The shackles of gender still exist: Chinese women authors’ consciousness in boys’ love fiction

Boys’ love (BL) fiction has flourished in China since the beginning of the twenty-first century. It primarily focuses on the romance between men, while most authors and readers of BL fiction are heterosexual women; thus it is paradoxically patriarchal and feminist. This study aims to explore two main questions: (1) What topics do Chinese BL fiction authors prefer? (2) How do the gender concepts of Chinese culture affect the topics and contents of BL fiction? Adopting machine learning methods––the Latent Dirichlet Allocation (LDA) topic model and word vector technology—this study presents the typical topics and specific contents of 72,548 original BL fiction pieces from synchronic and diachronic dimensions. The findings reveal that Chinese BL fiction extensively uses Chinese myths and history to create heterosexually structured fantasies. Furthermore, under the Chinese patriarchal culture, primarily the clan concept, BL authors attach great importance to marriage and reproduction issues. Such discourses eventually limit Chinese BL women authors’ awakening of a feminist consciousness

Relativistic Correction to J/\psi Production at Hadron Colliders

Relativistic corrections to the color-singlet J/\psi hadroproduction at the Tevatron and LHC are calculated up to O(v^2) in nonrelativistic QCD (NRQCD). The short distance coefficients are obtained by matching full QCD with NRQCD results for the subprocess g+g\to J/\psi+g. The long distance matrix elements are extracted from observed J/\psi hadronic and leptonic decay widths up to O}(v^2). Using the CTEQ6 parton distribution functions, we calculate the LO production cross sections and relativistic corrections for the process p+\bar{p}(p)\to J/\psi+X at the Tevatron and LHC. We find that the enhancement of O(v^2) relativistic corrections to the cross sections over a wide range of large transverse momentum p_t is negligible, only at a level of about 1 %. This tiny effect is due to the smallness of the correction to short distance coefficients and the suppression from long distance matrix elements. These results indicate that relativistic corrections can not help to resolve the large discrepancy between leading order prediction and experimental data for J/\psi production at the Tevatron.Comment: 9 pages, 5 figure

Invasive reperfusion after 12 hours of the symptom onset remains beneficial in patients with ST-segment elevation myocardial infarction: Evidence from a meta-analysis of published data

Background: Early myocardial reperfusion therapy (< 12 h) in patients with acute myocardial infarc­tion (AMI) can significantly improve their prognosis. However, the effect of late reperfusion (> 12 h) remains controversial. In this study, the effects of late reperfusion versus standard drug therapy on the outcomes of patients with AMI were evaluated by systematic review and meta-analysis. Methods: PubMed, Embase, Medline, Cochrane, Wanfang, and CNKI databases were searched for eligible studies for the present study. Meta-analysis was performed using RevMan 5.3.3 software. Rela­tive risk (RR) and the 95% confidence interval (CI) were used to compare the outcomes between the two groups. The main outcome measures were major adverse cardiac events (MACEs), all-cause mortality, recurrent myocardial infarction (MI), and heart failure. Results: Eighteen studies were identified including 14,677 patients, of whom 5157 received late reperfusion with percutaneous coronary intervention (PCI) and 9520 received medication therapy (MT). Compared to MT, late PCI was associated with decreased all-cause mortality (RR 0.60, 95% CI 0.44–0.83; p = 0.002), MACEs (RR 0.67; 95% CI 0.50–0.89; p < 0.001), and heart failure (RR 0.76; 95% CI 0.60–0.97; p = 0.03), while there was also a trend toward decreased recurrent MI (RR 0.70; 95% CI 0.47–1.05; p = 0.08). However, subgroup analysis according to time to PCI showed that the clinical benefit was only from PCI after 12 h but not from 2 to 60 days of the onset of symptoms. Conclusions: The present meta-analysis suggested that PCI performed > 12 h but not 2–60 days after AMI is associated with significant improvement in clinical outcomes. However, these results need further rigorously designed large sample size clinical trials to be validated

Validation of the rupture properties of the 2001 Kunlun, China (M_s=8.1), earthquake from seismological and geological observations

We determine the finite-fault slip distribution of the 2001 Kunlun earthquake (M_s = 8.1) by inverting teleseismic waveforms, as constrained by geological and remote sensing field observations. The spatial slip distribution along the 400-km-long fault was divided into five segments in accordance with geological observations. Forward modelling of regional surface waves was performed to estimate the variation of the speed of rupture propagation during faulting. For our modelling, the regional 1-D velocity structure was carefully constructed for each of six regional seismic stations using three events with magnitudes of 5.1–5.4 distributed along the ruptured portion of the Kunlun fault. Our result shows that the average rupture velocity is about 3.6 km s^−1, consistent with teleseismic long period wave modelling. The initial rupture was almost purely strike-slip with a rupture velocity of 1.9 km s^−1, increasing to 3.5 km s^−1 in the second fault segment, and reaching a rupture velocity of about 6 km s^−1 in the third segment and the fourth segment, where the maximum surface offset, with a broad fault zone, was observed. The rupture velocity decelerated to a value of 3.3 km s^−1 in the fifth and final segment. Coseismic slip on the fault was concentrated between the surface and a depth of about 10 km. We infer that significant variations in rupture velocity and the observed fault segmentation are indicative of variations in strength along the interface of the Kunlun fault, as well as variations in fault geometry

Comparative Proteomics Study on Human High-metastatic Large Cell Lung Cancer Cell Lines Before and After Transfecting with nm23-H1 Gene

Background and objective As a tumor metastasis suppressor gene, the functions of nm23-H1 gene are still unclear. The aim of this study is to better understand the mechanism of lung cancer metastasis and to find new biomarkers for early diagnosis and new target for therapy by conducting comparative proteomics between the human high-metastatic large cell lung cancer cell lines (L9981) and L9981-nm23-H1 (constructed with transfecting nm23-H1 gene into the L9981 cell line). Methods The total proteins of L9981 and L9981-nm23-H1 were separated by immobilized pH gradient (IPG)-based 2-dimensional electrophoresis (2-DE); the significantly differently expressed proteins were examined by mass spectrometry and analyzed by bioinformatics. Results It was observed that nm23-H1 gene transfection caused remarkable changes of the proteome of L9981 compared with L9981-nm23-H1 cells: 5 proteins were deleted, 9 proteins appeared, 16 proteins downregulated, and 12 proteins up-regulated. These proteins are involved in cell framework, signal transduction, metabolism, proliferation and metastasis. Conclusion After nm23-H1 gene is transfected into L9981, proteome in L9981 is remarkably changed. These changes of the proteome could serve as a basis for reversing the invasive and metastatic phenotype in lung cancer and elucidating the machanisms of the metastasis of lung cancer

Attenuating effect of pretreatment with Yiqifumai on lipopolysaccharide-induced intestine injury and survival rate in rat

<p>Abstract</p> <p>Background</p> <p>Yiqifumai is a traditional Chinese medicine compound preparation used for treatment of microcirculatory disturbance-related diseases in China. We have previous reported that pretreatment with Yiqifumai could improve the lipopolysaccharide (LPS) -induced microcirculatory disturbance in rat mesentery. The present study intended to investigate the effect of pretreatment with Yiqifumai on intestine injury and survival rate of the rats subjected to LPS challenge.</p> <p>Methods</p> <p>Male Wistar rats were continuously infused with LPS (5 mg kg^-1body weight h^-1) via the left jugular vein for 90 min. In some rats, Yiqifumai 80 (mg/kg) was administrated through the left jugular vein 10 min before LPS infusion. The mean arterial pressure (MAP), heart rate (HR), rectal temperature (RT), respiratory rate (RR) and survival rate were measured at 24 h, 48 h and 72 h after LPS infusion. At 72 h after exposure to LPS, the intestine morphology was observed under a stereomicroscope and the immunohistochemistry staining of intestine was conducted to evaluate the expression of intercellular adhesion molecule 1 (ICAM-1) and the number of myeloperoxidase (MPO) positive cells in tissue. After observation of intestine microcirculation, blood was collected from the abdominal aorta of each animal to analyze the level of inflammatory markers in plasma, including TNF-α and MCP-1.</p> <p>Results</p> <p>Compared to the control, LPS infusion significantly decreased MAP and the survival rate and increased the HR, RT and RR, as well as elicited leukocyte infiltration, intestine hemorrhage, enhanced expression of ICAM-1 and raised level of inflammatory markers. All of indicators, except for the RT, were significantly attenuated by Yiqifumai, in contrast to the LPS group.</p> <p>Conclusions</p> <p>The results demonstrated the potential of pretreatment with Yiqifumai to ameliorate rat intestine injury, inflammatory response to LPS and the decrease in survival rate caused by LPS challenge.</p

Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos

<p>Abstract</p> <p>Background</p> <p>Patterning along the anterior-posterior (A-P) axis in <it>Drosophila </it>embryos is instructed by the morphogen gradient of Bicoid (Bcd). Despite extensive studies of this morphogen, how embryo geometry may affect gradient formation and target responses has not been investigated experimentally.</p> <p>Results</p> <p>In this report, we systematically compare the Bcd gradient profiles and its target expression patterns on the dorsal and ventral sides of the embryo. Our results support a hypothesis that proper distance measurement and the encoded positional information of the Bcd gradient are along the perimeter of the embryo. Our results also reveal that the dorsal and ventral sides of the embryo have a fundamentally similar relationship between Bcd and its target Hunchback (Hb), suggesting that Hb expression properties on the two sides of the embryo can be directly traced to Bcd gradient properties. Our 3-D simulation studies show that a curvature difference between the two sides of an embryo is sufficient to generate Bcd gradient properties that are consistent with experimental observations.</p> <p>Conclusions</p> <p>The findings described in this report provide a first quantitative, experimental evaluation of embryo geometry on Bcd gradient formation and target responses. They demonstrate that the physical features of an embryo, such as its shape, are integral to how pattern is formed.</p