An historical survey of the institutional growth of savings banks

Thesis (M.A.)--Boston Universit

The Hero’s Journey as a Novel, Narrative, and Improvisational Group Intervention on Quality of Life for People with Parkinson’s Disease

Parkinson’s disease (PD) is one of the fastest-growing neurological diseases in the world. Pharmaceutical and surgical interventions continue to advance to better address motor symptoms. However, disability from non-motor symptoms, such as depression, anxiety, and stress persist. Expressive therapies, including art, music, and dance are being explored and implemented more frequently to address this growing need. We developed this study to examine the feasibility of a novel program using online narrative therapy, with constructs from Joseph Campbell’s Hero’s Journey, and improvisation for people with PD (PWPD). Participants from across the U.S. and U.K. met online via Zoom once a week for one hour over the course of 27 consecutive sessions. A PhD student with a professional background in filmmaking and improvisation developed the sessions and led the program. The primary aim was to assess feasibility, the threshold for which was set at 70% of participants attending a minimum of 75% of the classes. Sixteen of 21 participants (76%) completed the study, with all 16 attending at least 85% of the classes. All participants who completed the study stated they enjoyed the class and would like to continue in the program and see it offered to others with PD. The secondary aim was to explore the participants’ experience within the program using a phenomenological approach. Four major themes emerged: 1) There was a high level of interest in the intervention itself as it was deemed unique; 2) Participants struggled to see their own heroic qualities; 3) They reported high levels of connection within the group and 4) The emphasis on having PD faded, replaced by journeys of self-discovery beyond having PD

Borrowed alleles and convergence in serpentine adaptation

ACKNOWLEDGMENTS. We thank members of the L.Y. and K.B. laboratories for helpful discussions. This work was supported through the European Research Council Grant StG CA629F04E (to L.Y.); a Harvard University Milton Fund Award (to K.B.); Ruth L. Kirschstein National Research Service Award 1 F32 GM096699 from the NIH (to L.Y.); National Science Foundation Grant IOS-1146465 (to K.B.); NIH National Institute of General Medical Sciences Grant 2R01GM078536 (to D.E.S.); and Biotechnology and Biological Sciences Research Council Grant BB/L000113/1 (to D.E.S.)Peer reviewedPublisher PD

The Vac14p–Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover

Phosphoinositide-signaling lipids function in diverse cellular pathways. Dynamic changes in the levels of these signaling lipids regulate multiple processes. In particular, when Saccharomyces cerevisiae cells are exposed to hyperosmotic shock, PI3,5P2 (phosphatidylinositol [PI] 3,5-bisphosphate) levels transiently increase 20-fold. This causes the vacuole to undergo multiple acute changes. Control of PI3,5P2 levels occurs through regulation of both its synthesis and turnover. Synthesis is catalyzed by the PI3P 5-kinase Fab1p, and turnover is catalyzed by the PI3,5P2 5-phosphatase Fig4p. In this study, we show that two putative Fab1p activators, Vac7p and Vac14p, independently regulate Fab1p activity. Although Vac7p only regulates Fab1p, surprisingly, we find that Vac14 regulates both Fab1p and Fig4p. Moreover, Fig4p itself functions in both PI3,5P2 synthesis and turnover. In both the absence and presence of Vac7p, the Vac14p–Fig4p complex controls the hyperosmotic shock–induced increase in PI3,5P2 levels. These findings suggest that the dynamic changes in PI3,5P2 are controlled through a tight coupling of synthesis and turnover