1 research outputs found
Targeting Tumor Cells by Natural Anti-Carbohydrate Antibodies Using Rhamnose-Functionalized Liposomes
Recruitment of antibodies in human
immune systems for targeted destruction of tumor cells has emerged
as an exciting area of research due to its low occurrence of side
effects, high efficacy, and high specificity. The presence of large
amounts of anticarbohydrate natural antibodies in human sera has prompted
research efforts to utilize carbohydrate epitopes for immune recruitment.
Here, we have developed a general strategy for specific targeted destruction
of tumor cells based on rhamnose-functionalized liposomes. Tumor cells
artificially decorated with rhamnose epitopes were subjected to complement-mediated
cytotoxicity <i>in vitro</i> and showed delayed tumor growth <i>in vivo</i>. This study highlights the therapeutic potential
for activation of endogenous immune response through cell-surface
glycan engineering