5 research outputs found
A Retrospective Review of the Prognostic Value of ALDH-1, Bmi-1 and Nanog Stem Cell Markers in Esophageal Squamous Cell Carcinoma
<div><p>Stem cell markers are upregulated in various cancers and have potential as prognostic indicators. The objective of this study was to determine the expression of three stem cell markers, aldehyde dehydrogenase 1 (ALDH-1), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1), and Nanog, in esophageal squamous cell carcinoma (ESCC) tissues. Immunohistochemistry was used to measure the expression of ALDH-1, Bmi-1, and Nanog in ESCC tissues from 41 patients who received pre-operative chemoradiation. We evaluated the relationship between expression of these markers, and clinicopathological features, tumor regression grade (TRG), and 5-year overall survival (OS). There were no significant associations of ALDH-1 or Bmi-1 expression with age, gender, clinical stage, and treatments (<i>p</i>>0.05). However, patients with Nanog-positive tumors were significantly older than those whose tumors were Nanog-negative (<i>p</i> = 0.033). TRG after treatment was significantly associated with expression of ALDH-1 (<i>p</i> = 0.001), Bmi-1 (<i>p</i> = 0.004), and Nanog (<i>p</i><0.001). Although OS was significantly better in patients with low TRGs (<i>p</i> = 0.001), there were no significant correlations between ALDH-1, Bmi-1, or Nanog with OS. Expression of ALDH-1, Bmi-1, and Nanog correlated with TRG, but not OS. Further large studies are necessary to fully elucidate the prognostic value of these stem cell markers for ESCC patients.</p></div
Representative images of cancer stem cell markers (top: ALDH1, middle: Bmi-1, bottom: Nanog) with different stain intensities (weak, moderate, strong).
<p>Representative images of cancer stem cell markers (top: ALDH1, middle: Bmi-1, bottom: Nanog) with different stain intensities (weak, moderate, strong).</p
Relationship between expression of stem cell markers and characteristics of 41 patients with ESCC.
<p>Each number indicates median and interquartile range unless otherwise specified.</p><p><i>P</i>-values are based on <sup>1</sup>Mann-Whitney U test and <sup>2</sup>Fisher's exact test.</p
Relationship of expression of cancer stem cell markers (A: ALDH-1, B: Bmi-1, C: Nanog) with tumor regression grade.
<p><sup>*</sup><i>P</i><0.01.</p