11 research outputs found
Image2_Cuproptosis-Related genes in the prognosis of colorectal cancer and their correlation with the tumor microenvironment.JPEG
Colorectal cancer (CRC) is a common tumor disease of the digestive system with high incidence and mortality. Cuproptosis has recently been found to be a new form of cell death. The clinical significance of cuproptosis-related genes (CRGs) in CRC is not clear. In this study, The Cancer Genome Atlas Colon and Rectal Cancer dataset was used to analyze the relationship between CRGs and clinical characteristics of CRC by differential expression analysis and Kaplan–Meier survival (K-M) analysis. Based on CRGs, prognosis model and risk score of CRC was constructed in COADREAD by multivariate Cox analysis. Receiver operating curves (ROC) analysis, K-M analysis and calibration analysis in GDC TCGA Colon Cancer dataset were applied to validating model. Subsequently, the relationship between risk score of CRC and immune microenvironment was analyzed by multiple immune score algorithms. Finally, we found that most CRGs were differentially expressed between tumors and normal tissues. Some CRGs were differentially expressed among different clinical characteristics. K-M analysis showed that the CRGs were related to overall survival (OS), disease-specific survival, and progression-free survival. Subsequently, DLAT and CDKN2A were identified as risk factors for OS in CRC by multivariate Cox analysis, and the risk score was established. K–M analysis showed that there was a significant difference in OS between the high-risk and low-risk groups, which were grouped by risk score median. ROC analysis showed that the risk score performs well in predicting the 1-year, 3-year and 5-year OS. Enrichment analysis showed that the differentially expressed genes between the high- and low-risk groups were enriched in immune-related signaling pathways. Further analysis showed that there were significant differences in the levels of immune cells and stromal cells between the high- and low-risk groups. The high-risk group had higher levels of immune cells and interstitial cells. At the same time, the high-risk group had a higher immune escape ability, and the predicted immune treatment response in the high-risk group was poor. In conclusion, CRGs can be used as prognostic factors in CRC and are closely related to the levels of immune cells and stromal cells in the tumor microenvironment.</p
Image1_Cuproptosis-Related genes in the prognosis of colorectal cancer and their correlation with the tumor microenvironment.JPEG
Colorectal cancer (CRC) is a common tumor disease of the digestive system with high incidence and mortality. Cuproptosis has recently been found to be a new form of cell death. The clinical significance of cuproptosis-related genes (CRGs) in CRC is not clear. In this study, The Cancer Genome Atlas Colon and Rectal Cancer dataset was used to analyze the relationship between CRGs and clinical characteristics of CRC by differential expression analysis and Kaplan–Meier survival (K-M) analysis. Based on CRGs, prognosis model and risk score of CRC was constructed in COADREAD by multivariate Cox analysis. Receiver operating curves (ROC) analysis, K-M analysis and calibration analysis in GDC TCGA Colon Cancer dataset were applied to validating model. Subsequently, the relationship between risk score of CRC and immune microenvironment was analyzed by multiple immune score algorithms. Finally, we found that most CRGs were differentially expressed between tumors and normal tissues. Some CRGs were differentially expressed among different clinical characteristics. K-M analysis showed that the CRGs were related to overall survival (OS), disease-specific survival, and progression-free survival. Subsequently, DLAT and CDKN2A were identified as risk factors for OS in CRC by multivariate Cox analysis, and the risk score was established. K–M analysis showed that there was a significant difference in OS between the high-risk and low-risk groups, which were grouped by risk score median. ROC analysis showed that the risk score performs well in predicting the 1-year, 3-year and 5-year OS. Enrichment analysis showed that the differentially expressed genes between the high- and low-risk groups were enriched in immune-related signaling pathways. Further analysis showed that there were significant differences in the levels of immune cells and stromal cells between the high- and low-risk groups. The high-risk group had higher levels of immune cells and interstitial cells. At the same time, the high-risk group had a higher immune escape ability, and the predicted immune treatment response in the high-risk group was poor. In conclusion, CRGs can be used as prognostic factors in CRC and are closely related to the levels of immune cells and stromal cells in the tumor microenvironment.</p
Table1_Cuproptosis-Related genes in the prognosis of colorectal cancer and their correlation with the tumor microenvironment.DOC
Colorectal cancer (CRC) is a common tumor disease of the digestive system with high incidence and mortality. Cuproptosis has recently been found to be a new form of cell death. The clinical significance of cuproptosis-related genes (CRGs) in CRC is not clear. In this study, The Cancer Genome Atlas Colon and Rectal Cancer dataset was used to analyze the relationship between CRGs and clinical characteristics of CRC by differential expression analysis and Kaplan–Meier survival (K-M) analysis. Based on CRGs, prognosis model and risk score of CRC was constructed in COADREAD by multivariate Cox analysis. Receiver operating curves (ROC) analysis, K-M analysis and calibration analysis in GDC TCGA Colon Cancer dataset were applied to validating model. Subsequently, the relationship between risk score of CRC and immune microenvironment was analyzed by multiple immune score algorithms. Finally, we found that most CRGs were differentially expressed between tumors and normal tissues. Some CRGs were differentially expressed among different clinical characteristics. K-M analysis showed that the CRGs were related to overall survival (OS), disease-specific survival, and progression-free survival. Subsequently, DLAT and CDKN2A were identified as risk factors for OS in CRC by multivariate Cox analysis, and the risk score was established. K–M analysis showed that there was a significant difference in OS between the high-risk and low-risk groups, which were grouped by risk score median. ROC analysis showed that the risk score performs well in predicting the 1-year, 3-year and 5-year OS. Enrichment analysis showed that the differentially expressed genes between the high- and low-risk groups were enriched in immune-related signaling pathways. Further analysis showed that there were significant differences in the levels of immune cells and stromal cells between the high- and low-risk groups. The high-risk group had higher levels of immune cells and interstitial cells. At the same time, the high-risk group had a higher immune escape ability, and the predicted immune treatment response in the high-risk group was poor. In conclusion, CRGs can be used as prognostic factors in CRC and are closely related to the levels of immune cells and stromal cells in the tumor microenvironment.</p
Photoinduced Reactions of Surface-Bound Species on Titania Nanotubes and Platinized Titania Nanotubes: An in Situ FTIR Study
Photoinduced
conversion of surface-bound species on titania nanotubes
that were first oxidized and then reduced (Ti–NT–O<sub>2</sub>–H<sub>2</sub>) and on platinized titania nanotubes
subjected to oxidation and reduction (Pt–Ti–NT–O<sub>2</sub>–H<sub>2</sub>) has been investigated by means of in
situ FTIR spectroscopy. Bidentate and monodentate carbonates as well
as bicarbonates and carboxylates are formed subsequent to exposure
of both Ti–NT–O<sub>2</sub>–H<sub>2</sub> and
Pt–Ti–NT–O<sub>2</sub>–H<sub>2</sub> to
CO<sub>2</sub>. Formic acid was only observed on Pt–Ti–NT–O<sub>2</sub>–H<sub>2</sub>. UV illumination of the nanotubes led
to an increase in the number of surface-bound species as a result
of the further reaction with gas-phase CO<sub>2</sub> with a greater
increase in surface species on Ti–NT–O<sub>2</sub>–H<sub>2</sub> than on Pt–Ti–NT–O<sub>2</sub>–H<sub>2</sub>. The underlying basis of the photoinduced increase in adsorbed
species is discussed for both types of nanotubes. Photoinduced reactions
of surface species also take place and are remarkably different on
the two types of nanotubes. UV illumination of Ti–NT–O<sub>2</sub>–H<sub>2</sub> converts bidentate carbonates and bicarbonates
to monodentate carbonates and carboxylates. There are less, and different,
photoinduced reactions of surface species on Pt–Ti–NT–O<sub>2</sub>–H<sub>2</sub>: bicarbonates and monodentate carbonates
convert to bidentate carbonates on the platinized titania nanotubes,
and there is no obvious reaction involving carboxylates and formic
acid upon irradiation of the platinized nanotubes. These differences
in reactive behavior are discussed in the context of platinum acting
as an efficient trap for photoelectrons which mitigates against reduction
of Ti<sup>4+</sup> to Ti<sup>3+</sup>, stabilizes holes, and alters
the surface photochemistry taking place on the two different types
of nanotubes. Photoinduced holes play an important role in photochemistry
via oxidation of “structural water” and concomitant
production of undercoordinated titania sites
Comparison of Acid Generation in EUV Lithography Films of Poly(4-hydroxystyrene) (PHS) and Noria Adamantyl Ester (Noria-AD<sub>50</sub>)
The mechanism for acid production in phenolic extreme
ultraviolet
(EUV) lithography films containing triphenylsulfonium triflate (Ph<sub>3</sub>S<sup>+</sup>TfO<sup>–</sup>) acid generator has been
investigated by electron paramagnetic resonance (EPR) spectroscopy
and by use of the acid indicator coumarin 6 (C6). Gamma radiolysis
was substituted for the EUV radiation with the assumption that the
chemistry generated by ionization of the matrix does not depend on
the ionization source. PolyÂ(4-hydroxystyrene) (PHS) was first investigated
as a well-studied standard, after which the water-wheel-like cyclic
oligomer derivative containing pendant adamantyl ester groups, noria-AD<sub>50</sub>, was investigated. EPR measurements confirm that the dominant
free radical product is a phenoxyl derivative (PHS-O<sup>•</sup> or noria-O<sup>•</sup>) that exhibits quite slow stretched
exponential recombination kinetics at room temperature. Also observed
at 77 K was the presence of a significant hydrogen atom product of
radiolysis. The <i>G</i> value or yield of acid production
in thin lithography films was measured with the C6 indicator on a
fused silica substrate. It was found that a significant amount of
acid is generated via energy transfer from the irradiated fused-silica
substrate to the Ph<sub>3</sub>S<sup>+</sup>TfO<sup>–</sup> in the films. By varying the film thickness on the substrates, the
substrate effect on the acid yield was quantitatively determined.
After subtraction of the contribution from the substrates, the acid
yield <i>G</i> value in the PHS film with 10 wt % Ph<sub>3</sub>S<sup>+</sup>TfO<sup>–</sup> and 5 wt % C6 was determined
to be 2.5 ± 0.3 protons per 100 eV of radiation. The acid yield
of noria-AD<sub>50</sub> films was found to be 3.2 ± 0.3 protons
per 100 eV
In Situ Synthesis of Highly Dispersed and Ultrafine Metal Nanoparticles from Chalcogels
We report a unique reaction type
for facile synthesis of ultrafine
and well-dispersed Pt nanoparticles supported on chalcogel surfaces.
The nanoparticles are obtained by in situ Pt<sup>2+</sup> reduction
of a chalcogel network formed by the metathesis reaction between K<sub>2</sub>PtCl<sub>4</sub> and Na<sub>4</sub>SnS<sub>4</sub>. The rapid
catalytic ability of the chalcogel-supported Pt nanoparticles is demonstrated
in a recyclable manner by using 4-nitrophenol reduction as a probe
reaction
Methanol Oxidation to Formate on ALD-Prepared VO<sub><i>x</i></sub>/θ-Al<sub>2</sub>O<sub>3</sub> Catalysts: A Mechanistic Study
Well-defined
supported VO<sub><i>x</i></sub>/θ-Al<sub>2</sub>O<sub>3</sub> catalysts were prepared by atomic layer deposition
(ALD) with vanadium coverages of 0.48, 1.20, and 3.40 wt %. In-situ
Raman and UV–vis diffuse reflectance spectroscopy confirm that
the monovanadate, VO<sub>4</sub>, is the predominant vanadium species
at low loadings (0.48 and 1.20 wt %), while polyvanadate VO<sub>4</sub> is the predominant vanadium species for the 3.40 wt % VO<sub><i>x</i></sub>/θ-Al<sub>2</sub>O<sub>3</sub> catalyst. In-situ
FTIR spectroscopy of methanol oxidation to formate, in the absence
of gas-phase oxygen, on the 0.48 wt % VO<sub><i>x</i></sub>/θ-Al<sub>2</sub>O<sub>3</sub>, identified two different formates.
A comparison of the frequencies for the formates adsorbed on just
V<sub>2</sub>O<sub>5</sub> and on just θ-Al<sub>2</sub>O<sub>3</sub> demonstrates that one of these formates is located on aluminum
sites of VO<sub><i>x</i></sub>/θ-Al<sub>2</sub>O<sub>3</sub> while the other is located on vanadium sites. The oxidation
state of vanadium for the VO<sub><i>x</i></sub>/θ-Al<sub>2</sub>O<sub>3</sub> catalyst was determined by XPS after different
reaction times. On the basis of the time dependence of the formate
absorptions and the change in the oxidation state of vanadium in VO<sub><i>x</i></sub>/θ-Al<sub>2</sub>O<sub>3</sub>, a mechanism
is proposed for methanol oxidation and we discuss the role of the
alumina support in the mechanism
Les Empoisonnements sous Louis XIV, d'après les documents inédits de l'affaire des poisons, 1679-1682, par le Dr Lucien Nass,...
Contient une table des matièresAvec mode text
Additional file 4: of Relationship between systolic blood pressure and all-cause mortality: a prospective study in a cohort of Chinese adults
Supplementary Table S4. Hazard ratios (HR) and 95% confidence intervals (95% CI) of all-cause mortality according to systolic blood pressure groups after exclusion of individuals who were older than 70 years. (DOC 52 kb
DataSheet_1_Excessive weight gain onset-age and risk of developing diabetes mellitus: a large, prospective Chinese cohort study.docx
BackgroundExcessive weight gain and obesity are widely accepted as risk factors for diabetes mellitus, and the age at which obesity onsets may be related to the development of cardiovascular diseases and certain cancers. Here, we aimed to investigate associations between the onset-age of overweight/obesity and risk of developing diabetes mellitus in China.Methods42,144 people with the normal weight range and without diabetes at baseline, were enrolled from the Kailuan cohort which began on the 1st June 2006. All participants were followed-up, biennially, until 31st December 2017. During follow-up, 11,220 participants had become overweight/obese. For each case, one normal-weight control was matched according to age ( ± 1 year) and sex. Our final analysis included 10,858 case-control pairs. An age-scaled Cox model was implemented to estimate hazard ratios (HR) with corresponding 95% confidence intervals (CI) for diabetes mellitus incidence across age-groups.ResultsAt a median follow-up of 5.46 years, 1,403 cases of diabetes mellitus were identified. After multivariate adjustments, age-scaled Cox modelling suggested that risk gradually attenuated with every 10 year increase in age of onset of overweight/obesity. Diabetes mellitus adjusted HRs (aHRs) for new-onset overweight/obesity at ConclusionParticipants with early onset of excessive weight gain issues are at considerably higher risk of developing diabetes mellitus compared to those who maintain a normal weight.</p