A Solution to the Problem of “Credit Discrimination against SME”: From Cross Organization Information Sharing of G2B E-government

To solve the problem of Credit Discrimination against SME , firstly the relevant literature concerning the approaches to the problem is reviewed and deficiencies are pointed out. Then the role of government and the mode of credit information sharing in foreign countries are analyzed, which can be valued as the practice basis of E-government services design. Finally, on the basis of policies and regulations and actual situation in China and theoretical analysis, the paper constructed the value of cross-organizational information sharing service value network and services model, and designed E-government service system in SME lending decisions and supervision, as a new perspective to solve the problem of the discrimination. This study provides a reference for developing countries that have a similar problem of Credit Discrimination against SME and same conditions of credit information

Tissue specific induction of p62/sqstm1 by farnesoid X receptor

Background: Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis. FXR is protective against carcinogenesis and inflammation in liver and intestine as demonstrated by the development of inflammation and tumors in the liver and intestine of FXR knock-out mice. However, mechanisms for the protective effects of FXR are not completely understood. This study reports a novel role of FXR in regulating expression of Sqstm1, which encodes for p62 protein. p62 plays an important role in maintaining cellular homeostasis through selective autophagy and activating signal transduction pathways, such as NF-κB to support cell survival and caspase-8 to initiate apoptosis. FXR regulation of Sqstm1 may serve as a protective mechanism. Methods and Results: This study showed that FXR bound to the Sqstm1 gene in both mouse livers and ileums as determined by chromatin immunoprecipitation. In addition, FXR activation enhanced transcriptional activation of Sqstm1 in vitro. However, wild-type mice treated with GW4064, a synthetic FXR ligand, showed that FXR activation induced mRNA and protein expression of Sqstm1/p62 in ileum, but not in liver. Interestingly, FXR-transgenic mice showed induced mRNA expression of Sqstm1 in both liver and ileum compared to wild-type mice. Conclusions: Our current study has identified a novel role of FXR in regulating the expression of p62, a key factor in protein degradation and cell signaling. Regulation of p62 by FXR indicates tissue-specific and gene-dosage effects. Furthermore, FXR-mediated induction of p62 may implicate a protective mechanism of FXR. © 2012 Williams et al

Polymorphism in exon 1 of adiponectin gene and its association with water holding capacity, IMF and abdominal fat in duck

The objective of the present study was to investigate the effect of polymorphism in adiponectin gene on meat quality traits, serum total cholesterol, serum triglyceride and abdominal fat of 170 individuals from Cherry Valley duck (CV), Jinding duck (JD) and Hybrid duck (CV × JD) (HB) populations. PCR-SSCP technique was developed to analyze a 230 bp region of the adiponectin gene exon 1. Three genotypes (CC, CD and DD), which were the products of two alleles (C and D) were observed. Alignment sequences’ results showed that four SNPs (C86T, C104T, C146T and C155T) were found and all of those nucleotide variations were nonsense mutations. Association analysis indicated that all of these traits had significant population effects except meat colour (P < 0.05) and then the birds with homozygote (CC) had significant lower than homozygotes (DD) for IMF, water holding capacity and abdominal fat (P < 0.05). The research suggested that genotype DD may be an advantage genotype for fat deposition in duck. The adiponectin gene exon 1 polymorphism could be used in marker assistant selection (MAS) as a genetic marker for the birds’ fat deposition.Key words: Duck, adiponectin gene, polymorphism, meat quality, fatness

The Study of the Composite Material Go/CF/PTFE Tribological Property

In this paper, the composite material Go/CF/PTFE tribological property was studied. The test of its mechanical property, and the fabrication of the filled PTEE composite material sample which is based on the technology of cold press molding and sinter molding proved that adding Go and CF moderately to the composite material was an efficient way to improve its mechanical property. Meanwhile the process of friction and wear trial and SEM analysis results of the micro-structure of wear pattern proved that the addition of the Go and CF tremendously improved the anti-wear property and that after the addition the plowing effect which took place on the material surface would turn into a kind of mixed wear effect that includes plowing effect and fatigue wear. Working as pinning and bridging, the Go which distributing uniformly in the matrix was able to improve the resistance and substantially resisted the crack propagation, therefore to a certain degree enhanced the intensity of composite material and prolong its lifespan