Dark Matter Constraints from the Sagittarius Dwarf and Tail System

2MASS has provided a three-dimensional map of the >360 degree, wrapped tidal tails of the Sagittarius (Sgr) dwarf spheroidal galaxy, as traced by M giant stars. With the inclusion of radial velocity data for stars along these tails, strong constraints exist for dynamical models of the Milky Way-Sgr interaction. N-body simulations of Sgr disruption with model parameters spanning a range of initial conditions (e.g., Sgr mass and orbit, Galactic rotation curve, halo flattening) are used to find parameterizations that match almost every extant observational constraint of the Sgr system. We discuss the implications of the Sgr data and models for the orbit, mass and M/L of the Sgr bound core as well as the strength, flattening, and lumpiness of the Milky Way potential.Comment: 6 pages, 0 figures. Contribution to proceedings of ``IAU Symposium 220: Dark Matter in Galaxies'', eds. S. Ryder, D.J. Pisano, M. Walker, and K. Freema

Multimodal Imaging of Photoreceptor Structure in Choroideremia

Purpose Choroideremia is a progressive X-linked recessive dystrophy, characterized by degeneration of the retinal pigment epithelium (RPE), choroid, choriocapillaris, and photoreceptors. We examined photoreceptor structure in a series of subjects with choroideremia with particular attention to areas bordering atrophic lesions. Methods Twelve males with clinically-diagnosed choroideremia and confirmed hemizygous mutations in the CHM gene were examined. High-resolution images of the retina were obtained using spectral domain optical coherence tomography (SD-OCT) and both confocal and non-confocal split-detector adaptive optics scanning light ophthalmoscope (AOSLO) techniques. Results Eleven CHM gene mutations (3 novel) were identified; three subjects had the same mutation and one subject had two mutations. SD-OCT findings included interdigitation zone (IZ) attenuation or loss in 10/12 subjects, often in areas with intact ellipsoid zones; RPE thinning in all subjects; interlaminar bridges in the imaged areas of 10/12 subjects; and outer retinal tubulations (ORTs) in 10/12 subjects. Only split-detector AOSLO could reliably resolve cones near lesion borders, and such cones were abnormally heterogeneous in morphology, diameter and density. On split-detector imaging, the cone mosaic terminated sharply at lesion borders in 5/5 cases examined. Split-detector imaging detected remnant cone inner segments within ORTs, which were generally contiguous with a central patch of preserved retina. Conclusions Early IZ dropout and RPE thinning on SD-OCT are consistent with previously published results. Evidence of remnant cone inner segments within ORTs and the continuity of the ORTs with preserved retina suggests that these may represent an intermediate state of retinal degeneration prior to complete atrophy. Taken together, these results supports a model of choroideremia in which the RPE degenerates before photoreceptors

The Most Massive Black Holes in the Universe: Effects of Mergers in Massive Galaxy Clusters

Recent observations support the idea that nuclear black holes grew by gas accretion while shining as luminous quasars at high redshift, and they establish a relation of the black hole mass with the host galaxy's spheroidal stellar system. We develop an analytic model to calculate the expected impact of mergers on the masses of black holes in massive clusters of galaxies. We use the extended Press-Schechter formalism to generate Monte Carlo merger histories of halos with a mass 10^{15} h^{-1} Msun. We assume that the black hole mass function at z=2 is similar to that inferred from observations at z=0 (since quasar activity declines markedly at z<2), and we assign black holes to the progenitor halos assuming a monotonic relation between halo mass and black hole mass. We follow the dynamical evolution of subhalos within larger halos, allowing for tidal stripping, the loss of orbital energy by dynamical friction, and random orbital perturbations in gravitational encounters with subhalos, and we assume that mergers of subhalos are followed by mergers of their central black holes. Our analytic model reproduces numerical estimates of the subhalo mass function. We find that the most massive black holes in massive clusters typically grow by a factor ~ 2 by mergers after gas accretion has stopped. In our ten realizations of 10^{15} h^{-1} Msun clusters, the highest initial (z=2) black hole masses are 5-7 x 10^9 Msun, but four of the clusters contain black holes in the range 1-1.5 x 10^{10} Msun at z=0. Satellite galaxies may host black holes whose mass is comparable to, or even greater than, that of the central galaxy. Thus, black hole mergers can significantly extend the very high end of the black hole mass function.Comment: 13 pages, 7 figures, accepted for publication in The Astrophysical Journa

Microscopic Inner Retinal Hyper-reflective Phenotypes in Retinal and Neurologic Disease

Purpose. We surveyed inner retinal microscopic features in retinal and neurologic disease using a reflectance confocal adaptive optics scanning light ophthalmoscope (AOSLO). Methods. Inner retinal images from 101 subjects affected by one of 38 retinal or neurologic conditions and 11 subjects with no known eye disease were examined for the presence of hyper-reflective features other than vasculature, retinal nerve fiber layer, and foveal pit reflex. The hyper-reflective features in the AOSLO images were grouped based on size, location, and subjective texture. Clinical imaging, including optical coherence tomography (OCT), scanning laser ophthalmoscopy, and fundus photography was analyzed for comparison. Results. Seven categories of hyper-reflective inner retinal structures were identified, namely punctate reflectivity, nummular (disc-shaped) reflectivity, granular membrane, waxy membrane, vessel-associated membrane, microcysts, and striate reflectivity. Punctate and nummular reflectivity also was found commonly in normal volunteers, but the features in the remaining five categories were found only in subjects with retinal or neurologic disease. Some of the features were found to change substantially between follow up imaging months apart. Conclusions. Confocal reflectance AOSLO imaging revealed a diverse spectrum of normal and pathologic hyper-reflective inner and epiretinal features, some of which were previously unreported. Notably, these features were not disease-specific, suggesting that they might correspond to common mechanisms of degeneration or repair in pathologic states. Although prospective studies with larger and better characterized populations, along with imaging of more extensive retinal areas are needed, the hyper-reflective structures reported here could be used as disease biomarkers, provided their specificity is studied further

Hierarchical galaxy formation and substructure in the Galaxy's stellar halo

We develop an explicit model for the formation of the stellar halo from tidally disrupted, accreted dwarf satellites in the cold dark matter (CDM) framework, focusing on predictions testable with the Sloan Digital Sky Survey (SDSS) and other wide-field surveys. Subhalo accretion and orbital evolution are calculated using a semi-analytic approach within the Press-Schechter formalism. Motivated by our previous work, we assume that low-mass subhalos (v < 30 km/s) can form significant populations of stars only if they accreted a substantial fraction of their mass before the epoch of reionization. With this assumption, the model reproduces the observed velocity function of galactic satellites in the Local Group, solving the ``dwarf satellite problem'' without modifying the popular LCDM cosmology. The disrupted satellites yield a stellar distribution with a total mass and radial density profile consistent with those observed for the Milky Way stellar halo. Most significantly, the model predicts the presence of many large-scale, coherent substructures in the outer halo. These substructures are remnants of individual, tidally disrupted dwarf satellite galaxies. Substructure is more pronounced at large galactocentric radii because of the smaller number density of tidal streams and the longer orbital times. This model provides a natural explanation for the coherent structures in the outer stellar halo found in the SDSS commissioning data, and it predicts that many more such structures should be found as the survey covers more of the sky. The detection (or non-detection) and characterization of such structures could eventually test variants of the CDM scenario, especially those that aim to solve the dwarf satellite problem by enhancing satellite disruption.Comment: 12 pages, 8 figures, Submitted to Ap

Neutral Meson Photoproduction in SUf(3)SU_f(3) χ\chiPT

We present the results for the electric dipole amplitude for $\gamma N \to \pi^0 N$ at threshold at the $O(p^2)$ level in SU$_f$(3) chiral perturbation theory. We find that the SU$_f$(3) results differ only slightly from the SU$_f$(2) results. At the $O(p^3)$ level one encounters new, unknown counterterms to fix which one is likely to need the threshold photoproduction data themselves, thus losing predictive power. We suggest, instead, that the {\it difference} between the proton and neutron $\pi^0$ photoproduction amplitudes may provide a test of the convergence properties of the $\chi$PT in the present context. We urge that the neutron's electric dipole amplitude be measured.Comment: Revised version with corrected value of the Kaon loop contributio

Assessing Photoreceptor Structure Associated with Ellipsoid Zone Disruptions Visualized with Optical Coherence Tomography

Purpose: To compare images of photoreceptor layer disruptions obtained with optical coherence tomography (OCT) and adaptive optics scanning light ophthalmoscopy (AOSLO) in a variety of pathologic states.Methods: Five subjects with photoreceptor ellipsoid zone disruption as per OCT and clinical diagnoses of closed-globe blunt ocular trauma (n = 2), macular telangiectasia type 2 (n = 1), blue-cone monochromacy (n = 1), or cone-rod dystrophy (n = 1) were included. Images were acquired within and around photoreceptor lesions using spectral domain OCT, confocal AOSLO, and split-detector AOSLO.Results: There were substantial differences in the extent and appearance of the photoreceptor mosaic as revealed by confocal AOSLO, split-detector AOSLO, and spectral domain OCT en face view of the ellipsoid zone.Conclusion: Clinically available spectral domain OCT, viewed en face or as B-scan, may lead to misinterpretation of photoreceptor anatomy in a variety of diseases and injuries. This was demonstrated using split-detector AOSLO to reveal substantial populations of photoreceptors in areas of no, low, or ambiguous ellipsoid zone reflectivity with en face OCT and confocal AOSLO. Although it is unclear if these photoreceptors are functional, their presence offers hope for therapeutic strategies aimed at preserving or restoring photoreceptor function

Non-equilibrium phase transitions in biomolecular signal transduction

We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of any molecule, by means of which the switch is implemented, are highly stochastic. The emergence of switching is a nonequilibrium phase transition in an energetically driven, dissipative system described by a master equation. We use operator and functional integral methods from reaction-diffusion theory to solve for the phase structure, noise spectrum, and escape trajectories and first-passage times of a class of minimal models of switches, showing how all critical properties for switch behavior can be computed within a unified framework

Reionization and the abundance of galactic satellites

One of the main challenges facing standard hierarchical structure formation models is that the predicted abundance of galactic subhalos with circular velocities of 10-30 km/s is an order of magnitude higher than the number of satellites actually observed within the Local Group. Using a simple model for the formation and evolution of dark halos, based on the extended Press-Schechter formalism and tested against N-body results, we show that the theoretical predictions can be reconciled with observations if gas accretion in low-mass halos is suppressed after the epoch of reionization. In this picture, the observed dwarf satellites correspond to the small fraction of halos that accreted substantial amounts of gas before reionization. The photoionization mechanism naturally explains why the discrepancy between predicted halos and observed satellites sets in at about 30 km/s, and for reasonable choices of the reionization redshift (z_re = 5-12) the model can reproduce both the amplitude and shape of the observed velocity function of galactic satellites. If this explanation is correct, then typical bright galaxy halos contain many low-mass dark matter subhalos. These might be detectable through their gravitational lensing effects, through their influence on stellar disks, or as dwarf satellites with very high mass-to-light ratios. This model also predicts a diffuse stellar component produced by large numbers of tidally disrupted dwarfs, perhaps sufficient to account for most of the Milky Way's stellar halo.Comment: 5 pages, 2 figures, Submitted to Ap

Testing Cosmological Models Against the Abundance of Damped Lyman-Alpha Absorbers

We calculate the number of damped Lyman-alpha absorbers expected in various popular cosmological models as a function of redshift and compare our predictions with observed abundances. The Press-Schechter formalism is used to obtain the distribution of halos with circular velocity in different cosmologies, and we calibrate the relation between circular velocity and absorption cross-section using detailed gas dynamical simulations of a ``standard'' cold dark matter (CDM) model. Because of this calibration, our approach makes more realistic assumptions about the absorption properties of collapsed objects than previous, analytic calculations of the damped Lyman-alpha abundance. CDM models with Omega_0=1, H_0=50, baryon density Omega_b=0.05, and scale-invariant primeval fluctuations reproduce the observed incidence and redshift evolution of damped Lyman-alpha absorption to within observational uncertainty, for both COBE normalization (sigma_8=1.2) and a lower normalization (sigma_8=0.7) that better matches the observed cluster abundance at z=0. A tilted (n=0.8, sigma_8=0.7) CDM model tends to underproduce absorption, especially at z=4. With COBE normalization, a CDM model with Omega_0=0.4, Omega_{Lambda}=0.6 gives an acceptable fit to the observed absorption; an open CDM model is marginally acceptable if Omega_0 is at least 0.4 and strongly inconsistent with the z=4 data if Omega_0=0.3. Mixed dark matter models tend not to produce sufficient absorption, being roughly comparable to tilted CDM models if Omega_{nu} = 0.2 and failing drastically if Omega_{nu} = 0.3.Comment: AASlatex, 13 pages w/ 2 embedded ps figures. To be published in ApJ, Sept. 1, 199