}\bar{D}$ two-body molecules. The latter can be identified with the doubly charmed tetraquark state $T_{cc}$ recently discovered by the LHCb Collaboration. Based on the molecular nature of $P_{c}(4312)$, $P_{c}(4440)$, $P_{c}(4457)$, and $T_{cc}$, our results indicate that there exist two three-body bound states of $\bar{D}\bar{D}^{\ast}\Sigma_{c}$ with $I(J^{P})=1(1/2^{+})$ and $I(J^{P})=1(3/2^{+})$, and binding energies $37.24$ MeV and $29.63$ MeV below the $\bar{D}\bar{D}^{\ast}\Sigma_{c}$ mass threshold. In addition, we find that the mass splitting of these two three-body molecules are correlated to the mass splitting of $P_{c}(4440)$ and $P_{c}(4457)$, which offers a non-trivial way to reveal the molecular nature of these states. The partial widths of two $\bar{D}\bar{D}^{\ast}\Sigma_{c}$ molecules decaying into $J/\psi p \bar{D}$ and $J/\psi p \bar{D}^{\ast}$ are found to be several MeV. We recommend the experimental searches for the $\bar{D}\bar{D}^{\ast}\Sigma_{c}$ molecules in the $J/\psi p \bar{D}$ and $J/\psi p \bar{D}^{\ast}$ invariant mass distributions

Effects of low-molecular-weight heparin and unfractionated heparin on traumatic disseminated intravascular coagulation

Purpose: To explore the effects of unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) on traumatic disseminated  intravascular coagulation (DIC).Methods: A total of 77 cases of severe trauma (APACHE II score: 5 – 10) with DIC were collected and randomly assigned to one of three groups: LMWH treatment - 26 cases were subcutaneously injected with LMWH (75–150 units/kg/d); UFH treatment - 25 cases were subcutaneously  injected with UFH (100 – 250 units/kg/d); control - 26 cases supplemented with blood coagulation factor only. Daily mortality in the intensive care unit (ICU), hospitalization time, bleeding rate, thrombin time, prothrombin time, activated partial thromboplastin time, and levels of fibrinogen, antithrombin III (ATIII), and D-dimer were recorded and analyzed.Results: In ICU, LMWH and UFH treatments resulted in lower mortality than in the control group. In addition, hospitalization time was longer in patients treated with LMWH and UFH than in control patients. No significant  differences were found between LMWH-treated and control patients in terms of bleeding rate, but UFH-treated patients had lower bleeding rates than control patients. Multifactor analysis indicate a strong relationship between ATIII levels and bleeding rate.Conclusion: The results indicate that low-dose UFH and LMWH are effective options for the treatment of DIC.Keywords: Trauma, Disseminated intravascular coagulation, Unfractionated heparin, Low-molecularweight heparin, Fibrinogen, Antithrombi

Cavernous Transformation of the Portal Vein Might Increase the Risk of Liver Abscess

Cavernous transformation of the portal vein (CTPV) is not quite common in adults, and cases with CTPV and acute liver abscess are lacking. We report a patient with CTPV inducing extrahepatic and intrahepatic obstruction, finally leading to acute liver abscess due to bile duct infection. We aim to find out the possible relationship between CTPV and acute liver abscess. A 45-year-old female patient was admitted to our hospital for recurrent upper abdominal pain and distension for one year, aggravated with fever for three years. A diagnosis of CTPV and liver abscess was made by 16-slice computed tomography. Effective antibiotics and drainage were used for this patients, and she was eventually cured. When treating patients with CTPV, extrahepatic and intrahepatic obstruction, one should be aware of the presence of acute liver abscess, and empirical antibiotics might be valuable

Association between TGFBR1*6A and osteosarcoma: A Chinese case-control study

<p>Abstract</p> <p>Background</p> <p>TGFBR1*6A is a common hypomorphic variant of transforming growth factor β receptor 1 (TGFBR1). TGFBR1*6A is associated with an increased cancer risk, but the association of this polymorphism with osteosarcoma remains unknown. We have measured the frequency of TGFBR1*6A variants in osteosarcoma cases and controls.</p> <p>Methods</p> <p>Our case-control study is based on 168 osteosarcoma patients and 168 age- and gender-matched controls. Blood samples were obtained and the TGFBR1*6A variant determined by PCR amplification and DNA sequencing. The odds ratio (OR) and 95% confidence interval (95% CI) for the TGFBR1*6A polymorphism were calculated by unconditional logistic regression, adjusted for both age and gender. Three models - dominant, additive and recessive - were used to analyze the contribution of the TGFBR1*6A variant to osteosarcoma susceptibility.</p> <p>Results</p> <p>Heterozygotic and homozygotic TGFBR1*6A variants represented 50.4% and 6.0% of the 168 cases, whereas the controls had 18. 5% and 1.3%, respectively. ORs for homozygosity and heterozygosity of the TGFBR1*6A allele were 4.6 [95% CI, 2.33-7.97] and 2.9 [95% CI, 1.59-5.34] in the additive model. There were significant increases in the TGFBR1*6A variants in osteosarcoma cases compared to control in all 3 models. Further analysis showed that TGFBR1*6A genotypes were not associated with gender, age, or tumor location. However, TGFBR1*6A was significantly associated with less metastasis.</p> <p>Conclusions</p> <p>TGFBR1*6A, a dominant polymorphism of TGFBR1, is associated with increased susceptibility and metastasis spread of osteosarcoma.</p

Development of a Portable Electronic Nose System for the Detection and Classification of Fruity Odors

In this study, we have developed a prototype of a portable electronic nose (E-Nose) comprising a sensor array of eight commercially available sensors, a data acquisition interface PCB, and a microprocessor. Verification software was developed to verify system functions. Experimental results indicate that the proposed system prototype is able to identify the fragrance of three fruits, namely lemon, banana, and litchi