Apparatus for ejection of an instrument cover

Apparatus for ejecting covers of instrument packages using differential pressure principl

Production of CO(a 3 Pi) and other metastable fragments by electron impact dissociation of CO2

Dissociative excitation of CO(a 3 Pi) and other metastable fragments such as O(5S) produced by electron impact on CO

Excitation of the metastable E(3 Sigma g plus) state of N2 by electron impact

The contribution of the N2(E(3 Sigma g plus)) state to the total metastable excitation function of N2 assessed on the basis of time-of-flight studies of metastable nitrogen molecules. The cross section for electron impact excitation state was determined in the domain of the resonance form threshold (11.87 eV) to an energy of about 13 eV. The maximum value of the cross section was found to be (7.0 + or - 4.0) x 10 to the -18th power sq cm at an energy of 12.2 eV. The measurement was made absolute by using the previously determined yield of the metastable detector, the lifetime of the E state, and by eliminating the energy spread in the electron beam from the raw data. The half-width (FWHM) of the resonance-like excitation function near threshold was found to be about 0.4 eV. No substantial evidence was obtained from the present data for the presence of the nonresonant part of the excitation function for the state studied

Investigating synthetic oligonucleotide targeting of miR31 in Duchenne muscular dystrophy

Exon-skipping via synthetic antisense oligonucleotides represents one of the most promising potential therapies for Duchenne muscular dystrophy (DMD), yet this approach is highly sequence-specific and thus each oligonucleotide is of benefit to only a subset of patients. The discovery that dystrophin mRNA is subject to translational suppression by the microRNA miR31, and that miR31 is elevated in the muscle of DMD patients, raises the possibility that the same oligonucleotide chemistries employed for exon skipping could be directed toward relieving this translational block. This approach would act synergistically with exon skipping where possible, but by targeting the 3’UTR it would further be of benefit to the many DMD patients who express low levels of in-frame transcript. We here present investigations into the feasibility of combining exon skipping with several different strategies for miR31-modulation, using both in vitro models and the mdx mouse (the classical animal model of DMD), and monitoring effects on dystrophin at the transcriptional and translational level. We show that despite promising results from our cell culture model, our in vivo data failed to demonstrate similarly reproducible enhancement of dystrophin translation, suggesting that miR31-modulation may not be practical under current oligonucleotide approaches. Possible explanations for this disappointing outcome are discussed, along with suggestions for future investigations

Saturn orbiter mission study

A preliminary analysis of the important aspects of missions orbiting the planet Saturn is provided. Orbital missions to Saturn is given serious consideration for the 1980's, or after flybys by Pioneer 10/G and Mariner Jupiter-Saturn 1977. An attempt is made to characterize Saturn orbiters in detail so that comparisons with Jupiter missions can be made. The scientific objectives of Saturn exploration are grouped under four topics: (1) the atmosphere, (2) the magnetosphere, (3) the rings, and (4) the satellites

Airborne observations of methane in Comet Kohoutek

The experiment is described for airborne observations of Comet Kohoutek using an infrared tilting-filter photometer. Preliminary analysis of the data established an upper limit to the Comet's fluorescence radiation in methane lines at 3.3 microns

Wind-tunnel investigation of the aerodynamic pressures on the Apollo command module configuration

Wind tunnel study of aerodynamic pressures on Apollo command module configuratio

Modeling the formation of attentive publics in social media: the case of Donald Trump

Previous research has shown the importance of Donald Trump’s Twitter activity, and that of his Twitter following, in spreading his message during the primary and general election campaigns of 2015–2016. However, we know little about how the publics who followed Trump and amplified his messages took shape. We take this case as an opportunity to theorize and test questions about the assembly of what we call “attentive publics” in social media. We situate our study in the context of current discussions of audience formation, attention flow, and hybridity in the United States’ political media system. From this we derive propositions concerning how attentive publics aggregate around a particular object, in this case Trump himself, which we test using time series modeling. We also present an exploration of the possible role of automated accounts in these processes. Our results reiterate the media hybridity described by others, while emphasizing the importance of news media coverage in building social media attentive publics.Accepted manuscrip