Research progress on rheumatoid arthritis-associated depression

Depression is an independent mood disorder and one of the most common comorbidities of rheumatoid arthritis (RA). Growing evidence suggests that there is two-way regulation between RA and depression, resulting in a vicious cycle of RA, depression, poor outcomes, and disease burden. The rising prevalence of RA-associated depression warrants a re-examination of the relationships between them. Here we provide an overview of the etiology and pathological mechanisms of RA-associated depression, and recent advances in treatment with biologics, which will facilitate the development of new and effective prevention and treatment strategies

A 26-32GHz 6-bit Bidirectional Passive Phase Shifter with 14dBm IP1dB and 2.6° RMS Phase Error for Phased Array System in 40nm CMOS

This paper presents a 26-32GHz 6-bit bidirectional passive vector modulation phase shifter in 40nm CMOS for phased array systems. The passive phase shifter consists of a capacitor-free Lange-coupler based IQ generator and a differemtial power combiner. The symmetric design allows bidirectional signal propagation for flexible system configuration. Sizes of the passive switches are optimized to achieve the optimum trade-off between bandwidth and linearity. The overall phase shifter covers a range of 360° with 5.625° resolution and the RMS phase error is between 1.8° and 2.6°. It exhibits less than 0.22dB magnitude imbalance and &lt;2.5° phase imbalance between forward and inverse propagation mode.</p

Identification of hsa-miR-335 as a prognostic signature in gastric cancer.

BACKGROUND: Gastric cancer (GC) is one of the most common malignancy and primary cause of death in Chinese cancer patients. Recurrence is a major factor leading to treatment failure and low level of 5-year survival rate in GC patients following surgical resection. Therefore, identification of biomarkers with potential in predicting recurrence risk is the key problem of the prognosis in GC patients. PATIENTS AND METHODS: A total of 74 GC patients were selected for systematic analysis, consisting of 31 patients with recurrence and 43 patients without recurrence. Firstly, miRNAs microarray and bioinformatics methods were used to characterize differential expressed miRNAs from primary tumor samples. Following, we used a ROC method to select signature with best sensitivity and specificity. Finally, we validated the signature in GC samples (frozen fresh and blood samples) using quantitative PCR. RESULTS: We have identified 12 differential miRNAs including 7 up-regulated and 5 down-regulated miRNAs in recurrence group. Using ROC method, we further ascertained hsa-miR-335 as a signature to recognize recurrence and non-recurrence cases in the training samples. Moreover, we validated this signature using quantitative PCR method in 64 test samples with consistent result with training set. A high frequency recurrence and poor survival were observed in GC cases with high level of hsa-miR-335 (P<0.001). In addition, we evaluated that hsa-miR-335 were involved in regulating target genes in several oncogenic signal-pathways, such as p53, MAPK, TGF-β, Wnt, ERbB, mTOR, Toll-like receptor and focal adhesion. CONCLUSION: Our results indicate that the hsa-miR-335 has the potential to recognize the recurrence risk and relate to the prognosis of GC patients

A 26-30GHz Digitally-Controlled Variable Gain Power Amplifier with Phase Compensation and Third Order Nonlinearity Cancellation Technique

Phased array transceivers at Ka-band frequencies are of greater importance with the rapid development of satellite communications. This paper presents a two-stage variable gain power amplifier (VGPA) with high linearity and low phase variation in 40nm CMOS process. Accurate gain control is realized through digitally controlled current steering. The inter-stage compensation inductor suppresses phase variations among different gain states. Bias of each stage is chosen such that the third order distortions generated by each stage are of opposite polarities, which greatly improves the overall linearity of the cascading amplifier. Without additional trimming, the 26-30GHz VGPA achieves a total 3.5dB gain tuning range with 0.5dB resolution. The measured OP1dB is 14.4dBm and the RMS phase error is 0.29° at 28GHz

A 26-32GHz Differential Attenuator with 0.23dB RMS Attenuation Error and 11.2dBm IP1dB in 40nm CMOS Process

This paper presents a 26-32GHz 6-bit differential attenuator in 40nm CMOS process. This attenuator adopts an optimized cascade scheme that incorporates simplified T-type (ST-type), T-type and Π-type attenuator units. Driven by a complete analysis of the pole-zero pattern introduced by the compensation capacitor, the design achieves a state-of-art uncalibrated RMS attenuation and phase error. The design methodology of shunt branches for constant phase and cascade linearity enhancement achieves a high linearity while minimizing the phase variation across the whole frequency band. The attenuator achieves a 31.5dB attenuation range with 0.5dB step and -8.5 to -9.5dB insertion loss in a compact area of 0.54mm×0.23mm. The measured RMS attenuation error remains below 0.23dB without calibration and phase error is less than 5.58◦. IP1dB in the reference state is better than 11.2dBm across 26–32GHz

Study of an Organic Binder of Cold-Bonded Briquettes with Two Different Iron Bearing Materials

The aim of this study was to investigate the properties of an organic binder used in cold-bonded briquettes (CBBs) prepared from two different iron bearing materials. The applied binder is a type of starch as indicated by chemical analysis, iodine-starch staining and Fourier transform infrared analyses. Thermogravimetric differential scanning calorimetry showed that the binder pyrolysis undergoes four stages: moisture desorption, ash volatilization, pyrolysis of organic matter and decomposition of materials with high activation energy. The difference between the dry and heat-treated samples during the macroscopic failure process is the instability propagation of the crack. The CBB shows a low decrepitation index at 700 °C. The returned fines of CBBs used with the organic binder were applied in two blast furnaces. The industrial trials showed that the CBBs do not influence the performance of the blast furnace and can reduce the fuel consumption rate. The curing rate of the binder decreases, and the growth rate of compressive strength decreases during the curing process. Iron ore particles are bonded together and exist in the form of aggregation after mixing with water and binder. The edges and corners of the particles become blurred, and the original surfaces of the particles are covered with binder film, the surface of which is covered with fine particles. The multi-branched structure of amylopectin provides omnibearing adhesion sites, thus forming binder agglomeration and film leading to a strong adhesion between binder and iron ore particles. Binder film and binder agglomeration work together to make the CBB perform well

A 26-32GHz Differential Attenuator with 0.23dB RMS Attenuation Error and 11.2dBm IP1dB in 40nm CMOS Process

This paper presents a 26-32GHz 6-bit differential attenuator in 40nm CMOS process. This attenuator adopts an optimized cascade scheme that incorporates simplified T-type (ST-type), T-type and Π-type attenuator units. Driven by a complete analysis of the pole-zero pattern introduced by the compensation capacitor, the design achieves a state-of-art uncalibrated RMS attenuation and phase error. The design methodology of shunt branches for constant phase and cascade linearity enhancement achieves a high linearity while minimizing the phase variation across the whole frequency band. The attenuator achieves a 31.5dB attenuation range with 0.5dB step and -8.5 to -9.5dB insertion loss in a compact area of 0.54mm×0.23mm. The measured RMS attenuation error remains below 0.23dB without calibration and phase error is less than 5.58◦. IP1dB in the reference state is better than 11.2dBm across 26–32GHz

MOESM2 of Correlation between insulin-induced estrogen receptor methylation and atherosclerosis

Additional file 2: Figure S1. The mean body weight and blood glucose of the ApoE/Lepr double knockout mice every week