14,027 research outputs found
Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease
Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects. Using washed membrane homogenates from the frontal cortex, hippocampus, caudate nucleus, and putamen, saturation analysis of specific receptor binding was performed for the total number of muscarinic receptors with [3H]quinuclidinyl benzilate, for muscarinic M1 receptors with [3H]pirenzepine, for muscarinic M2 receptors with [3H]oxotremorine-M, and for nicotinic receptors with (-)-[3H]nicotine. In comparison with control tissues, choline acetyl-transferase activity was reduced in the frontal cortex and hippocampus and unchanged in the caudate nucleus and putamen of parkinsonian patients. In Parkinson's disease the maximal binding site density for [3H]quinuclidinyl benzilate was increased in the frontal cortex and unaltered in the hippocampus, caudate nucleus, and putamen. Specific [3H]pirenzepine binding was increased in the frontal cortex, unaltered in the hippocampus, and decreased in the caudate nucleus and putamen. In parkinsonian patients Bmax values for specific [3H]oxotremorine-M binding were reduced in the cortex and unchanged in the hippocampus and striatum compared with controls. Maximal (-)-[3H]nicotine binding was reduced in both the cortex and hippocampus and unaltered in both the caudate nucleus and putamen. Alterations of the equilibrium dissociation constant were not observed for any ligand in any of the brain areas examined. The present results suggest that both the innominatocortical and the septohippocampal cholinergic systems degenerate in Parkinson's disease.(ABSTRACT TRUNCATED AT 250 WORDS
Method of fan sound mode structure determination
A method for the determination of fan sound mode structure in the Inlet of turbofan engines using in-duct acoustic pressure measurements is presented. The method is based on the simultaneous solution of a set of equations whose unknowns are modal amplitude and phase. A computer program for the solution of the equation set was developed. An additional computer program was developed which calculates microphone locations the use of which results in an equation set that does not give rise to numerical instabilities. In addition to the development of a method for determination of coherent modal structure, experimental and analytical approaches are developed for the determination of the amplitude frequency spectrum of randomly generated sound models for use in narrow annulus ducts. Two approaches are defined: one based on the use of cross-spectral techniques and the other based on the use of an array of microphones
A magnetically rotated electric arc air heater employing a strong magnetic field and copper electrodes
Magnetically rotated electric arc air heater using strong magnetic field and copper electrode
Evidence of sympathetic cooling of Na+ ions by a Na MOT in a hybrid trap
A hybrid ion-neutral trap provides an ideal system to study collisional
dynamics between ions and neutrals. This system provides a general cooling
method that can be applied to optically inaccessible species and can also
potentially cool internal degrees of freedom. The long range polarization
potentials () between ions and neutrals result in large
scattering cross sections at cold temperatures, making the hybrid trap a
favorable system for efficient sympathetic cooling of ions by collisions with
neutral atoms. We present experimental evidence of sympathetic cooling in a
hybrid trap of \ce{Na+} ions, which are closed shell and therefore do not have
a laser induced atomic transition, by equal mass cold Na atoms in a
magneto-optical trap (MOT).Comment: 7 figure
Ion-neutral sympathetic cooling in a hybrid linear rf Paul and magneto-optical trap
Long range polarization forces between ions and neutral atoms result in large
elastic scattering cross sections, e.g., 10^6 a.u. for Na+ on Na or Ca+ on Na
at cold and ultracold temperatures. This suggests that a hybrid ion-neutral
trap should offer a general means for significant sympathetic cooling of atomic
or molecular ions. We present SIMION 7.0 simulation results concerning the
advantages and limitations of sympathetic cooling within a hybrid trap
apparatus, consisting of a linear rf Paul trap concentric with a Na
magneto-optical trap (MOT). This paper explores the impact of various heating
mechanisms on the hybrid system and how parameters related to the MOT, Paul
trap, number of ions, and ion species affect the efficiency of the sympathetic
cooling
Flux-Confinement in Dilatonic Cosmic Strings
We study dilaton-electrodynamics in flat spacetime and exhibit a set of
global cosmic string like solutions in which the magnetic flux is confined.
These solutions continue to exist for a small enough dilaton mass but cease to
do so above a critcal value depending on the magnetic flux. There also exist
domain wall and Dirac monopole solutions. We discuss a mechanism whereby
magnetic monopolesmight have been confined by dilaton cosmic strings during an
epoch in the early universe during which the dilaton was massless.Comment: 8 pages, DAMTP R93/3
Model-independent measurements of the sodium magneto-optical trap's excited-state population
We present model-independent measurements of the excited-state population of
atoms in a sodium (Na) magneto-optical trap (MOT) using a hybrid ion-neutral
trap composed of a MOT and a linear Paul trap (LPT). We photoionize excited Na
atoms trapped in the MOT and use two independent methods to measure the
resulting ions: directly by trapping them in our LPT, and indirectly by
monitoring changes in MOT fluorescence. By measuring the ionization rate via
these two independent methods, we have enough information to directly determine
the population of MOT atoms in the excited-state. The resulting measurement
reveals that there is a range of trapping-laser intensities where the
excited-state population of atoms in our MOT follows the standard two-level
model intensity-dependence. However, an experimentally determined effective
saturation intensity must be used instead of the theoretically predicted value
from the two-level model. We measured the effective saturation intensity to be
for the type-I Na MOT and
for the type-II Na MOT,
approximately 1.7 and 3.6 times the theoretical estimate, respectively. Lastly,
at large trapping-laser intensities, our experiment reveals a clear departure
from the two-level model at a critical intensity that we believe is due to a
state-mixing effect, whose critical intensity can be determined by a simple
power broadening model.Comment: 10 pages, 8 figure
Rigidity analysis of HIV-1 protease
We present a rigidity analysis on a large number of X-ray crystal structures
of the enzyme HIV-1 protease using the 'pebble game' algorithm of the software
FIRST. We find that although the rigidity profile remains similar across a
comprehensive set of high resolution structures, the profile changes
significantly in the presence of an inhibitor. Our study shows that the action
of the inhibitors is to restrict the flexibility of the beta-hairpin flaps
which allow access to the active site. The results are discussed in the context
of full molecular dynamics simulations as well as data from NMR experiments.Comment: 4 pages, 3 figures. Conference proceedings for CMMP conference 2010
which was held at the University of Warwic
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