11 research outputs found
DataSheet2_Prognostic value of long non-coding RNA MALAT1 in hepatocellular carcinoma: A study based on multi-omics analysis and RT-PCR validation.CSV
Background: This study aimed to explore the relationship between MALAT1 and the prognosis of patients with hepatocellular carcinoma (HCC).Methods: We constructed a MALAT1 protein-protein interaction network using the STRING database and a network of competing endogenous RNAs (ceRNAs) using the StarBase database. Using data from the GEPIA2 database, we studied the association between genes in these networks and survival of patients with HCC. The potential mechanisms underlying the relationship between MALAT1 and HCC prognosis were studied using combined data from RNA sequencing, DNA methylation, and somatic mutation data from The Cancer Genome Atlas (TCGA) liver cancer cohort. Tumor tissues and 19 paired adjacent non-tumor tissues (PANTs) from HCC patients who underwent radical resection were analyzed for MALAT1 mRNA levels using real-time PCR, and associations of MALAT1 expression with clinicopathological features or prognosis of patients were analyzed using log-rank test and Gehan-Breslow-Wilcoxon test.Results: Five interacting proteins and five target genes of MALAT1 in the ceRNA network significantly correlated with poor survival of patients with HCC (p Conclusion:MALAT1 is overexpressed in HCC, and higher expression is associated with worse prognosis. MALAT1 mRNA level may serve as a prognostic marker for patients with HCC after hepatectomy.</p
Image3_Prognostic value of long non-coding RNA MALAT1 in hepatocellular carcinoma: A study based on multi-omics analysis and RT-PCR validation.JPEG
Background: This study aimed to explore the relationship between MALAT1 and the prognosis of patients with hepatocellular carcinoma (HCC).Methods: We constructed a MALAT1 protein-protein interaction network using the STRING database and a network of competing endogenous RNAs (ceRNAs) using the StarBase database. Using data from the GEPIA2 database, we studied the association between genes in these networks and survival of patients with HCC. The potential mechanisms underlying the relationship between MALAT1 and HCC prognosis were studied using combined data from RNA sequencing, DNA methylation, and somatic mutation data from The Cancer Genome Atlas (TCGA) liver cancer cohort. Tumor tissues and 19 paired adjacent non-tumor tissues (PANTs) from HCC patients who underwent radical resection were analyzed for MALAT1 mRNA levels using real-time PCR, and associations of MALAT1 expression with clinicopathological features or prognosis of patients were analyzed using log-rank test and Gehan-Breslow-Wilcoxon test.Results: Five interacting proteins and five target genes of MALAT1 in the ceRNA network significantly correlated with poor survival of patients with HCC (p Conclusion:MALAT1 is overexpressed in HCC, and higher expression is associated with worse prognosis. MALAT1 mRNA level may serve as a prognostic marker for patients with HCC after hepatectomy.</p
Image5_Prognostic value of long non-coding RNA MALAT1 in hepatocellular carcinoma: A study based on multi-omics analysis and RT-PCR validation.JPEG
Background: This study aimed to explore the relationship between MALAT1 and the prognosis of patients with hepatocellular carcinoma (HCC).Methods: We constructed a MALAT1 protein-protein interaction network using the STRING database and a network of competing endogenous RNAs (ceRNAs) using the StarBase database. Using data from the GEPIA2 database, we studied the association between genes in these networks and survival of patients with HCC. The potential mechanisms underlying the relationship between MALAT1 and HCC prognosis were studied using combined data from RNA sequencing, DNA methylation, and somatic mutation data from The Cancer Genome Atlas (TCGA) liver cancer cohort. Tumor tissues and 19 paired adjacent non-tumor tissues (PANTs) from HCC patients who underwent radical resection were analyzed for MALAT1 mRNA levels using real-time PCR, and associations of MALAT1 expression with clinicopathological features or prognosis of patients were analyzed using log-rank test and Gehan-Breslow-Wilcoxon test.Results: Five interacting proteins and five target genes of MALAT1 in the ceRNA network significantly correlated with poor survival of patients with HCC (p Conclusion:MALAT1 is overexpressed in HCC, and higher expression is associated with worse prognosis. MALAT1 mRNA level may serve as a prognostic marker for patients with HCC after hepatectomy.</p
Image4_Prognostic value of long non-coding RNA MALAT1 in hepatocellular carcinoma: A study based on multi-omics analysis and RT-PCR validation.JPEG
Background: This study aimed to explore the relationship between MALAT1 and the prognosis of patients with hepatocellular carcinoma (HCC).Methods: We constructed a MALAT1 protein-protein interaction network using the STRING database and a network of competing endogenous RNAs (ceRNAs) using the StarBase database. Using data from the GEPIA2 database, we studied the association between genes in these networks and survival of patients with HCC. The potential mechanisms underlying the relationship between MALAT1 and HCC prognosis were studied using combined data from RNA sequencing, DNA methylation, and somatic mutation data from The Cancer Genome Atlas (TCGA) liver cancer cohort. Tumor tissues and 19 paired adjacent non-tumor tissues (PANTs) from HCC patients who underwent radical resection were analyzed for MALAT1 mRNA levels using real-time PCR, and associations of MALAT1 expression with clinicopathological features or prognosis of patients were analyzed using log-rank test and Gehan-Breslow-Wilcoxon test.Results: Five interacting proteins and five target genes of MALAT1 in the ceRNA network significantly correlated with poor survival of patients with HCC (p Conclusion:MALAT1 is overexpressed in HCC, and higher expression is associated with worse prognosis. MALAT1 mRNA level may serve as a prognostic marker for patients with HCC after hepatectomy.</p
Image2_Prognostic value of long non-coding RNA MALAT1 in hepatocellular carcinoma: A study based on multi-omics analysis and RT-PCR validation.JPEG
Background: This study aimed to explore the relationship between MALAT1 and the prognosis of patients with hepatocellular carcinoma (HCC).Methods: We constructed a MALAT1 protein-protein interaction network using the STRING database and a network of competing endogenous RNAs (ceRNAs) using the StarBase database. Using data from the GEPIA2 database, we studied the association between genes in these networks and survival of patients with HCC. The potential mechanisms underlying the relationship between MALAT1 and HCC prognosis were studied using combined data from RNA sequencing, DNA methylation, and somatic mutation data from The Cancer Genome Atlas (TCGA) liver cancer cohort. Tumor tissues and 19 paired adjacent non-tumor tissues (PANTs) from HCC patients who underwent radical resection were analyzed for MALAT1 mRNA levels using real-time PCR, and associations of MALAT1 expression with clinicopathological features or prognosis of patients were analyzed using log-rank test and Gehan-Breslow-Wilcoxon test.Results: Five interacting proteins and five target genes of MALAT1 in the ceRNA network significantly correlated with poor survival of patients with HCC (p Conclusion:MALAT1 is overexpressed in HCC, and higher expression is associated with worse prognosis. MALAT1 mRNA level may serve as a prognostic marker for patients with HCC after hepatectomy.</p
Image1_Prognostic value of long non-coding RNA MALAT1 in hepatocellular carcinoma: A study based on multi-omics analysis and RT-PCR validation.JPEG
Background: This study aimed to explore the relationship between MALAT1 and the prognosis of patients with hepatocellular carcinoma (HCC).Methods: We constructed a MALAT1 protein-protein interaction network using the STRING database and a network of competing endogenous RNAs (ceRNAs) using the StarBase database. Using data from the GEPIA2 database, we studied the association between genes in these networks and survival of patients with HCC. The potential mechanisms underlying the relationship between MALAT1 and HCC prognosis were studied using combined data from RNA sequencing, DNA methylation, and somatic mutation data from The Cancer Genome Atlas (TCGA) liver cancer cohort. Tumor tissues and 19 paired adjacent non-tumor tissues (PANTs) from HCC patients who underwent radical resection were analyzed for MALAT1 mRNA levels using real-time PCR, and associations of MALAT1 expression with clinicopathological features or prognosis of patients were analyzed using log-rank test and Gehan-Breslow-Wilcoxon test.Results: Five interacting proteins and five target genes of MALAT1 in the ceRNA network significantly correlated with poor survival of patients with HCC (p Conclusion:MALAT1 is overexpressed in HCC, and higher expression is associated with worse prognosis. MALAT1 mRNA level may serve as a prognostic marker for patients with HCC after hepatectomy.</p
DataSheet1_Prognostic value of long non-coding RNA MALAT1 in hepatocellular carcinoma: A study based on multi-omics analysis and RT-PCR validation.CSV
Background: This study aimed to explore the relationship between MALAT1 and the prognosis of patients with hepatocellular carcinoma (HCC).Methods: We constructed a MALAT1 protein-protein interaction network using the STRING database and a network of competing endogenous RNAs (ceRNAs) using the StarBase database. Using data from the GEPIA2 database, we studied the association between genes in these networks and survival of patients with HCC. The potential mechanisms underlying the relationship between MALAT1 and HCC prognosis were studied using combined data from RNA sequencing, DNA methylation, and somatic mutation data from The Cancer Genome Atlas (TCGA) liver cancer cohort. Tumor tissues and 19 paired adjacent non-tumor tissues (PANTs) from HCC patients who underwent radical resection were analyzed for MALAT1 mRNA levels using real-time PCR, and associations of MALAT1 expression with clinicopathological features or prognosis of patients were analyzed using log-rank test and Gehan-Breslow-Wilcoxon test.Results: Five interacting proteins and five target genes of MALAT1 in the ceRNA network significantly correlated with poor survival of patients with HCC (p Conclusion:MALAT1 is overexpressed in HCC, and higher expression is associated with worse prognosis. MALAT1 mRNA level may serve as a prognostic marker for patients with HCC after hepatectomy.</p
Structurally Tailoring Clay Nanosheets to Design Emerging Macrofibers with Tunable Mechanical Properties and Thermal Behavior
Bio-derived nanomaterials are promising candidates for
spinning
high-performance sustainable textiles, but the inherent flammability
of biomass-based fibers seriously limits their applications. There
is still an urgent need to improve fiber flame retardancy while maintaining
excellent mechanical performance. Here, inspired by the structural
properties of layered nanoclay, we report a novel and efficient strategy
to synthesize the strong, super tough, and flame-retardant nanocellulose/clay/sodium
alginate (CRS) macrofibers via wet-spinning and directional drying.
Benefiting from the precise modulation of arrangement and orientation
of nanoclay in macrofibers, the new inorganic structure exhibits excellent
mechanical and thermal functional properties. The anisotropic structure
contributes to high toughness: the tensile strength was 373.3 MPa
and the toughness was 26.92 MJ·m–3. Remarkably,
rectorite nanosheets as a thermal and qualitative insulator significantly
improve the flame retardancy of the CRS fibers with a heat release
rate as low as 6.07 W/g, thermal conductivity of 90.5 mW/(m·K),
and good temperature tolerance (ranging from −196 to 100 °C).
This facile and high-efficiency strategy may have great scalability
in manufacturing high-strength, super tough, and flame-retardant fibers
for emerging biodegradable next-generation artificial fibers
Structurally Tailoring Clay Nanosheets to Design Emerging Macrofibers with Tunable Mechanical Properties and Thermal Behavior
Bio-derived nanomaterials are promising candidates for
spinning
high-performance sustainable textiles, but the inherent flammability
of biomass-based fibers seriously limits their applications. There
is still an urgent need to improve fiber flame retardancy while maintaining
excellent mechanical performance. Here, inspired by the structural
properties of layered nanoclay, we report a novel and efficient strategy
to synthesize the strong, super tough, and flame-retardant nanocellulose/clay/sodium
alginate (CRS) macrofibers via wet-spinning and directional drying.
Benefiting from the precise modulation of arrangement and orientation
of nanoclay in macrofibers, the new inorganic structure exhibits excellent
mechanical and thermal functional properties. The anisotropic structure
contributes to high toughness: the tensile strength was 373.3 MPa
and the toughness was 26.92 MJ·m–3. Remarkably,
rectorite nanosheets as a thermal and qualitative insulator significantly
improve the flame retardancy of the CRS fibers with a heat release
rate as low as 6.07 W/g, thermal conductivity of 90.5 mW/(m·K),
and good temperature tolerance (ranging from −196 to 100 °C).
This facile and high-efficiency strategy may have great scalability
in manufacturing high-strength, super tough, and flame-retardant fibers
for emerging biodegradable next-generation artificial fibers
Structurally Tailoring Clay Nanosheets to Design Emerging Macrofibers with Tunable Mechanical Properties and Thermal Behavior
Bio-derived nanomaterials are promising candidates for
spinning
high-performance sustainable textiles, but the inherent flammability
of biomass-based fibers seriously limits their applications. There
is still an urgent need to improve fiber flame retardancy while maintaining
excellent mechanical performance. Here, inspired by the structural
properties of layered nanoclay, we report a novel and efficient strategy
to synthesize the strong, super tough, and flame-retardant nanocellulose/clay/sodium
alginate (CRS) macrofibers via wet-spinning and directional drying.
Benefiting from the precise modulation of arrangement and orientation
of nanoclay in macrofibers, the new inorganic structure exhibits excellent
mechanical and thermal functional properties. The anisotropic structure
contributes to high toughness: the tensile strength was 373.3 MPa
and the toughness was 26.92 MJ·m–3. Remarkably,
rectorite nanosheets as a thermal and qualitative insulator significantly
improve the flame retardancy of the CRS fibers with a heat release
rate as low as 6.07 W/g, thermal conductivity of 90.5 mW/(m·K),
and good temperature tolerance (ranging from −196 to 100 °C).
This facile and high-efficiency strategy may have great scalability
in manufacturing high-strength, super tough, and flame-retardant fibers
for emerging biodegradable next-generation artificial fibers